Hermann Joseph Muller 240846 222659655 2008-06-30T14:02:45Z Lansey 660275 Added in an "Infobox Scientist" {{Infobox Scientist |box_width = |name = Hermann Joseph Muller |image = Replace this image male.svg <!--(filename only)--> |image_size = |caption = |birth_date = [[December 21]] [[1890]] |birth_place = [[New York City]] |death_date = [[April 5]] [[1967]] |death_place = |residence = |citizenship = |nationality = [[United States|American]] |ethnicity = |fields = |workplaces = |alma_mater = |doctoral_advisor = |academic_advisors = |doctoral_students = |notable_students = |known_for = The genetic effects of [[Radiation]] |author_abbrev_bot = |author_abbrev_zoo = |influences = |influenced = |awards = [[Image:Nobel medal dsc06171.jpg|20px]] [[Nobel Prize in Physiology or Medicine]] [[1946]] |religion = |signature = <!--(filename only)--> |footnotes = }} {{for|other Hermann Müllers|Hermann Müller}} '''Hermann Joseph "H. J." Muller''' ([[December 21]], [[1890]] &ndash; [[April 5]], [[1967]]) was a [[Nobel Prize]]-winning [[United States|American]] [[geneticist]] and educator, best known for his work on the physiological and genetic effects of [[radiation]] (X-ray mutagenesis) as well as his outspoken political beliefs. ==Childhood and education== Muller was born in [[New York City]] and excelled in the public schools. As an adolescent, he attended a [[Unitarian]] church and considered himself a [[pantheist]]; in high school he became an [[atheist]]. At 16 he entered [[Columbia University|Columbia College]]. From his first semester he was interested in biology; he became an early convert of the [[Mendelian inheritance|Mendelian]]-[[chromosome]] theory of heredity &mdash; and the concept of genetic [[mutation]]s and [[natural selection]] as the basis for [[evolution]]. He formed a Biology Club and also became a proponent of [[eugenics]]; the connections between biology and society would be his perennial concern. Muller earned a [[Bachelor of Arts|B.A.]] degree in [[1910]] and <ref>Carlson, ''Genes, Radiation, and Society'', pp 17-37</ref> Muller remained at Columbia (the pre-eminent American zoology program at the time, thanks to [[Edmund Beecher Wilson|E. B. Wilson]] and his students) for graduate school. He became interested in the ''[[Drosophila]]'' genetics work of [[Thomas Hunt Morgan]]'s fly lab after undergraduate bottle washers [[Alfred Sturtevant]] and [[Calvin Bridges]] joined his Biology Club. In 1911-1912, studied metabolism at [[Cornell University]], but remained involved with Columbia. He followed the drosophilists as the first genetic maps emerged from Morgan's experiments, and joined Morgan's group in 1912 (after two years of informal participation).<ref>Carlson, ''Genes, Radiation, and Society'', pp 37-69</ref> In the fly group, Muller's contributions were primarily theoretical: explanations for experimental results and ideas and predictions for new experiments. In the emerging collaborative culture of the drosophilists, however, credit was assigned based on results rather than ideas; Muller felt cheated when he was left out of major publications.<ref>Carlson, ''Genes, Radiation, and Society'', pp 70-90; for more on the culture and norms of the fly lab, see ''Lords of the Fly: ''Drosophila'' Genetics and the Experimental Life'', by Robert E. Kohler (University of Chicago Press, 1994).</ref> ==Early career== In 1914, [[Julian Huxley]] offered Muller a position at the recently founded [[Rice University|William Marsh Rice Institute]]; he hurried to complete his [[Doctor of Philosophy|Ph.D.]] degree and moved to Houston for the beginning of the 1915-1916 academic year (his degree was issued in 1916). At Rice, Muller taught biology and continued ''Drosophila'' lab work. In 1918, he proposed an explanation for the dramatic discontinuous alterations in ''[[Oenothera larmarckiana]]'' that were the basis of [[Hugo de Vries]]'s theory of [[mutationism]]: "balanced lethals" allowed the accumulation of recessive mutations, and rare [[crossing over]] events resulted in the sudden expression of these hidden traits. In other words, de Vries's experiments were explainable by the Mendelian-chromosome theory. Muller's work was increasingly focused on [[mutation rate]] and [[lethal mutation]]s. In 1918, Morgan&mdash;shorthanded because many of his students and assistants were drafted for the U.S. entry into [[World War I]]&mdash;convinced Muller to return to Columbia to teach and to expand his experimental program.