Granulosa cell tumour
1169291
216936775
2008-06-03T22:00:37Z
207.194.133.9
/* Histology */
{{DiseaseDisorder infobox |
Name = Granulosa cell tumour |
ICD10 = {{ICD10|C|56||c|51}} |
ICD9 = {{ICD9|183}} |
ICDO = 8620 |
Image = |
Caption = |
OMIM = |
MedlinePlus = |
eMedicineSubj = med |
eMedicineTopic = 928 |
DiseasesDB = |
MeshID = D006106|
}}
{{Cleanup|date=September 2007}}
'''Granulosa cell tumo(u)rs''' (or '''granulosa-theca cell tumo(u)rs''') are [[tumor]]s of the [[granulosa cell]]. They are part of the [[sex cord-stromal tumour]] group of [[Ovarian cancer|ovarian neoplasm]]s.
The peak age at which they occur is 50-55 years, but they may occur at any age.
==Clinical presentation==
[[Estrogen]]s are produced by ''functioning'' tumours, and the clinical presentation depends on the patient's age.
* If the patient is [[postmenopausal]], she usually presents with [[abnormal uterine bleeding]].
* If the patient is of [[reproductive]] age, she would present with [[menometrorrhagia]]. However, in some cases she may stop ovulating altogether.
* If the patient has not undergone [[puberty]], [[isosexual-pseudo-precocity]] may be seen.
==Histology==
The most characteristic gross appearance is a smooth surfaced solid and cystic lesion with the cysts filled with [[blood]].
Hemoperitoneum is an infrequent but classical presentation.
A large variety of [[histology|histological]] presentations exists, but they have two key features:
#[[Call-Exner bodies]] ([[granulosa cell]]s arranged haphazardly around a space containing [[eosinophilic]] fluid); ''and''
#Pale uniform nuclei, often with grooves
There have been cases where the tumor presented as a single, cyst-like, space, with no internal bleeding.
==External links==
* {{GPnotebook|-46858173}}
* [http://www-medlib.med.utah.edu/WebPath/FEMHTML/FEM057.html Photo of tumor]
* [http://www.bioscience.org/atlases/tumpath/freprod/ovary/9/micro.htm Slides]
* [http://www.indiandoctors.com/OBGYN/Malignancy/Malignancy_02.htm indiandoctors.com]
{{Tumor histology}}
[[Category:Gynecology]]
[[Category:Types of cancer]]
{{oncology-stub}}
[[es:Tumor de células de la granulosa]]