Lev's disease
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2008-06-21T21:50:39Z
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DiseasesDB = 33970 |
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ICD9 = {{ICD9|426.0}} |
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OMIM = 113900 |
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'''Lev's disease''' (or '''Lenegre-Lev syndrome''') is an acquired [[complete heart block]] due to idiopathic fibrosis and calcification of the [[electrical conduction system of the heart|electrical conduction system]] of the [[heart]]. Lev's disease is most commonly seen in the elderly, and is often described as senile degeneration of the conduction system.
One form has been associated with [[SCN5A]].<ref name="pmid10471492">{{cite journal |author=Schott JJ, Alshinawi C, Kyndt F, ''et al'' |title=Cardiac conduction defects associate with mutations in SCN5A |journal=Nat. Genet. |volume=23 |issue=1 |pages=20–1 |year=1999 |pmid=10471492 |doi=10.1038/12618}}</ref>
==History==
It was described independently by two researchers in [[1964]],<ref>Lev M. ''Anatomic basis for atrioventricular block''. Am J Med 1964;37:742-8. PMID 14237429.</ref><ref>Lenegre J. ''Etiology and pathology of bilateral bundle branch block in relation to complete heart block.'' Prog Cardiovasc Dis 1964;6:409-444. PMID 14153648.</ref> but the condition is generally called after Lev.
==Associated conditions==
[[Stokes-Adams attack]]s can be precipitated by this condition. These involve a temporary loss of consciousness due to ventricular fibrillation or asystole.
==References==
<references/>
==See also==
*[[Heart block]]
{{disease-stub}}
[[Category:Cardiac electrophysiology]]
[[pl:Choroba Leva]]