Hepatomegaly 1497232 219214448 2008-06-14T03:21:41Z J.delanoy 2372780 Reverted edits by [[Special:Contributions/72.39.49.228|72.39.49.228]] to last version by 202.133.10.12 (using [[WP:HG|Huggle]]) {{SignSymptom infobox | Name = Hepatomegaly | ICD10 = {{ICD10|R|16|.0|r|16}} | ICD9 = {{ICD9|789.1}} | }} '''Hepatomegaly''' is the condition of having an enlarged [[liver]]. It is a nonspecific [[sign (medicine)| medical sign]] having many causes, which can broadly be broken down into [[infection]], direct toxicity, [[hepatic tumour]]s, or [[metabolic disorder]]. Often, hepatomegaly will present as an [[abdominal mass]]. Depending on the cause, it may sometimes present along with [[jaundice]]. ==Diagnosis== After a thorough [[medical history]] and [[physical examination]], [[blood test]]s should be drawn. An important series of blood tests are the [[liver function test]]s, which give a good impression of the patient's broad metabolic picture. An [[ultrasound]] of the liver can reliably detect a dilated [[biliary duct]] system, which helps distinguish [[parenchyma]]l liver disease from extrahepatic [[bile duct obstruction]]. Ultrasound can also detect the characteristic texture of a [[liver cirrhosis|cirrhotic liver]], and can guide [[fine needle aspiration]] of [[cyst]]s, [[abscess]]es and tumours. [[Computed tomography]] (CT) can help obtain more accurate [[anatomy|anatomical]] information, and is unaffected by the [[obesity]] or the presence of [[bowel gas]]es. ==Common Causes== {{incomplete}} ===Infective=== *[[Glandular fever]] (Infectious mononucleosis) This is caused by the Epstein-Barr virus (EBV). *[[Hepatitis]] (Although not all hepatitis viruses cause hepatomegaly) *[[Liver abscess]](pyogenic abscess and amoebic abscess) *[[Malaria]] *[[Amoeba]] infections *[[Hydatid cyst]] *[[Leptospirosis]] *[[Actinomycosis]] ===Neoplastic=== *[[Hemangioma]]s *[[Hepatocellular carcinoma]] *[[Myeloma]] *[[Leukaemia]] *[[Lymphoma]] ===Cirrhotic=== *Portal *Biliary *Cardiac *[[Haemochromatosis]] ===Metabolic=== *[[Fatty infiltration]] *[[Amyloidosis]] *[[Gaucher's disease]] ===Drugs and Toxins=== *[[alcoholism]] *[[poison|poisoning]] *[[drug use|drugs]] ===Congenital=== *[[Hemolytic anemia]] *Riedel's lobe *[[Polycystic disease]] ===Others=== *[[Hunter syndrome]] *[[Zellweger's syndrome]] *[[Carnitine palmitoyltransferase I deficiency]] *[[Right ventricular Failure]] ==See also== * [[Hepatosplenomegaly]] ==External links== * [http://www.nlm.nih.gov/medlineplus/ency/ National Institute of Health's Medline Plus Medical Encyclopedia]: [http://www.nlm.nih.gov/medlineplus/ency/article/003275.htm Hepatomegaly] * [http://www.merck.com/mrkshared/mmanual/home.jsp Merck Manual]: [http://www.merck.com/mrkshared/mmanual/section4/chapter38/38c.jsp Hepatomegaly] {{Digestive system and abdomen symptoms and signs}} [[Category:Medical signs]] [[Category:Hepatology]] [[de:Hepatomegalie]] [[es:Hepatomegalia]] [[fa:بزرگ‌کبدی]] [[fr:Hépatomégalie]] [[pl:Hepatomegalia]] [[pt:Hepatomegalia]] [[ru:Гепатомегалия]] [[fi:Hepatomegalia]]