Indapamide
725051
217329649
2008-06-05T15:44:05Z
Lennert B
558535
{{drugbox
| IUPAC_name = 4-chloro-N-(2-methyl-2,3-dihydroindol-1-yl)- 3-sulfamoyl-benzamide
| image = Indapamide.svg
| width = 192
| CAS_number = 26807-65-8
| ATC_prefix = C03
| ATC_suffix = BA11
| ATC_supplemental =
| PubChem = 3702
| DrugBank = APRD01031
| C=16 | H=16 | Cl=1 | N=3 | O=3 | S=1
| molecular_weight = 365.835 g/mol
| bioavailability =
| protein_bound = 71-79%
| metabolism = Hepatic
| elimination_half-life = 14-18 hours
| pregnancy_category =
| legal_status =
| routes_of_administration = Oral
}}
'''Indapamide''' is a non-thiazide sulphonamide [[diuretic]] [[medication|drug]] marketed by [[Servier]], generally used in the treatment of [[hypertension]], as well as [[edema]] caused by [[congestive heart failure]]. Indapamide is marketed as Natrilix SR (sustained release). Combination preparations with [[perindopril]] (an [[ACE inhibitor]] antihypertensive) are also available.
== Form and composition ==
Each sustained-release coated tablet contains 1.5 mg of 1-(4-chloro-3-sulfamyl-benzamido)-2-methylindoline (or indapamide hemihydrate).
== Indications ==
Essential hypertension.
== Dosage and administration ==
One tablet daily.
== Contraindications ==
Indapamide is contraindicated in known hypersensitivity to [[sulfonamide]]s, severe [[renal failure]], [[hepatic encephalopathy]] or severe [[liver failure|hepatic failure]] and [[hypokalemia]] (low blood potassium levels).
There is insufficient safety data to recommend indapamide use in [[pregnancy]] or [[breastfeeding]].
== Interactions ==
Caution is advised in the combination of indapamide with [[lithium]] and nonantiarrhythmic drugs causing wave burst arrhythmia (astemizole, bepridil, IV erythromycin, halofantrine, pentamidine, sultopride, terfenadine, vincamine).
== Precautions ==
Monitoring of potassium and uric acid serum levels is recommended, especially in subjects with a predisposition or a sensitivity to hypokalemia and in patients with gout.
== Adverse effects ==
Commonly reported [[adverse event]]s are hypokalemia (low potassium levels), [[fatigue (medical)|fatigue]], [[orthostatic hypotension]] (blood pressure decrease on standing up) and allergic manifestations.
== Overdosage ==
Symptoms of overdosage would be those associated with a diuretic effect: electrolyte disturbances, hypotension, and muscular weakness. Treatment should be symptomatic, directed at correcting the electrolyte abnormalities.
{{Antihypertensives and diuretics}}
[[Category:Thiazides]]
[[hr:Indapamid]]
[[hu:Indapamid]]
[[it:Indapamide]]
[[ja:インダパミド]]
[[pl:Indapamid]]