Indapamide 725051 217329649 2008-06-05T15:44:05Z Lennert B 558535 {{drugbox | IUPAC_name = 4-chloro-N-(2-methyl-2,3-dihydroindol-1-yl)- 3-sulfamoyl-benzamide | image = Indapamide.svg | width = 192 | CAS_number = 26807-65-8 | ATC_prefix = C03 | ATC_suffix = BA11 | ATC_supplemental = | PubChem = 3702 | DrugBank = APRD01031 | C=16 | H=16 | Cl=1 | N=3 | O=3 | S=1 | molecular_weight = 365.835 g/mol | bioavailability = | protein_bound = 71-79% | metabolism = Hepatic | elimination_half-life = 14-18 hours | pregnancy_category = | legal_status = | routes_of_administration = Oral }} '''Indapamide''' is a non-thiazide sulphonamide [[diuretic]] [[medication|drug]] marketed by [[Servier]], generally used in the treatment of [[hypertension]], as well as [[edema]] caused by [[congestive heart failure]]. Indapamide is marketed as Natrilix SR (sustained release). Combination preparations with [[perindopril]] (an [[ACE inhibitor]] antihypertensive) are also available. == Form and composition == Each sustained-release coated tablet contains 1.5 mg of 1-(4-chloro-3-sulfamyl-benzamido)-2-methylindoline (or indapamide hemihydrate). == Indications == Essential hypertension. == Dosage and administration == One tablet daily. == Contraindications == Indapamide is contraindicated in known hypersensitivity to [[sulfonamide]]s, severe [[renal failure]], [[hepatic encephalopathy]] or severe [[liver failure|hepatic failure]] and [[hypokalemia]] (low blood potassium levels). There is insufficient safety data to recommend indapamide use in [[pregnancy]] or [[breastfeeding]]. == Interactions == Caution is advised in the combination of indapamide with [[lithium]] and nonantiarrhythmic drugs causing wave burst arrhythmia (astemizole, bepridil, IV erythromycin, halofantrine, pentamidine, sultopride, terfenadine, vincamine). == Precautions == Monitoring of potassium and uric acid serum levels is recommended, especially in subjects with a predisposition or a sensitivity to hypokalemia and in patients with gout. == Adverse effects == Commonly reported [[adverse event]]s are hypokalemia (low potassium levels), [[fatigue (medical)|fatigue]], [[orthostatic hypotension]] (blood pressure decrease on standing up) and allergic manifestations. == Overdosage == Symptoms of overdosage would be those associated with a diuretic effect: electrolyte disturbances, hypotension, and muscular weakness. Treatment should be symptomatic, directed at correcting the electrolyte abnormalities. {{Antihypertensives and diuretics}} [[Category:Thiazides]] [[hr:Indapamid]] [[hu:Indapamid]] [[it:Indapamide]] [[ja:インダパミド]] [[pl:Indapamid]]