Lansoprazole
1425463
225681517
2008-07-14T21:43:15Z
Mercenario97
4511633
/* External links */
{{Drugbox|
|IUPAC_name = 2-[(3-methyl-4-(2,2,2-trifluoroethoxy) pyridin-2-yl) methylsulfinyl] -1''H''-benzoimidazole
| image=Lansoprazole.svg
| image2 = Lansoprazole 3D.png
| width = 250px
| CAS_number=103577-45-3
| ATC_prefix=A02
| ATC_suffix=BC03
| ATC_supplemental=
| PubChem=3883
| DrugBank=APRD00077
| C = 16 | H = 14 | F = 3 | N = 3 | O = 2 | S = 1
| molecular_weight = 369.363 g/mol
| smiles = O=S(Cc1nccc(OCC(F)(F)F)c1C)c1nc2ccccc2[nH]1
| bioavailability= 80% or more
| protein_bound = 97%
| metabolism = [[Liver|Hepatic]] ([[CYP3A4]]- and [[CYP2C19]]-mediated)
| elimination_half-life= 1–1.5 hours
| excretion = [[Kidney|Renal]] and [[feces|fecal]]
| licence_US = Lansoprazole
| pregnancy_AU = B3
| pregnancy_US = B
| legal_status = Rx-only
| routes_of_administration= Oral, [[intravenous therapy|IV]]
}}
'''Lansoprazole''' (lan-SOE-pra-zole, [[International Nonproprietary Name|INN]]) is a [[proton pump inhibitor]] which prevents the stomach from producing acid. It is manufactured by a number of companies worldwide under several trade names. It was first approved by the [[Food and Drug Administration|FDA]] in 1995 [http://www.mosbysdrugconsult.com/DrugConsult/Top_200/Drugs/e3230.html].
==Pharmacology==
Lansoprazole is a [[proton pump inhibitor]] (PPI) in the same pharmacologic class as [[omeprazole]]. Lansoprazole has been marketed for many years and is one of several PPI's available.{{Fact|date=March 2007}} <!--It is expected to receive OTC approval (like Prilosec OTC) after its patent expires in [[2009]].{{Fact|date=March 2007}} Additionally - TAP Pharmaceuticals has reported their intent to file a s-isomer formulation of S-lansoprazole in a 60 mg dosage in 2009 after its parent compounds patent has expired in the [[United States]].{{Fact|date=March 2007}}-->
Lansoprazole's plasma elimination half-life is not proportional to the duration of the drug's effects (i.e. gastric acid suppression). The mean plasma elimination half-life is 1.5 hours,<ref name="RxList">{{cite web | url = http://www.rxlist.com/cgi/generic/lansop_cp.htm | title = Prevacid Pharmacology, Pharmacokinetics, Studies, Metabolism | year = 2007 | accessdate = 2007-04-14 | publisher = RxList.com}}</ref> and the effects of the drug last for over 24 hours after it has been used for 1 day or more.{{Fact|date=March 2007}}
==Indications==
Lansoprazole is indicated for:
*Treatment of [[ulcer]]s of the stomach and duodenum, and [[NSAID]]-induced ulcers
*Treatment of [[gastroesophageal reflux disease]] (GERD) (also known as ''acid reflux disease'')
*Treatment of [[Zollinger-Ellison Syndrome]]
*Adjunctive treatment of ''[[Helicobacter pylori]]'' infection, alongside [[antibiotics]]
==Drug Interactions==
*PPI’s reduce absorption of [[Antifungal drug|antifungals]] ([[itraconazole]] and [[ketoconazole]]) and possibly increase [[Digoxin]] in plasma
*Increases plasma concentrations of [[Cilostazol]] (risk of toxicity)
*Absorption of lansoprazole possibly reduced by:
** [[sucralfate]]
** [[ampicillin]]
** [[bisacodyl]]
** [[delavirdine]]
** [[fluvoxamine]]
** iron salts
** [[theophylline]]
** [[voriconazole]]
** [[aminophylline]] and [[theophylline]]
** [[astemizole]]
==Side effects==
*'''Infrequent''': [[dry mouth]], [[insomnia]], [[drowsiness]], blurred [[Visual perception|vision]], [[rash]], [[pruritus]]
*'''Rarely and very rarely''': [[taste]] disturbance, [[liver]] dysfunction, [[oedema|peripheral oedema]], hypersensitivity reactions (including [[bronchospasm]], urinary, [[angioedema]], [[anaphylaxis]]), [[photosensitivity]], [[fever]], [[sweating]], [[clinical depression|depression]], [[interstitial nephritis]], blood disorders (including [[leukopenia]], [[leukocytosis]], [[pancytopenia]], [[thrombocytopenia]]), [[arthralgia]], [[myalgia]], skin reactions (including [[Stevens-Johnson syndrome]], [[toxic epidermal necrolysis]], [[blister|bullous eruption]])
*'''Severe''': Gastro-intestinal disturbances (such as [[nausea]] 1.3%, [[abdominal pain]] 2.1%, [[diarrhea]] 3.8%<ref name="RxList">{{cite web | url = http://www.rxlist.com/cgi/generic/fluoxetine_cp.htm | title = Prozac Pharmacology, Pharmacokinetics, Studies, Metabolism | year = 2007 | accessdate = 2007-04-14 | publisher = RxList.com}}</ref>
== Brand names ==
[[image:prevacid30mg.png|thumb|Prevacid 30 mg]]
The drug is sold under several brand names, including: [http://www.mosbysdrugconsult.com/DrugConsult/Top_200/Drugs/e3230.html]
* '''Aprazol''' (Turkey)
* '''Duogast''' (Syria)
* '''Lanpro''' (India)
* '''Lansox''' (Italy)
* '''Lanton''' (Israel)
* '''Lanzor''' (France)
* '''Laprazol''' (Greece)
* '''Limpidex''' (Italy)
* '''Ogast''' and '''OgastORO''' (France)
* '''Prevacid''' (U.S. and Canada) Prevacid is a product of [[TAP Pharmaceutical Products]].
* '''Prosogan''' and '''Prosogan FD''' (Indonesia)
* '''Refluxon''' (Hungary)
* '''SOLOX''' (New Zealand)
* '''Takepron''' (Japan)
* '''Zoton''' (Italy, Ireland, Australia, UK)
Lansoprazole is also available as a [[generic drug]] in the UK, Belgium, France, Colombia, Italy and Mexico.
== References ==
{{Reflist}}
== External links ==
* [http://www.prevacid.com Prevacid] (manufacturer's website)
* [http://www.prevakids.com Prevacid Pediatrics] (manufacturer's website)
* [http://www.tap.com/prd_prev.asp#prevpac Prevpac] (manufacturer's website)
{{Proton-Pump Inhibitors}}
[[Category:Proton pump inhibitors]]
[[Category:Benzimidazoles]]
[[Category:Sulfoxides]]
[[Category:Pyridines]]
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[[ru:Лансопразол]]
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