Granulosa cell tumour 1169291 216936775 2008-06-03T22:00:37Z 207.194.133.9 /* Histology */ {{DiseaseDisorder infobox | Name = Granulosa cell tumour | ICD10 = {{ICD10|C|56||c|51}} | ICD9 = {{ICD9|183}} | ICDO = 8620 | Image = | Caption = | OMIM = | MedlinePlus = | eMedicineSubj = med | eMedicineTopic = 928 | DiseasesDB = | MeshID = D006106| }} {{Cleanup|date=September 2007}} '''Granulosa cell tumo(u)rs''' (or '''granulosa-theca cell tumo(u)rs''') are [[tumor]]s of the [[granulosa cell]]. They are part of the [[sex cord-stromal tumour]] group of [[Ovarian cancer|ovarian neoplasm]]s. The peak age at which they occur is 50-55 years, but they may occur at any age. ==Clinical presentation== [[Estrogen]]s are produced by ''functioning'' tumours, and the clinical presentation depends on the patient's age. * If the patient is [[postmenopausal]], she usually presents with [[abnormal uterine bleeding]]. * If the patient is of [[reproductive]] age, she would present with [[menometrorrhagia]]. However, in some cases she may stop ovulating altogether. * If the patient has not undergone [[puberty]], [[isosexual-pseudo-precocity]] may be seen. ==Histology== The most characteristic gross appearance is a smooth surfaced solid and cystic lesion with the cysts filled with [[blood]]. Hemoperitoneum is an infrequent but classical presentation. A large variety of [[histology|histological]] presentations exists, but they have two key features: #[[Call-Exner bodies]] ([[granulosa cell]]s arranged haphazardly around a space containing [[eosinophilic]] fluid); ''and'' #Pale uniform nuclei, often with grooves There have been cases where the tumor presented as a single, cyst-like, space, with no internal bleeding. ==External links== * {{GPnotebook|-46858173}} * [http://www-medlib.med.utah.edu/WebPath/FEMHTML/FEM057.html Photo of tumor] * [http://www.bioscience.org/atlases/tumpath/freprod/ovary/9/micro.htm Slides] * [http://www.indiandoctors.com/OBGYN/Malignancy/Malignancy_02.htm indiandoctors.com] {{Tumor histology}} [[Category:Gynecology]] [[Category:Types of cancer]] {{oncology-stub}} [[es:Tumor de células de la granulosa]]