Lansoprazole 1425463 225681517 2008-07-14T21:43:15Z Mercenario97 4511633 /* External links */ {{Drugbox| |IUPAC_name = 2-[(3-methyl-4-(2,2,2-trifluoroethoxy) pyridin-2-yl) methylsulfinyl] -1''H''-benzoimidazole | image=Lansoprazole.svg | image2 = Lansoprazole 3D.png | width = 250px | CAS_number=103577-45-3 | ATC_prefix=A02 | ATC_suffix=BC03 | ATC_supplemental= | PubChem=3883 | DrugBank=APRD00077 | C = 16 | H = 14 | F = 3 | N = 3 | O = 2 | S = 1 | molecular_weight = 369.363 g/mol | smiles = O=S(Cc1nccc(OCC(F)(F)F)c1C)c1nc2ccccc2[nH]1 | bioavailability= 80% or more | protein_bound = 97% | metabolism = [[Liver|Hepatic]] ([[CYP3A4]]- and [[CYP2C19]]-mediated) | elimination_half-life= 1–1.5 hours | excretion = [[Kidney|Renal]] and [[feces|fecal]] | licence_US = Lansoprazole | pregnancy_AU = B3 | pregnancy_US = B | legal_status = Rx-only | routes_of_administration= Oral, [[intravenous therapy|IV]] }} '''Lansoprazole''' (lan-SOE-pra-zole, [[International Nonproprietary Name|INN]]) is a [[proton pump inhibitor]] which prevents the stomach from producing acid. It is manufactured by a number of companies worldwide under several trade names. It was first approved by the [[Food and Drug Administration|FDA]] in 1995 [http://www.mosbysdrugconsult.com/DrugConsult/Top_200/Drugs/e3230.html]. ==Pharmacology== Lansoprazole is a [[proton pump inhibitor]] (PPI) in the same pharmacologic class as [[omeprazole]]. Lansoprazole has been marketed for many years and is one of several PPI's available.{{Fact|date=March 2007}} <!--It is expected to receive OTC approval (like Prilosec OTC) after its patent expires in [[2009]].{{Fact|date=March 2007}} Additionally - TAP Pharmaceuticals has reported their intent to file a s-isomer formulation of S-lansoprazole in a 60 mg dosage in 2009 after its parent compounds patent has expired in the [[United States]].{{Fact|date=March 2007}}--> Lansoprazole's plasma elimination half-life is not proportional to the duration of the drug's effects (i.e. gastric acid suppression). The mean plasma elimination half-life is 1.5 hours,<ref name="RxList">{{cite web | url = http://www.rxlist.com/cgi/generic/lansop_cp.htm | title = Prevacid Pharmacology, Pharmacokinetics, Studies, Metabolism | year = 2007 | accessdate = 2007-04-14 | publisher = RxList.com}}</ref> and the effects of the drug last for over 24 hours after it has been used for 1 day or more.{{Fact|date=March 2007}} ==Indications== Lansoprazole is indicated for: *Treatment of [[ulcer]]s of the stomach and duodenum, and [[NSAID]]-induced ulcers *Treatment of [[gastroesophageal reflux disease]] (GERD) (also known as ''acid reflux disease'') *Treatment of [[Zollinger-Ellison Syndrome]] *Adjunctive treatment of ''[[Helicobacter pylori]]'' infection, alongside [[antibiotics]] ==Drug Interactions== *PPI’s reduce absorption of [[Antifungal drug|antifungals]] ([[itraconazole]] and [[ketoconazole]]) and possibly increase [[Digoxin]] in plasma *Increases plasma concentrations of [[Cilostazol]] (risk of toxicity) *Absorption of lansoprazole possibly reduced by: ** [[sucralfate]] ** [[ampicillin]] ** [[bisacodyl]] ** [[delavirdine]] ** [[fluvoxamine]] ** iron salts ** [[theophylline]] ** [[voriconazole]] ** [[aminophylline]] and [[theophylline]] ** [[astemizole]] ==Side effects== *'''Infrequent''': [[dry mouth]], [[insomnia]], [[drowsiness]], blurred [[Visual perception|vision]], [[rash]], [[pruritus]] *'''Rarely and very rarely''': [[taste]] disturbance, [[liver]] dysfunction, [[oedema|peripheral oedema]], hypersensitivity reactions (including [[bronchospasm]], urinary, [[angioedema]], [[anaphylaxis]]), [[photosensitivity]], [[fever]], [[sweating]], [[clinical depression|depression]], [[interstitial nephritis]], blood disorders (including [[leukopenia]], [[leukocytosis]], [[pancytopenia]], [[thrombocytopenia]]), [[arthralgia]], [[myalgia]], skin reactions (including [[Stevens-Johnson syndrome]], [[toxic epidermal necrolysis]], [[blister|bullous eruption]]) *'''Severe''': Gastro-intestinal disturbances (such as [[nausea]] 1.3%, [[abdominal pain]] 2.1%, [[diarrhea]] 3.8%<ref name="RxList">{{cite web | url = http://www.rxlist.com/cgi/generic/fluoxetine_cp.htm | title = Prozac Pharmacology, Pharmacokinetics, Studies, Metabolism | year = 2007 | accessdate = 2007-04-14 | publisher = RxList.com}}</ref> == Brand names == [[image:prevacid30mg.png|thumb|Prevacid 30&nbsp;mg]] The drug is sold under several brand names, including: [http://www.mosbysdrugconsult.com/DrugConsult/Top_200/Drugs/e3230.html] * '''Aprazol''' (Turkey) * '''Duogast''' (Syria) * '''Lanpro''' (India) * '''Lansox''' (Italy) * '''Lanton''' (Israel) * '''Lanzor''' (France) * '''Laprazol''' (Greece) * '''Limpidex''' (Italy) * '''Ogast''' and '''OgastORO''' (France) * '''Prevacid''' (U.S. and Canada) Prevacid is a product of [[TAP Pharmaceutical Products]]. * '''Prosogan''' and '''Prosogan FD''' (Indonesia) * '''Refluxon''' (Hungary) * '''SOLOX''' (New Zealand) * '''Takepron''' (Japan) * '''Zoton''' (Italy, Ireland, Australia, UK) Lansoprazole is also available as a [[generic drug]] in the UK, Belgium, France, Colombia, Italy and Mexico. == References == {{Reflist}} == External links == * [http://www.prevacid.com Prevacid] (manufacturer's website) * [http://www.prevakids.com Prevacid Pediatrics] (manufacturer's website) * [http://www.tap.com/prd_prev.asp#prevpac Prevpac] (manufacturer's website) {{Proton-Pump Inhibitors}} [[Category:Proton pump inhibitors]] [[Category:Benzimidazoles]] [[Category:Sulfoxides]] [[Category:Pyridines]] [[es:Lansoprazol]] [[it:Lansoprazolo]] [[hu:Lansoprazol]] [[nl:Lansoprazol]] [[pl:Lanzoprazol]] [[ru:Лансопразол]] [[tr:Lansoprazol]]