Interstitial lung disease 1483290 221461078 2008-06-24T16:29:49Z 81.187.242.138 /* External links */ {{Unreferenced|date=January 2008}} {{DiseaseDisorder infobox | Name = {{PAGENAME}} | ICD10 = {{ICD10|J|84|9|j|80}} | ICD9 = {{ICD9|506.4}}, {{ICD9|508.1}}, {{ICD9|515}}, {{ICD9|516.3}}, {{ICD9|714.81}}, {{ICD9|770.7}} | ICDO = | Image = honeycomb.jpg | Caption = End-stage pulmonary fibrosis of unknown origin, taken from an autopsy in the 1980s. | OMIM = | MedlinePlus = | eMedicineSubj = ped | eMedicineTopic = 1950 | DiseasesDB = 31509 | MeshID = D017563 | }} '''Interstitial lung disease (ILD)''', also known as '''diffuse parenchymal lung disease (DPLD)''', refers to a group of [[lung]] diseases (including [[idiopathic pulmonary fibrosis]]), affecting the [[Pulmonary alveolus|alveolar]] [[epithelium]], pulmonary [[capillary]] [[endothelium]], [[basement membrane]], perivascular and perilymphatic tissues. The term ILD is used to distinguish these diseases from [[obstructive airways diseases]]. Most types of ILD involve [[fibrosis]], but this is not essential; indeed fibrosis is often a later feature. Hence the term '''''pulmonary fibrosis''''' has fallen out of favor. == Causes == [[Image:Usual interstitial pneumonia (1).JPG|right|239px|thumb|[[Micrograph]] of [[usual interstitial pneumonia]] (UIP). UIP is the most common pattern of [[idiopathic interstitial pneumonia]] (a type of interstitial lung disease) and usually represents [[idiopathic pulmonary fibrosis]]. [[H&E stain]]. [[Autopsy]] specimen.]] ILD may be classified according to the cause: - # Inhaled substances #* Inorganic #** [[Silicosis]] #** [[Asbestosis]] #** [[Berylliosis]] #* Organic #** [[Hypersensitivity pneumonitis]] # Drug induced #* [[Antibiotic]]s #* [[Chemotherapy|Chemotherapeutic drugs]] #* [[Antiarrhythmic agents]] # Connective tissue disease #* [[Systemic sclerosis]] #* [[Dermatomyositis]] #* [[Systemic lupus erythematosus]] #* [[Rheumatoid arthritis]] # Infection #* [[Atypical pneumonia]] #* [[Pneumocystis pneumonia (PCP)]] #* [[Tuberculosis]] # Idiopathic #* [[Sarcoidosis]] #* [[Idiopathic pulmonary fibrosis]] #* [[Hamman-Rich syndrome]] # Malignancy #* Lymphangitic [[carcinoma]]tosis == Investigation == [[Image:PCP CAP CXR.JPG|right|thumb|Patients with [[Pneumocystis pneumonia (PCP)|pneumocystis pneumonia]] can present with interstitial lung disease, as seen in the reticular markings on this AP [[chest x-ray]]]] Investigation is tailored towards the symptoms and signs. Most patients have blood testing, chest [[x-ray]], pulmonary function testing, and high resolution [[computerized tomography|CT]] thorax. A lung [[biopsy]] is required if the clinical history and imaging is not clearly suggestive of a specific diagnosis or [[cancer|malignancy]] cannot otherwise be ruled-out. == Treatment == ILD is not a single disease, but encompasses many different pathological processes. Hence treatment is different for each disease. If a specific occupational exposure cause is found, the person should avoid that environment. If a [[Medication|drug]] cause is suspected, that drug should be discontinued. Many [[idiopathic]] and [[connective tissue]]-based causes of ILD are treated with [[prednisolone]]. Some patients respond to [[immunosuppressant]] treatment. Patients with [[Hypoxia (medical)|hypoxemia]] may be given supplemental [[oxygen]]. == External links == * [http://pulmonary.ucsf.edu/activities/ild.html '''University of California, San Francisco Interstitial Lung Disease Center of Excellence'''] * [http://www.coalitionforpf.org/index.html Coalition for Pulmonary Fibrosis - Research, Education, Support & Hope] *[http://www.pulmonaryfibrosis.org/ipf.htm What is Pulmonary Fibrosis?] * {{Chorus|00736}} * {{GPnotebook|1476788304}} * {{MeshName|Pulmonary+Fibrosis}} * {{MedlinePlusOverview|pulmonaryfibrosis}} * [http://www.aimip.org/ AIMIP - Italian Association for IPF - Associazione Italiana] * [http://simmonscenterild.upmc.com/Default.htm '''Dorothy P. and Richard P. Simmons Center for Interstitial Lung Diseases'''] * [http://www.uchospitals.edu/specialties/pulmonary/interstitial-lung/index.html University of Chicago Interstitial Lung Disease Program] * [http://paipf.medicine.pitt.edu/default.asp '''PA-IPF''' - The Pennsylvania Idiopathic Pulmonary Fibrosis State Registry] * [http://www.uclungfibrosis.com '''University of Cincinnati Interstitial Lung Disease Center'''] * [http://www.huff-n-puff.net Huff'n'Puff - Interstitial lung disease support and information site] {{Respiratory pathology}} [[Category:Pulmonology]] {{disease-stub}} [[de:Interstitielle Lungenerkrankung]] [[es:Enfermedad pulmonar intersticial]] [[id:Penyakit paru interstisial]] [[ja:間質性肺炎]] [[fi:Keuhkoparenkyymisairaudet]]