Lipid 17940 225025081 2008-07-11T14:54:29Z TimVickers 1635280 /* Lipid factor */ remove single-sentence section to talk [[Image:Common lipids lmaps.png|thumb|right|350px|Some common lipids. At the top is [[oleic acid]] and [[cholesterol]]. In the middle is a [[triglyceride]] composed of [[oleate|oleoyl]], [[stearate|stearoyl]], and [[palmitate|palmitoyl]] chains attached to a [[glycerol]] backbone. At the bottom is the common [[phospholipid]] [[phosphatidylcholine]]. ]] '''Lipids''' are broadly defined as any fat-soluble ([[Lipophilicity|lipophilic]]), naturally-occurring [[molecule]], such as fats, oils, waxes, cholesterol, sterols, fat-soluble [[vitamin]]s (such as vitamins A, D, E and K), [[monoglycerides]], [[diglycerides]], [[phospholipids]], and others. The main biological functions of lipids include energy storage, acting as structural components of [[cell membrane]]s, and participating as important [[lipid signaling|signaling molecules]]. Although the term ''lipid'' is sometimes used as a synonym for [[fat]]s, fats are a subgroup of lipids called [[triglyceride]]s and should not be confused with the term [[fatty acid]]. Lipids also encompass molecules such as fatty acids and their derivatives (including [[triglyceride|tri-]], [[diglyceride|di-]], and [[monoglyceride]]s and [[phospholipid]]s), as well as other [[sterol]]-containing [[metabolite]]s such as [[cholesterol]]. <ref>{{cite book | last = Maton | first = Anthea | authorlink = | coauthors = Jean Hopkins, Charles William McLaughlin, Susan Johnson, Maryanna Quon Warner, David LaHart, Jill D. Wright | title = Human Biology and Health | publisher = Prentice Hall | date = 1993 | location = Englewood Cliffs, New Jersey, USA | pages = | url = | doi = | id = | isbn = 0-13-981176-1}}</ref> The [[emulsion test]] is a crude method for determining the presence or absence of lipids in a given sample. Lipids are a diverse group of compounds that have many key biological functions, such as acting as structural components of cell membranes, serving as energy storage sources and participating in signaling pathways. Lipids may be broadly defined as [[Hydrophobe|hydrophobic]] or [[Amphiphile|amphiphilic]] small molecules that originate entirely or in part from two distinct types of biochemical subunits or "building blocks": [[ketone|ketoacyl]] and [[isoprene]] groups.<ref>{{cite journal |author=Fahy E, Subramaniam S, Brown HA, ''et al'' |title=A comprehensive classification system for lipids |journal=J. Lipid Res. |volume=46 |issue=5 |pages=839–61 |year=2005 |pmid=15722563 |doi= 10.1194/jlr.E400004-JLR200}}</ref> Using this approach, lipids may be divided into eight categories : fatty acyls, glycerolipids, glycerophospholipids, sphingolipids, saccharolipids and polyketides (derived from condensation of ketoacyl subunits); and sterol lipids and prenol lipids (derived from condensation of isoprene subunits). == Categories of Lipids == [[Image:Lipid examples.png|thumb|right|350px|Examples of some lipids from various categories.]] *'''Fatty acyls''' (including [[fatty acid]]s) are a diverse group of molecules synthesized by chain-elongation of an [[acetyl-CoA]] primer with [[malonyl-CoA]] or [[methylmalonyl-CoA]] groups.<ref name="Vance">{{cite book |author=Vance, Jean E.; Vance, Dennis E. |title=Biochemistry of lipids, lipoproteins and membranes |publisher=Elsevier |location=Amsterdam |year=2002 |pages= |isbn=0444511393 |oclc= |doi=}}</ref><ref name="Brown">{{cite book |author= |title=Lipodomics and Bioactive Lipids: Mass Spectrometry Based Lipid Analysis, Volume 432 (Methods in Enzymology) |publisher=Academic Press |location=Boston |year= |pages= |isbn=0123738954 |oclc= |doi=}}</ref> The fatty acyl structure represents the major lipid building block of complex lipids and therefore is one of the most fundamental categories of biological lipids. The carbon chain may be saturated or unsaturated, and may be attached to functional groups containing oxygen, halogens, nitrogen and sulfur. Examples of biologically interesting fatty acyls are the [[eicosanoid]]s which are in turn derived from arachidonic acid which include [[prostaglandin]]s, [[leukotriene]]s, and [[thromboxane]]s. Other major lipid classes in the fatty acyl category are the fatty esters and fatty amides. Fatty esters include important biochemical intermediates such as [[wax ester]]s, fatty