Lactic acidosis 249961 218258279 2008-06-09T21:17:31Z 74.248.65.41 {{Expand|date=May 2007}} {{Infobox_Disease | Name = Lactic acidosis | Image = Lactic-acid-skeletal.png | Caption = [[Lactic acid]] | DiseasesDB = 29145 | ICD10 = {{ICD10|E|87|2|e|70}} | ICD9 = {{ICD9|276.2}} | ICDO = | OMIM = | MedlinePlus = 000391 | eMedicineSubj = med | eMedicineTopic = 1253 | MeshName = Lactic+Acidosis | MeshNumber = C18.452.076.176.180 | }} '''Lactic acidosis''' is a condition caused by the buildup of [[lactic acid]] in the body. It leads to acidification of the blood ([[acidosis]]), and is considered a distinct form of [[metabolic acidosis]].<ref name="Luft">{{cite journal | last=Luft | first=FC | title=Lactic acidosis update for critical care clinicians | journal=Journal of the American Society of Nephrology | volume=12 | issue=Suppl. 17 | pages=15–19 | publisher=American Society of Nephrology | date=February 2001 | url=http://jasn.asnjournals.org/cgi/content/full/12/suppl_1/S15 | pmid=11251027 | accessdate=2008-05-28 }}</ref> The cells produce lactic acid when they use [[glucose]] for energy in the absence of adequate [[oxygen]]. If too much lactic acid stays in the body, the balance tips and the person begins to feel ill. The signs of lactic acidosis are deep and rapid breathing, vomiting, and abdominal pain. Lactic acidosis may be caused by [[diabetic ketoacidosis]] or [[liver]] or [[kidney]] disease, as well as some forms of medication (most notably the anti-diabetic drug [[metformin]]). Some anti-HIV drugs ([[antiretroviral]]s) warn doctors in their prescribing information to regularly watch for symptoms of lactic acidosis caused by [[mitochondrial toxicity]]. ==Classification== The ''Cohen-Woods classification'' categorises causes of lactic acidosis as follows:<ref name="isbn0-632-09460-5">{{cite book |author=Woods, Hubert Frank; Cohen, Robert |title=Clinical and biochemical aspects of lactic acidosis |publisher=Blackwell Scientific |location=Oxford |year=1976 |pages= |isbn=0-632-09460-5 |oclc= |doi= |accessdate=}}</ref> * Type A: Decreased perfusion or oxygenation * Type B: ** B1: Underlying diseases (sometimes causing type A) ** B2: Medication or intoxication ** B3: [[Inborn error of metabolism]] ==Associated conditions== Lactic acidosis is an underlying process of [[rigor mortis]]. Tissue in the muscles of the deceased resort to anaerobic metabolism in the absence of oxygen and significant amounts of lactic acid are released into the muscle tissue. This along with the loss of [[adenosine triphosphate|ATP]] causes the muscles to grow stiff. ==See also== * [[Metabolic acidosis]] ==References== <references/> * Clinical Physiology of Acid-Base and Electrolyte Disorders by Rose, Post * Intensive Care Medicine by Irwin and Rippe * The ICU Book by Marino {{Fluid, electrolyte, acid base metabolic pathology}} [[Category:Electrolyte disturbance]] [[Category:Medical emergencies]] {{med-stub}} [[de:Laktatazidose]] [[es:Acidosis láctica]] [[it:Acidosi lattica]] [[pl:Kwasica mleczanowa]] [[pt:Acidose láctica]] It can also be present at birth. So it is important to get checked if the baby has any symptoms.