Iodide 519796 212682186 2008-05-15T20:23:47Z Shinkolobwe 5641591 See also + 3 links to web pages. {{dablink|"i-" redirects here. For the [[Internet-related prefix]] i-, see Wiktionary's entry [[wikt:i-|i-]].}} An '''iodide''' [[ion]] is an [[iodine|iodine atom]] with a &minus;1 [[electric charge|charge]] <ref>{{Greenwood&Earnshaw}}</ref>. Compounds with iodine in formal [[oxidation state]] &minus;1 are called '''iodides'''. This can include [[ion]]ic compounds such as [[caesium iodide]] or [[covalent]] compounds such as [[carbon tetraiodide]]. This is the same naming scheme as is seen with [[chloride]]s and [[bromide]]s. The chemical test for an iodide compound is to acidify the aqueous compound by adding some drops of [[acid]], to dispel any carbonate ions present, then adding [[lead(II) nitrate]], yielding a bright yellow [[precipitate]] of [[lead iodide]]. Most ionic iodides are soluble, with the exception of yellow [[silver iodide]] and yellow [[lead iodide]]. Aqueous solutions of iodide dissolve iodine better than pure water due to the formation of [[complex ion]]s: :I<sup>−</sup>(aq) + I<sub>2</sub>(s) {{unicode|⇌}} I<sub>3</sub><sup>−</sup>(aq) The colour of new [[triiodide]] ions formed are brown. ==Examples== Examples or common iodides include: * [[hydrogen iodide]] (HI) * [[sodium iodide]] (NaI) * [[potassium iodide]] (KI) * [[carbon tetraiodide]] (CI<sub>4</sub>) * [[silver iodide]] (AgI) * [[nitrogen triiodide]] (NI<sub>3</sub>) ==Iodide as an antioxidant== Iodide can function as an antioxidant as it is a [[redox|reducing]] species that can detoxify [[reactive oxygen species]] such as [[hydrogen peroxide]]. Over three billion years ago, [[cyanobacteria|blue-green algae]] were the most primitive oxygenic [[photosynthesis|photosynthetic]] organisms and are the ancestors of multicellular [[eukaryotic]] algae (1). Algae that contain the highest amount of iodine (1-3 % of dry weight) and peroxidase enzymes, were the first living cells to produce poisonous oxygen in the atmosphere <ref>Küpper FC, Feiters MC, Meyer-Klaucke W, Kroneck PMH, Butler A (2002) Iodine Accumulation in Laminaria (Phaeophyceae): an Inorganic Antioxidant in a Living System? Proceedings of the 13th Congress of the Federation of European Societies of Plant Physiology, Heraklion, Greece, September 2-6, p. 571</ref><ref>Küpper FC, Schweigert N, Ar Gall E, Legendre J-M, Vilter H, Kloareg B (1998) Iodine uptake in Laminariales involves extracellular, haloperoxidase-mediated oxidation of iodide. Planta 207:163-171</ref>. Therefore algal cells required a protective antioxidant action of their molecular components, in which iodides, through peroxidase enzymes, seem to have had this specific role <ref>Ar Gall, E., Küpper, F.C. & Kloareg, B. (2004). A survey of iodine content in Laminaria digitata. Botanica Marina 47: 30-37.</ref><ref>Küpper FC et al. (2008) Iodide accumulation provides kelp with an inorganic antioxidant impacting atmospheric chemistry. Proc Natl Acad Sci U S A. May 5 . N PMID: 18458346</ref> <ref>Venturi S, Donati FM, Venturi A, Venturi M. Environmental iodine deficiency: A challenge to the evolution of terrestrial life? Thyroid. 