acyl thioester [[coenzyme A]] derivatives, fatty acyl thioester ACP derivatives and fatty acyl carnitines. The fatty amides include N-acyl ethanolamines such as [[anandamide]]. *'''Glycerolipids''' are composed mainly of mono-, di- and tri-substituted glycerols,<ref>{{cite journal |author=Coleman, R.A. and Lee, D.P. |title=Enzymes of triacylglycerol synthesis and their regulation |journal=Prog. Lipid Res. |volume=43 |pages=134-176 |year=2004 }}</ref> the most well-known being the fatty acid esters of glycerol (triacylglycerols), also known as [[triglyceride]]s. these comprise the bulk of storage fat in animal tissues. Additional subclasses are represented by glycosylglycerols, which are characterized by the presence of one or more sugar residues attached to glycerol via a glycosidic linkage. Examples of structures in this category are the digalactosyldiacylglycerols found in plant membranes and seminolipid from mammalian spermatazoa. *'''Glycerophospholipids''', also referred to as [[phospholipid]]s, are ubiquitous in nature and are key components of the lipid bilayer of cells, as well as being involved in metabolism and signaling. Glycerophospholipids<ref name="Ivanova">{{cite journal |author=Ivanova PT, Milne SB, Byrne MO, Xiang Y, Brown HA |title=Glycerophospholipid identification and quantitation by electrospray ionization mass spectrometry |journal=Meth. Enzymol. |volume=432 |issue= |pages=21–57 |year=2007 |pmid=17954212 |doi=10.1016/S0076-6879(07)32002-8}}</ref> may be subdivided into distinct classes, based on the nature of the polar headgroup at the ''sn''-3 position of the glycerol backbone in eukaryotes and eubacteria or the ''sn''-1 position in the case of archaebacteria. Examples of glycerophospholipids found in [[biological membrane]]s are phosphatidylcholine (also known as PC or GPCho, and [[lecithin]]), phosphatidylethanolamine (PE or GPEtn) and phosphatidylserine (PS or GPSer). In addition to serving as a primary component of cellular membranes and binding sites for intra- and intercellular proteins, some glycerophospholipids in eukaryotic cells, such as [[phosphatidylinositol]]s and phosphatidic acids are either precursors of, or are themselves, membrane-derived second messengers. Typically one or both of these hydroxyl groups are acylated with long-chain fatty acids, but there are also alkyl-linked and 1Z-alkenyl-linked (plasmalogen) glycerophospholipids, as well as dialkylether variants in prokaryotes. *'''Sphingolipids''' are a complex family of compounds<ref name="Merrill">Merrill, A.H., Jr. and Sandhoff, K.(2002) "Sphingolipids: metabolism and cell signaling",in ''New Comprehensive Biochemistry: Biochemistry of Lipids, Lipoproteins,and Membranes'', Vance, D.E. and Vance, J.E., eds. Elsevier Science, NY. Ch. 14.</ref> that share a common structural feature, a sphingoid base backbone that is synthesized ''de novo'' from serine and a long-chain fatty acyl CoA, then converted into [[ceramide]]s, phosphosphingolipids, glycosphingolipids and other species. The major sphingoid base of mammals is commonly referred to as [[sphingosine]]. Ceramides (N-acyl-sphingoid bases) are a major subclass of sphingoid base derivatives with an amide-linked fatty acid. The fatty acids are typically saturated or mono-unsaturated with chain lengths from 14 to 26 carbon atoms. The major phosphosphingolipids of mammals are sphingomyelins (ceramide phosphocholines), whereas insects contain mainly ceramide phosphoethanolamines and fungi have phytoceramidephosphoinositols and mannose containing headgroups. The Glycosphingolipids are a diverse family of molecules composed of one or more sugar residues linked via a glycosidic bond to the sphingoid base. Examples of these are the simple and complex glycosphingolipids such as [[cerebroside]]s and [[ganglioside]]s. *'''Sterol lipids''', such as [[cholesterol]] and its derivatives are an important component of membrane lipids,<ref>{{cite journal |author=Bach, D., and Wachtel, E. |title=Phospholipid/cholesterol model membranes: formation of cholesterol crystallites. |journal=Biochim Biophys Acta. |volume=1610 |pages=187-197 |year=2003 }}</ref> along with the glycerophospholipids and sphingomyelins. The [[steroid]]s, which also contain the same fused four-ring core structure, have different biological roles as hormones and signaling molecules. The