<ref>Carlson, ''Genes, Radiation, and Society'', pp 91-108</ref> At Columbia, Muller and his collaborator and longtime friend [[Edgar Altenburg]] continued the investigation of lethal mutations. The primary method for detecting such mutations was to measure the sex ratios of the offspring of female flies. They predicted the ratio would vary from 1:1 due to recessive mutations on the X chromosome, which would only be expressed in males (who lacked the functional allele on a second X chromosome). Muller found a strong temperature dependence in mutation rate, leading him to believe that spontaneous mutation was the dominant mode (and to initially discount the role of external factors such as ionizing radiation or chemical agents). In 1920, Muller and Altenburg coauthored a seminal paper in ''[[Genetics (journal)|Genetics]]'' on "modifier genes" that determine the size of mutant ''Drosophila'' wings. In 1919, Muller made the important discovery of a mutant (later found to be a [[chromosomal inversion]]) that appeared to suppress crossing-over, which opened up new avenues in mutation rate studies. However, his appointment at Columbia was not continued; he accepted an offer from the [[University of Texas at Austin|University of Texas]] and left Columbia after the summer of 1920.<ref>Carlson, ''Genes, Radiation, and Society'', pp 109-119</ref> Muller taught at [[University of Texas at Austin|The University of Texas]] from 1920 until 1932. Soon after returning to Texas, he married mathematics professor Jesse Marie Jacobs, whom he had courted previously. In his early years at Texas, Muller's ''Drosophila'' work was slow going; the data from his mutation rate studies were difficult to interpret. In 1923, he began using [[radium]] and [[X-rays]], but the relationship between radiation and mutation was difficult to measure because such radiation also sterilized the flies. In this period, he became more involved with eugenics and human genetics. He carried out a study of twins separated at birth that seemed to indicate a strong hereditary component to [[I.Q.]] Muller was critical of the new directions of the eugenics movement (such as anti-immigration), but was hopeful about the prospects for positive eugenics.<ref>Carlson, ''Genes, Radiation, and Society'', pp 120-140</ref> ==Discovery of X-ray mutagenesis== 1926 marked the beginning of a series of major breakthroughs. Beginning in November, Muller carried out two experiments with varied doses of X-rays, the second of which used the crossing over suppressor stock ("ClB") he had found in 1919. A clear, quantitative connection between radiation and lethal mutations quickly emerged. Muller's discovery created a media sensation after he delivered a paper entitled "The Problem of Genetic Modification" at the Fifth International Congress of Genetics in [[Berlin]]; it would make him one of the better known public intellectuals of the early 20th century. By 1928, others had replicated his dramatic results, expanding them to other [[model organism]]s such as [[wasp]]s and [[maize]]. In the following years, he began publicizing the likely dangers of radiation exposure in humans (such as physicians who frequently operate X-ray equipment).<ref>Carlson, ''Genes, Radiation, and Society'', pp 141-164</ref> His lab grew quickly, but it shrunk again following the onset of the [[Great Depression]]. Especially after the stock market crash, Muller was increasingly pessimistic about the prospects of [[capitalism]]. Some of his visiting lab members were from the [[USSR]], and he helped edit and distribute an illegal leftist student newspaper, ''The Spark''. It was a difficult period for Muller both scientifically and personally: his marriage was falling apart, and he was increasingly dissatisfied with his life in Texas. Meanwhile, the waxing of the eugenics movement, ironically hastened by his own work pointing to the previously ignored connections between environment and genetics, meant that his ideas on the future of human evolution had reduced impact in the public sphere.