Larsen syndrome 5266918 204435712 2008-04-09T12:23:08Z Arcadian 104523 infobox {{unreferenced|date=April 2008}} {{Infobox_Disease | Name = {{PAGENAME}} | Image = | Caption = | DiseasesDB = 32807 | ICD10 = | ICD9 = | ICDO = | OMIM = 150250 | OMIM_mult = {{OMIM2|245600}} | MedlinePlus = | eMedicineSubj = | eMedicineTopic = | MeshID = }} '''Larsen Syndrome (LS)''' is a rare [[autosomal]] [[dominant]] genetic disease that occurs in about every 1 in 100,000 people. Its symptoms include [[hypermobility]], congenital dislocations, [[brachycephaly]] and [[cleft palate]]. The full descriptor of LS is '''Autosomal Dominant Larsen Syndrome'''. The condition was first described in a 1952 article by L. J. Larsen, et al. [[Image:autodominant.jpg|thumb|right|{{PAGENAME}} has an autosomal dominant pattern of [[inheritance]].]] ==Symptoms== A more complete list of symptoms includes:<br> *Multiple joint dislocations *Foot deformities *Non-tapering, cylindrical shaped fingers *Unusual facial appearance *Less commonly occurring: **Short stature **Additional skeletal abnormalities **[[Cleft palate]] **Heart defects **Hearing impairment **[[Mental retardation]] A similar syndrome, known as [[Desbuquois syndrome]], has been mapped to a different gene locus. ==See also== * [[FLNB]] ==External links== * [http://www.cedars-sinai.edu/6015.html Cedars-Sinai Entry] * [http://www.webmd.com/hw/raising_a_family/nord497.asp WebMD Abstract] {{Congenital malformations and deformations of musculoskeletal system}} {{Genetic-disorder-stub}} [[Category:Genetic disorders]] [[Category:Orthopedics]] [[Category:Pediatrics]] [[Category:Rare diseases]] [[Category:Syndromes]]