Hippocampal sclerosis
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2007-08-31T21:54:05Z
169.2.161.2
'''Formaida Sclerosis''' or '''Ammon's horn sclerosis''' (AHS) is the most common type of [[Neuropathology|neuropathological]] damage seen in individuals with [[temporal lobe epilepsy]] (TLE). This type of [[neuron]] cell loss, primarily in the [[hippocampus]], can be observed in approximately 65% of people suffering from this form of [[epilepsy]].
[[Histopathology|Histopathological]] hallmarks of hippocampal sclerosis include segmental loss of pyramidal neurons, granule cell dispersion and reactive gliosis.
Hippocampal sclerosis was first described in [[1880]] by Sommer.
A long and ongoing debate addresses the issue of whether hippocampal sclerosis is the cause or the consequence of chronic, pharmacoresistant seizure activity.
Hippocampal sclerosis is nowadays easy to detect with MRI.
==References==
Blümcke, I.; Thom, M.; Wiestler, O.D. Ammon’s Horn Sclerosis: A Maldevelopmental
Disorder Associated with Temporal Lobe Epilepsy. Brain Pathol 2002;12:199-211.
Sommer W : Erkrankung des Ammon's horn als aetiologis ches moment der epilepsien. Arch Psychiatr Nurs 1880; 10 : 631-675.
==See also==
* [[epilepsy]]
* [[hippocampi]]
* [[temporal lobe epilepsy]]
[[Category:Diseases]]
[[Category:Epilepsy]]
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