Hereditary pancreatitis 5565461 215790204 2008-05-29T18:51:37Z DOI bot 6652755 Citation maintenance. Initiated by [[User:Tarun2k|Tarun2k]]. You can [[WP:DOI|use this bot]] yourself! Please [[User:DOI_bot/bugs|report any bugs]]. {{Refimprove|date=June 2007}} {{Infobox_Disease | Name = {{PAGENAME}} | Image = | Caption = | DiseasesDB = 30026 | ICD10 = | ICD9 = | ICDO = | OMIM = 167800 | MedlinePlus = | eMedicineSubj = | eMedicineTopic = | MeshID = }} '''Hereditary Pancreatitis''' is a genetic disease affecting enzyme production in the pancreas. In the pancreas, a genetic mutation causes the enzyme cationin [[trypsinogen]] to be made in a way which renders it resistant to inactivation through [[autolysis]]. Normally this autolysis mechanism prevents trypsinogen from being activated within the pancreas. However, when the abnormal trypsinogen is activated, it causes a chain reaction where all the trypsinogen in the pancreas is activated, effectively digesting the pancreas from the inside. ==Symptoms and Treatment== Symptoms are generally the same as [[acute pancreatitis]], including severe abdominal pain, vomiting, and diarrhea. There is no treatment for the disease, although complications such as malnutrition can be treated with supplimentary pancreatic enzymes. Most estimates place the number of individuals with hereditary pancreatitis in the United States at 1000.{{Fact|date=June 2007}} ==References== * {{cite journal |author=Whitcomb D |title=Hereditary pancreatitis: new insights into acute and chronic pancreatitis |journal=Gut |volume=45 |issue=3 |pages=317–22 |year=1999 |pmid=10446089 |url=http://gut.bmjjournals.com/cgi/content/full/45/3/317}} {{Gastroenterology}} [[Category:Medical emergencies]] [[Category:Gastroenterology]] [[pt:Pancreatite hereditária]]