C18 steroids include the [[estrogen]] family whereas the C19 steroids comprise the [[androgen]]s such as [[testosterone]] and [[androsterone]]. The C21 subclass includes the progestogens as well as the [[glucocorticoid]]s and mineralocorticoids. The secosteroids, comprising various forms of [[vitamin D]], are characterized by cleavage of the B ring of the core structure. Other examples of [[sterol]]s are the [[bile acid]]s and their conjugates,<ref>{{cite journal |author=Russell, D.W. |title=The enzymes, regulation, and genetics of bile acid synthesis. |journal=Annu.Rev Biochem |volume=72 |pages=137-174 |year=2003 | doi = 10.1146/annurev.biochem.72.121801.161712 <!--Retrieved from CrossRef by DOI bot-->}}</ref> which in mammals are oxidized derivatives of cholesterol and are synthesized in the liver. [[Image:Kdo2 lipidA.png|thumb|right|300px|'''Figure 2:''' Structure of the saccharolipid Kdo<sub>2</sub>-Lipid A. Glucosamine residues in blue, Kdo residues in red, acyl chains in black and phosphate groups in green.]] *'''Prenol lipids''' are synthesized from the 5-carbon precursors isopentenyl diphosphate and dimethylallyl diphosphate that are produced mainly via the [[mevalonic acid]] (MVA) pathway.<ref>{{cite journal |author=Kuzuyama, T. and Seto, H. |title=Diversity of the biosynthesis of the isoprene units. |journal=Nat.Prod Rep. |volume=20 |pages=171-183 |year=2003 | doi = 10.1039/b109860h <!--Retrieved from CrossRef by DOI bot-->}}</ref> The simple isoprenoids (linear alcohols, diphosphates, etc.) are formed by the successive addition of C5 units, and are classified according to number of these [[terpene]] units. Structures containing greater than 40 carbons are known as polyterpenes. [[Carotenoid]]s are important simple isoprenoids that function as anti-oxidants and as precursors of [[vitamin A]]. Another biologically important class of molecules is exemplified by the quinones and hydroquinones, which contain an isoprenoid tail attached to a quinonoid core of non-isoprenoid origin. [[Vitamin E]] and [[vitamin K]], as well as the ubiquinones, are examples of this class. Bacteria synthesize polyprenols (called bactoprenols) in which the terminal isoprenoid unit attached to oxygen remains unsaturated, whereas in animal polyprenols (dolichols) the terminal isoprenoid is reduced. *'''Saccharolipids''' describe compounds in which fatty acids are linked directly to a sugar backbone, forming structures that are compatible with membrane bilayers. In the saccharolipids, a sugar substitutes for the glycerol backbone that is present in glycerolipids and glycerophospholipids. The most familiar saccharolipids are the acylated [[glucosamine]] precursors of the Lipid A component of the [[lipopolysaccharide]]s in Gram-negative bacteria. Typical lipid A molecules are disaccharides of glucosamine, which are derivatized with as many as seven fatty-acyl chains. The minimal lipopolysaccharide required for growth in ''E. coli'' is Kdo<sub>2</sub>-Lipid A, a hexa-acylated disaccharide of glucosamine that is glycosylated with two 3-deoxy-D-manno-octulosonic acid (Kdo) residues.<ref>{{cite journal |author=Raetz, C. R., Garrett, T. A., Reynolds, C. M., ''et al'' |title=Kdo2-Lipid A of Escherichia coli, a defined endotoxin that activates macrophages via TLR-4 |journal=J. Lipid Res. |volume=47 |pages=1097-1111 |year=2006 |pmid=16479018 |doi= 10.1194/jlr.M600027-JLR200}}</ref> *'''Polyketides''' are synthesized by polymerization of [[acetyl]] and propionyl subunits by classic enzymes as well as iterative and multimodular enzymes that share mechanistic features with the fatty acid synthases. They comprise a very large number of secondary metabolites and natural products from animal, plant, bacterial, fungal and marine sources, and have great structural diversity.<ref>{{cite journal |author=Walsh, C.T. |title=Polyketide and nonribosomal peptide antibiotics: modularity and versatility |journal=Science. |volume=303 |pages=1805-1810 |year=2004 | doi = 10.1126/science.1094318 <!