Jeryl Lynn 4913671 215574167 2008-05-28T20:16:57Z DOI bot 6652755 Citation maintenance. You can [[WP:DOI|use this bot]] yourself! Please [[User:DOI_bot/bugs|report any bugs]]. '''Jeryl Lynn''' are strains of mumps virus used in the [[Mumpsvax]] [[mumps]] [[Mumps vaccine|vaccine]] made by [[Merck & Co.|Merck]]. The strains are named after '''Jeryl Lynn Hilleman'''. In 1963 Ms. Hilleman's father Dr. [[Maurice Hilleman]], was leading efforts to produce a [[mumps vaccine]] for Merck<!--presumably asking the Russians for some Leningrad-3 would have been too embarrassing to bear?-->. He cultured the Mumps virus from her throat, and in 1967 a vaccine was produced from this which is now widely used.<!-- --><ref name="WHO">{{cite web | author = World Health Organization | authorlink =World Health Organization | year = 1998 | month =March | url =http://www.who.int/vaccines-diseases/diseases/mumps_vaccine.shtml | title =The Mumps Vaccine | work =Immunization, Vaccines and Biologicals | accessdate =2006-05-24}}</ref> The Jeryl Lynn strains used in the manufacture of Mumpsvax later turned out to contain two distinguishable viral substrains, ''JL1'' and ''JL2''.<!-- --><ref name="Amexis_2001">{{cite journal | author=Amexis G, Oeth P, Abel K, Ivshina A, Pelloquin F, Cantor C, Braun A, Chumakov K, Brau A | title=Quantitative mutant analysis of viral quasispecies by chip-based matrix-assisted laser desorption/ ionization time-of-flight mass spectrometry. | journal=Proc Natl Acad Sci U S A | volume=98 | issue=21 | pages=12097–102 | year=2001 | pmid=11593021 | url=http://www.pubmedcentral.gov/articlerender.fcgi?tool=pubmed&pubmedid=11593021 | doi=10.1073/pnas.211423298}}</ref> Further research showed that the JL1 strain was preferentially selected by propagation in [[Vero cell|Vero]] and [[CEF]] [[cell cultures]]. The JL2 strain was preferentially selected by passage in embryonated chicken eggs.<!-- --><ref name="Amexis_2002">{{cite journal | author=Amexis G, Rubin S, Chizhikov V, Pelloquin F, Carbone K, Chumakov K | title=Sequence diversity of Jeryl Lynn strain of mumps virus: quantitative mutant analysis for vaccine quality control. | journal=Virology | volume=300 | issue=2 | pages=171–9 | year=2002 | pmid=12350348 | doi=10.1006/viro.2002.1499}} * Complete genome of JL1 - {{cite journal|url=http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=15077508|title=Mumps virus (STRAIN JERYL-LYNN) live vaccine major component, complete genome|author=Amexis,G., Rubin,S., Chizhikov,V., Pelloquin,F., Carbone,K., Chumakov,K.|year=2002|journal=Virology}} * Complete genome of JL2 - {{cite journal|url=http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=19070168|title=Mumps virus (STRAIN JERYL-LYNN) live vaccine minor component JL2, complete genome|author=Amexis,G., Rubin,S., Chizhikov,V., Pelloquin,F., Carbone,K., Chumakov,K.|year=2002|journal=Virology}}</ref> In the U.S.A. the Jeryl Lynn strain-based vaccines supplanted the previous, killed virus, vaccine in 1978.<!-- --><ref name="WHO"/> ==References== <references/> ==See also== * [[Mumpsvax]] * [[MMR Vaccine]] * Dr. [[Maurice Hilleman]] * [[Vaccine controversy]] {{vaccines}} [[Category:Vaccines]]