ICAM-1 4460532 224268249 2008-07-08T02:11:31Z ProteinBoxBot 3991663 Replaced protein Box Template with PBB Template for easy viewing. {{see also|Cell adhesion molecule}} {{PBB|geneid=3383}} '''ICAM-1''' is a type of [[intercellular adhesion molecule]] continuously present in low concentrations in the membranes of leukocytes and endothelial cells. Upon cytokine stimulation, the concentrations greatly increase. ICAM-1 can be induced by [[interleukin-1]] (IL-1) and [[tumor necrosis factor alpha]] (TNFα) and is expressed by the vascular endothelium, [[macrophages]] and [[lymphocytes]]. ICAM-1 is a ligand for [[LFA-1]] ([[integrin]]), a receptor found on leukocytes. When activated, leukocytes binds to endothelial cells via ICAM-1/[[LFA-1]] and then transmigrates into tissues{{Entrez Pubmed|15811956}}. ICAM-1 has been implicated in [[subarachnoid hemorrhage]] (SAH). Levels of ICAM-1 are shown to be significantly elevated in patients with SAH over control subjects in many studies.<ref>Polin RS, Bavbek M, Shaffrey ME, Billups K, Bogaev CA, Kassell NF, Lee KS: Detection of soluble E-selectin, ICAM-1, VCAM-1 and L-selectin in the cerebrospinal fluid of patients after subarachnoid hemorrhage. '''Journal of Neurosurgery''' 89:559-567,1998.{{Entrez Pubmed|9761049}}</ref> <ref>Frijns CJM, Kappelle LJ: Inflammatory Cell Adhesion Molecules in Ischemic Cerebrovascular Disease. '''Stroke''' 33:2115-2122,2002. {{Entrez Pubmed|12154274}}</ref> While ICAM-1 has not been shown to be directly correlated with cerebral [[vasospasm]], a secondary insult which affects 70% of SAH patients, treatment with anti-ICAM-1 reduced the severity of vasospasm. ==References== {{reflist|2}} ==Further reading== {{refbegin | 2}} {{PBB_Further_reading | citations = *{{cite journal | author=Wahl SM, Greenwell-Wild T, Hale-Donze H, ''et al.'' |title=Permissive factors for HIV-1 infection of macrophages. |journal=J. Leukoc. Biol. |volume=68 |issue= 3 |pages= 303–10 |year= 2000 |pmid= 10985244 |doi= }} *{{cite journal | author=Yonekawa K, Harlan JM |title=Targeting leukocyte integrins in human diseases. |journal=J. Leukoc. Biol. |volume=77 |issue= 2 |pages= 129–40 |year= 2005 |pmid= 15548573 |doi= 10.1189/jlb.0804460 }} *{{cite journal | author=Chakravorty SJ, Craig A |title=The role of ICAM-1 in Plasmodium falciparum cytoadherence. |journal=Eur. J. Cell Biol. |volume=84 |issue= 1 |pages= 15–27 |year= 2005 |pmid= 15724813 |doi= }} *{{cite journal | author=Lebedeva T, Dustin ML, Sykulev Y |title=ICAM-1 co-stimulates target cells to facilitate antigen presentation. |journal=Curr. Opin. Immunol. |volume=17 |issue= 3 |pages= 251–8 |year= 2005 |pmid= 15886114 |doi= 10.1016/j.coi.2005.04.008 }} }} *{{cite journal | author=Yang L, Froio RM, Sciuto TE, Dvorak AM, Alon R, Luscinskas FW |title=ICAM-1 regulates neutrophil adhesion and transcellular migration of TNF-alpha-activated vascular endothelium under flow. |journal=Blood. |volume=106 |issue= 2 |pages= 584–92 |year= 2005 |pmid= 15811956 |doi= 10.1182/blood-2004-12-4942 }} }} {{refend}} ==External links== * {{MeshName|Intercellular+Adhesion+Molecule-1}} {{biochemistry-stub}} {{Clusters of differentiation}} {{Cell adhesion molecules}} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. --> {{PBB_Controls | update_page = yes | require_manual_inspection = no | update_protein_box = yes | update_summary = no | update_citations = yes }}