<ref>Carlson, ''Genes, Radiation, and Society'', pp 165-183</ref> ==Work in Europe== In September of 1932, Muller moved to [[Berlin]] to work with the Russian expatriate geneticist [[Nikolay Timofeeff-Ressovsky]]; a trip intended as a limited sabbatical stretched into an eight year, five country journey. In Berlin, he met two physicists who would later be significant to the biology community: [[Niels Bohr]] and [[Max Delbrück]]. The Nazi movement was precipitating the rapid emigration of scientific talent from Germany, and Muller was particularly opposed to the politics of National Socialism. But the FBI was investigating Muller because of his involvement with ''The Spark'', so he chose instead to go to the Soviet Union (an environment better suited to his political beliefs). In 1933, Muller and his wife reconciled, and she and their son [[David E. Muller]] moved with Hermann to [[Leningrad]]. There, at the Institute of Genetics, he imported the basic equipment for a ''Drosophila'' lab&mdash;including the flies&mdash;and set up shop. The Institute was moved to [[Moscow]] in 1934, and Muller and his wife were divorced in 1935.<ref>Carlson, ''Genes, Radiation, and Society'', pp 184-203</ref> In the USSR, Muller supervised a large and productive lab, and organized work on medical genetics. Most of his work involved further explorations of genetics and radiation. There he completed his eugenics book, ''Out of the Night''. By 1936, however, [[Stalin]]'s repressive policies and the rise of [[Lysenkoism]] was making the USSR an increasingly problematic place to live and work. Muller and much of the Russian genetics community did what they could to oppose [[Trofim Lysenko]] and his [[Lamarckism|Larmarckian]] evolutionary theory, but Muller was soon forced to leave the Soviet Union after Stalin read a translation of his eugenics book and was "displeased by it, and...ordered an attack prepared against it."<ref>Carlson, ''Genes, Radiation, and Society'', pp 204-234; quotation from p 233, correspondence from Muller to Julian Huxley, March 9, 1937</ref> Muller&mdash;with about 250 strains of ''Drosophila''&mdash;moved to [[Edinburgh]] in September of 1937, after a brief stay in [[Madrid]] and [[Paris]]. In 1938, with war on the horizon, he began looking for a permanent position back in the United States. He also began courting Dorothea "Thea" Kantorowicz, a German refugee; they were married in May of 1939. The Seventh International Congress on Genetics was held in Edinburgh later that year; Muller wrote a "Geneticists' Manifesto" in response to the question: "How could the world's population be improved most effectively genetically?" He also engaged in a debate with the perennial genetics gadfly [[Richard Goldschmidt]] over the existence of the gene, for which there remained little direct physical evidence.<ref>Carlson, ''Genes, Radiation, and Society'', pp 235-273</ref> ==Later career== When Muller returned to the United States in 1940, he took an untenured research position at [[Amherst College]], in the department of [[Otto Glaser]]. After the U.S. entry into [[World War II]], his position was extended indefinitely and expanded to include teaching. His ''Drosophila'' work in this period focused on measuring the rate of spontaneous (as opposed to radiation-induced) mutations. Muller's publication rate decreased significantly in this period, from a combination of lack of lab workers and experimentally challenging projects. However, he also worked as an adviser to the [[Manhattan Project]] (though he did not know that was what it was), as well as a study of the mutational effects of [[radar]]. Muller's appointment was ended after the 1944-1945 academic year; despite difficulties stemming from his socialist political activities, he found a position as professor of zoology at [[Indiana University (Bloomington)|Indiana University]].<ref>Carlson, ''Genes, Radiation, and Society'', pp 274-288</ref> In 1946, Muller was awarded the [[1946]] [[Nobel Prize in Physiology or Medicine]], "for the discovery that mutations can be induced by x-rays". Genetics, and especially the physical and physiological nature of the gene, was becoming a central topic in biology, and x-ray mutagenesis was a key to many recent advances&mdash;among them, [[George Beadle]] and [[Edward Tatum]]'s work on ''[[Neurospora]]'' that established the [[one gene-one enzyme hypothesis]].