2000 Aug;10(8):727-9. PMID: 11014322 </ref>. In fact, iodides are greatly present and available in the sea, where algal phytoplankton, the basis of marine food-chain, acts as a biological accumulator of iodides, selenium, (and n-3 fatty acids) <ref>Venturi S. and Venturi M. “Iodine and Evolution”. DIMI-MARCHE NEWS, Dipartimento Interaziendale di Medicina Interna della Regione Marche (Italy), published on-line, Feb. 8, 2004: http://web.tiscali.it/iodio/</ref><ref>Venturi S, Donati FM, Venturi A, Venturi M, Grossi L, Guidi A. Role of iodine in evolution and carcinogenesis of thyroid, breast and stomach. Adv Clin Path. 2000 Jan;4(1):11-7. PMID: 10936894</ref> <ref>Venturi S, Venturi M. Evolution of Dietary Antioxidant Defences. European EPI-Marker. 2007, 11, 3 :1-12</ref>: '''Antioxidant biochemical mechanism of iodides''' <ref>Venturi S, Venturi M. Iodide, thyroid and stomach carcinogenesis: evolutionary story of a primitive antioxidant? Eur J Endocrinol. 1999 Apr;140(4):371-2. N PMID: 10097259</ref> :2 I<sup>−</sup> → I<sub>2</sub> + 2 e<sup>−</sup> (electrons) = −0.54 Volt ; :2 I<sup>−</sup> + Peroxidase + H<sub>2</sub>O<sub>2</sub> + 2 Tyrosine → 2 Iodo-Tyrosine + H<sub>2</sub>O + 2 e<sup>−</sup> (antioxidants); :2 e<sup>−</sup> + H<sub>2</sub>O<sub>2</sub> + 2 H<sup>+</sup> (of intracellular water-solution) → 2 H<sub>2</sub>O Antioxidant biochemical mechanism of iodides, probably one of the most ancient mechanisms of defense from poisonous reactive oxygen species: :2 I<sup>−</sup> + Peroxidase + H<sub>2</sub>O<sub>2</sub> + Tyrosine, Histidine, Lipids, Carbons -> Iodo-Compounds + H<sub>2</sub>O + 2 e<sup>−</sup> (antioxidants) Iodo-Compounds: Iodo-Tyrosine, Iodo-Histidine, Iodo-Lipids, Iodo-Carbons. ==Clinical Use== Iodide (>6mg/day) can be used to treat patients with [[hyperthyroidism]] due to its ability to block the release of [[thyroid hormone]] (TH), known as the Wolff-Chaikoff Effect, from the [[thyroid gland]]. In fact, prior to [[1940]], iodides were the predominant antithyroid agents. In large doses, iodides inhibit [[proteolysis]] of [[thyroglobulin]]. This permits TH to be synthesized and stored in [[colloid]], but not released into the bloodstream. Of note, this treatment is seldom used today as a stand-alone therapy despite the rapid improvement of patients immediately following administration. The major disadvantage of iodide treatment lies in the fact that excessive stores of TH accumulate, slowing the onset of action of [[thioamides]] (TH synthesis blockers). Additionally, the functionality of iodides fade after the initial treatment period. An "escape from block" is also a concern, as extra stored TH may spike following discontinuation of treatment. ==See also== *{{Cite web | title = Seaweed use iodine as an antioxidant | work = Chemistry World blog | accessdate = 2008-05-15 | url = http://prospect.rsc.org/blogs/cw/?p=956 }} *{{Cite web | title = Stressed seaweed contributes to cloudy coastal skies, study suggests | accessdate = 2008-05-15 | url = http://www.eurekalert.org/pub_releases/2008-05/uom-ssc050608.php }} *{{Cite web | title = Iodine Deficiency: studies by dr. Sebastiano Venturi (Italy) | accessdate = 2008-05-15 | url = http://web.tiscali.it/iodio/ }} == References == {{Reflist}} [[Category:Dietary minerals]] [[Category:Evolution]] [[Category:Nutrition]] [[Category:Dietary antioxidants]] [[Category:Anions]] [[Category:Iodides|*]] [[Category:Leaving group]] [[de:Iodide]] [[et:Jodiidid]] [[es:Yoduro]] [[fr:Ion iodure]] [[nl:Jodide]] [[ja:ヨウ化物]] [[ru:Иодиды]] [[fi:Jodidi]] [[tr:İyodür]] [[zh:碘化物]]