--Retrieved from CrossRef by DOI bot-->}}</ref> Many [[polyketide]]s are cyclic molecules whose backbones are often further modified by glycosylation, methylation, hydroxylation, oxidation, and/or other processes. Many commonly used anti-microbial, anti-parasitic, and anti-cancer agents are polyketides or polyketide derivatives, such as [[erythromycin]]s, tetracylines, [[avermectin]]s, and antitumor [[epothilone]]s. == Biological Functions == === Membranes === The [[glycerophospholipids]] are the main structural component of [[biological membranes]], such as the cellular [[plasma membrane]] and the intracellular membranes of [[organelles]]. In animal cells the plasma membrane physically separates the intracellular components from the extracellular environment. All eukaryotic cells are compartmentalized into membrane-bound organelles which carry out different functions. These glycerophospholipids are amphipathic molecules that contain a glycerol core linked to two fatty acid-derived "tails" by ester or, more rarely, [[ether]] linkages and to one "head" group by a [[phosphate]] ester linkage. While glycerophospholipids are the major component of biological membranes, other non-glyceride lipid components such as [[sphingomyelin]] and [[sterol]]s (mainly [[cholesterol]] in animal cell membranes) are also found in biological membranes. In plants and algae, the galactosyldiacylglycerols,<ref name="Heinz">Heinz, E.(1996) Plant glycolipids: structure, isolation and analysis. in ''Advances in Lipid Methodology - 3'', pp. 211-332 (ed. W.W. Christie, Oily Press, Dundee) </ref> and sulfoquinovosyldiacylglycerol,<ref>{{cite journal |author=Hölzl, G. and Dörmann, P. |title=Structure and function of glycoglycerolipids in plants and bacteria |journal=Prog. Lipid Res.|volume=46|pages=225-243 |year=2007 }}</ref> which lack a phosphate group, are important components of membranes of chloroplasts and related organelles and are the most abundant lipids in photosynthetic tissues, including those of higher plants, algae and certain bacteria. [[Image:Phospholipids aqueous solution structures.svg|thumb|250px|Self-organization of [[phospholipid]]s: a spherical [[liposome]], a [[micelle]] and a [[lipid bilayer]].]] A biological membrane is a form of lipid bilayer, as is a [[liposome]]. The formation of lipid bilayers is an energetically-preferred process when the [[glycerophospholipids]] described above are in an aqueous environment. In an aqueous system, the polar heads of lipids orientate towards the polar, aqueous environment, while the hydrophobic tails minimise their contact with water. The lipophilic tails of lipids (<font color="#0000AA">U</font>) tend to cluster together, forming a [[lipid bilayer]] (1) or a [[micelle]] (2). Other aggregations are also observed and form part of the polymorphism of [[amphiphile]] (lipid) behaviour. The polar heads (<font color="#AA0000">P</font>) face the aqueous environment, curving away from the water. [[Phase behaviour]] is a complicated area within biophysics and is the subject of current academic research. Micelles and bilayers form in the polar medium by a process known as the [[hydrophobic effect]].<ref>{{cite journal |author=Wiggins PM |title=Role of water in some biological processes |journal=Microbiol. Rev. |volume=54 |issue=4 |pages=432-49 |year=1990 |pmid=2087221 |url=http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=372788&blobtype=pdf}}</ref> When dissolving a lipophilic or amphiphilic substance in a polar environment, the polar molecules (i.e. water in an aqueous solution) become more ordered around the dissolved lipophilic substance, since the polar molecules cannot form [[hydrogen bond]]s to the lipophilic areas of the [[amphiphile]]. So in an aqueous environment the water molecules form an ordered "[[clathrate]]" cage around the dissolved lipophilic molecule.<ref>{{cite journal |author=Raschke TM, Levitt M |title=Nonpolar solutes enhance water structure within hydration shells while reducing interactions between them |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue=19 |pages=6777-82 |year=2005 |pmid=15867152 |url=http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=15867152 | doi = 10.1073/pnas.0500225102 <!