<ref>Carlson, ''Genes, Radiation, and Society'', pp 304-318</ref> The Nobel Prize, in the wake of the [[atomic bombings of Hiroshima and Nagasaki]], focused public attention on a subject Muller had been publicizing for two decades: the dangers of radiation. In 1952, [[nuclear fallout]] became a public issue; since [[Operation Crossroads]], more and more evidence had been leaking out about [[radiation sickness]] and death caused by [[nuclear testing]], and Muller was one of the foremost experts. Muller&mdash;and many other scientists&mdash;pursued an array of political activities to defuse the threat of [[Nuclear warfare|nuclear war]]. With the [[Castle Bravo]] fallout controversy in 1954, the issue became even more urgent. In [[1955]] Muller was one of eleven prominent intellectuals to sign the [[Russell-Einstein Manifesto]], the upshot of which was the first [[Pugwash Conferences on Science and World Affairs|Pugwash Conference on Science and World Affairs]] in 1957.<ref>Carlson, ''Genes, Radiation, and Society'', pp 336-379</ref> H. J. Muller and science fiction writer [[Ursula Le Guin]] were [[second cousins]]; their great grandfather Nicholas Müller immigrated to the United States in 1848.<ref>Carlson, ''Genes, Radiation, and Society'', pp 10-11</ref> ==Family== Muller is survived by his daughter, Helen J. Muller, now an Emeritus professor at the University of New Mexico, and his son, [[David E. Muller]], a math professor at the University of Illinois and now an Emeritus professor at New Mexico State University. Dorothea Kantorowicz Muller was Helen Muller's mother, and Jessie Jacobs Muller was David Muller's mother. David E. Muller is the inventor of the Muller [[C-element]], a device used to implement asynchronous circuitry in electronic computers. ==Former graduate students== *[[H. Bentley Glass]] *[[C.P. Oliver]] *[[Wilson Stone]] *[[Elof Axel Carlson]] *[[Seymour Abrahamson]] *[[William Edgar Trout III]] *[[Dale Eugene Wagoner]] *[[Sara Helen Frye]] *[[Abraham P. Schalet]] *[[Irwin I. Oster]] ==Former post-doctoral fellows== *[[George D. Snell]] ==Worked in lab as undergraduates== *[[Carl Sagan]] *Margaret Edmondson ==List of Personnel who worked in his lab in Indiana== [http://www.indiana.edu/~liblilly/lilly/mss/subfile/mullerindiana.html] ==Notes== {{reflist|2}} ==References== *[[Elof Axel Carlson]], ''Genes, radiation, and society: the life and work of H.J. Muller'' (Ithaca, New York : Cornell University Press, 1981). ISBN 0-8014-1304-4 *[http://nobelprize.org/medicine/laureates/1946/muller-bio.html Nobel Biography] ==Further reading== *Herman Joseph Muller, '' Modern Concept of Nature'' (SUNY Press, 1973). ISBN 0-87395-096-8 *Herman Joseph Muller, ''Man's Future Birthright'' (SUNY Press, 1973). ISBN 0-87395-097-6 ==See also== *[[Muller's ratchet]] *[[Muller's morphs]] *[[History of biology]] *[[History of genetics]] *[[History of model organisms]] ==External links== *[http://crishunt.8bit.co.uk/muller_hermann_joseph.html Muller, Hermann Joseph] *[http://ca.geocities.com/med_2005perv/muller-bio.html Hermann J. Muller – Biography] {{academia |teachers=[[Thomas Hunt Morgan]] |students=[[H. Bentley Glass]] }} {{Nobel Prize in Physiology or Medicine Laureates 1926-1950}} {{DEFAULTSORT:Muller, Hermann Joseph}} [[Category:Biophysicists]] [[Category:Radiobiology]] [[Category:Radiation health effects researchers]] [[Category:American biologists]] [[Category:American geneticists]] [[Category:Jewish American scientists]] [[Category:Jewish atheists]] [[Category:American atheists]] [[Category:American humanists]] [[Category:American eugenicists]] [[Category:Guggenheim Fellows]] [[Category:Nobel laureates in Physiology or Medicine]] [[Category:Indiana University faculty]] [[Category:University of Texas at Austin faculty]] [[Category:Amherst College faculty]] [[Category:Columbia University alumni]] [[Category:1890 births]] [[Category:1967 deaths]] [[ar:هرمان مولر]] [[ca:Hermann Joseph Muller]] [[de:Hermann Joseph Muller]] [[es:Hermann Joseph Muller]] [[fr:Hermann Joseph Muller]] [[hr:Hermann Joseph Muller]] [[id:Hermann Joseph Muller]] [[it:Hermann Joseph Muller]] [[he:הרמן מולר]] [[nl:Hermann Joseph Muller]] [[ja:ハーマン・J・マラー]] [[pl:Hermann Joseph Muller]] [[pt:Hermann Joseph Muller]] [[ru:Мёллер, Герман Джозеф]] [[fi:Hermann Joseph Muller]] [[sv:Hermann Joseph Muller]] [[tr:Hermann Joseph Muller]] [[zh:赫尔曼·约瑟夫·马勒]]