Janeway lesion 732593 225816460 2008-07-15T15:19:42Z 72.90.97.232 '''Janeway lesions''' are non-[[tender]], small [[erythematous]] or [[haemorrhagic]] [[macule|macular]] or [[nodule|nodular]] lesions on the [[palms]] or [[Sole (foot)|soles]] only a few millimeters in diameter that are [[pathognomonic]] of [[endocarditis|infective endocarditis]].<ref name = "Farrior">{{cite journal | last = Farrior | first = J.B. | coauthors = Silverman M.E. | title = A consideration of the differences between a Janeway's lesion and an Osler's node in infectious endocarditis |journal = Chest. | volume = 70 | issue = 2 | pages = 239–43 | year = 1976 | pmid = 947688 | doi = 10.1378/chest.70.2.239}}</ref> Pathologically, the lesion is described to be a [[abscess|microabscess]] of the [[dermis]] with marked [[necrosis]] and inflammatory infiltrate not involving the [[epidermis(skin)|epidermis]], which is due to the deposition of circulating [[immune complexes]] in small blood vessels.<ref name = "Farrior"/> They are named after [[Edward G. Janeway]] (1841&ndash;1911), a [[professor]] of [[medicine]] with interests in [[cardiology]] and [[infectious disease]].<ref>{{cite journal |author=Janeway C. |title=Presidential Address to The American Association of Immunologists. The road less traveled by: the role of innate immunity in the adaptive immune response |journal=J. Immunol. |volume=161 |issue=2 |pages=539–44 |year=1998 |pmid=9670925}}</ref> ==See also== *[[Osler's node]]s *[[Roth' s spot]]s ==References== <references/> {{Eponymous medical signs for circulatory and respiratory systems}} [[Category:Medical signs]] [[no:Janeways lesjon]]