--Retrieved from CrossRef by DOI bot-->}}</ref> === Energy storage and metabolism === Triacylglycerols, stored in adipose tissue, are a major form of energy storage in animals. Animals use triglycerides for energy storage because of its high caloric content (9 kcal/g), whereas plants, which do not require energy for movement, can afford to store food for energy in a less compact but more easily accessible form, such as starch (carbohydrate). Triglycerides and phospholipids are broken down into free fatty acids by the action of lipases. [[Beta oxidation]] is the process by which fatty acids, in the form of acyl-CoA molecules, are broken down in the mitochondria and/or in peroxisomes to generate acetyl-CoA. The acetyl CoA is then ultimately converted into [[Adenosine triphosphate|ATP]], CO2, and H2O using the [[citric acid cycle]] and the [[electron transport chain]]. Conversely, fatty acid biosynthesis ([[Lipogenesis]]) takes place in the cytoplasm, using acetyl-CoA (derived from carbohydrates, amino acids or fatty acids) as the precursor<ref name="Stryer">Berg, J.M., Tymoczko, J.L., Stryer, L.(2006) Biochemistry, Freeman, New York.5th ed. ISBN 0716787245</ref>. The fatty acids may be subsequently converted to triacylglycerols that are packaged in [[lipoproteins]] (VLDL's) and secreted from the liver. === Signaling === In recent years, evidence has emerged showing that [[lipid signaling]] is a vital part of the [[cell signaling]].<ref>{{cite journal |author=Wang X |title=Lipid signaling |journal=Curr. Opin. Plant Biol. |volume=7 |issue=3 |pages=329-36 |year=2004 |pmid=15134755 | doi = 10.1016/j.pbi.2004.03.012 <!--Retrieved from CrossRef by DOI bot-->}}</ref> Lipid signaling may occur via activation of GPCR's or nuclear receptors, and members of several different lipid categories have been identified as signaling molecules and cellular messengers.<ref>{{cite journal |author=Eyster,K.M. |title=The membrane and lipids as integral participants in signal transduction |journal=Adv. Physiol. Edu. |volume=31|pages=5-16 |year=2007 }}</ref> These include [[sphingosine-1-phosphate]], a sphingolipid derived from ceramide that is a potent messenger molecule involved in regulating calcium mobilization, cell growth, apoptosis; [[diacylglycerol]](DAG) and the [[phosphatidylinositol]] phosphates (PIPs), involved in calcium-mediated activation of [[protein kinase C]]; the [[prostaglandins]], arachidonic acid -derived fatty acids involved in inflammation and immunity; the steroid hormones such as [[estrogen]], [[testosterone]] and [[cortisol]], which modulate a host of functions such as reproduction, metabolism and blood pressure; and the oxysterols such as 25-hydroxy-cholesterol that are [[Liver X receptor]] (LXR) agonists. === Other functions === The "fat-soluble" vitamins (A, D, E and K) which are isoprene-based lipids are essential nutrients stored in the liver and fatty tissues. These have a diverse range of functions discussed elsewhere. Acyl-carnitines are involved in the transport and metabolism of fatty acids in and out of mitochondria, where they undergo beta oxidation. Polyprenols and their phosphorylated derivatives also play important transport roles, in this case the transport of oligosaccharides across membranes. Polyprenol phosphate sugars and polyprenol diphosphate sugars function in extra-cytoplasmic glycosylation reactions, in extra-cellular polysaccharide biosynthesis (for instance peptidoglycan polymerization in bacteria), and in eukaryotic protein N-glycosylation.<ref>{{cite journal |author=Helenius, A., Aebi, M. |title=Intracellular functions of N-linked glycans |journal=Science |volume=291 |pages=2364-2369 |year=2001 |pmid=11269317 | doi = 10.1126/science.291.5512.2364 <!--Retrieved from CrossRef by DOI bot-->}}</ref> Cardiolipins are a subclass of glycerophospholipids containing four acyl chains and three glycerol groups that are particularly abundant in the inner mitochondrial membrane. They are believed to activate enzymes involved with oxidative phosphorylation.<ref>{{cite journal |author=Hoch, FL |title=Cardiolipins and biomembrane function |journal=Biochim. Biophys. Acta. |volume=1113 |issue=1 |pages=71-133 |year=1992 |pmid=10206472 }}</ref> ==Nutrition and health== Lipids play diverse and important roles in nutrition and health.<ref name="Spiller">Spiller, G.A. ed., (2006), Handbook of Lipids in Human Nutrition,Boca Raton: CRC Press. </ref> Many lipids are absolutely essential for life. However, there is also considerable awareness that abnormal levels of certain lipids, particularly cholesterol (in hypercholesterolemia) and trans fatty acids, are [[risk factor]]s for [[heart disease]] amongst others. Humans have a requirement for certain essential fatty acids, such as [[linoleic acid]] (an omega-6 fatty acid) and [[alpha-linolenic acid]] (an omega-3 fatty acid) in the diet because they cannot be synthesized from simple precursors in the diet. Both of these fatty acids are 18-carbon polyunsaturated fatty acids differing in the number and position of the double bonds. Most vegetable oils are rich in linoleic acid (safflower, sunflower, and corn oils). Alpha-linolenic acid is found in the green leaves of plants, and in selected seeds, nuts and legumes (flax, canola, walnuts and soy). Fish oils are particularly rich in the longer-chain omega-6 fatty acids [[eicosapentaenoic acid]] (EPA) and [[docosahexaenoic acid]] (DHA). Most of the lipid found in food is in the form of triacylglycerols, cholesterol and phospholipids. Most of the saturated fatty acids (as triacylglycerols) in the diet are incorporated into adipose tissue stores, because the absence of double bonds allows a higher energy yield per carbon than is obtained from oxidation of unsaturated fatty acids. The longer chain fatty acids are incorporated into cell membranes as phospholipids regardless of degree of saturation. Since dietary fatty acids are exchanged with membrane fatty acids, dietary fat composition is reflected in membrane lipid composition. Thus dietary fatty acids can influence cell function through effects on membrane properties. Dietary fat provides an average energy intake which is approximately twice that of carbohydrate or protein. A minimum amount of dietary fat is necessary to facilitate absorption of fat-soluble vitamins (A, D, E and K) and carotenoids. A minimal amount of body fat is also necessary to provide insulation that prevents heat loss and protects vital organs from shock due to ordinary activities. High fat intake contributes to increased risk of obesity, diabetes and atherosclerosis. [[Atherosclerosis]] is the primary cause of coronary and cardiovascular diseases and is primary due to the buildup of plaque on the inside walls of arteries. Plaque is made up of cholesterol-rich low density lipoproteins (LDL), macrophages, smooth muscle cells, platelets, and other substances. In North America and most other western countries, atherosclerosis is the leading cause of illness and death, almost doubling the number of deaths from cancers. Despite significant medical advances, coronary artery disease and atherosclerotic stroke are responsible for more deaths than all other causes combined.A substantial amount of scientific evidence supports the impact of dietary fatty acids on cardiovascular health. Saturated fats have a profound hypercholesterolemic (increase blood cholesterol levels) effect and tend to increase plasma LDL. They are found predominantly in animal products (butter, cheese and meat) but coconut oil and palm oil are common vegetable sources. Intake of monounsaturated fats in oils such as olive oil is thought to be preferable to consumption of polyunsaturated fats in oils such as corn oil because the monounsaturated fats apparently do not lower high-density-lipoprotein (HDL) cholesterol levels.<ref>{{cite journal |author=Dreon, D.M., Vranizan, K.M., Krauss, R.M., Austin, M.A., Wood, P.D.|title=The effects of polyunsaturated fat vs monounsaturated fat on plasma lipoproteins |journal=JAMA |volume=263 |issue=18 |pages=2462-6 |year=1990 |pmid=2329634 | doi = 10.1001/jama.263.18.2462 <!--Retrieved from CrossRef by DOI bot-->}}</ref> Keeping cholesterol in the normal range not only helps prevent heart attacks and strokes but may also prevent the progression of atherosclerosis. "[[Statins]]" are a class of drugs that lowers the level of cholesterol in the blood by inhibiting the enzyme [[HMG-CoA reductase]]. This is a key enzyme involved in the biosynthesis of cholesterol in the liver. ==References== {{reflist}} ==See also== {{commonscat|Lipids}} * [[Biochemistry]] * [[Essential fatty acid]] * [[Lipid microdomain]] * [[Protein-lipid interaction]] * [[Lipid signaling]] * [[PG]], a lipid factor essential for [[trimerization]]. * [[Saturation (chemistry)]] ==External links== {{portal|Food}} '''Introductory''' * [http://www.lipidlibrary.co.uk/ Lipid Library] - General reference on lipid chemistry and biochemistry * [http://www.lipidomics.net/ European Lipidomics Initiative] - European research resource for lipid biochemistry. * [http://www.cyberlipid.org/ Cyberlipid.org] - Resources and history for lipids. * [http://www.scienceaid.co.uk/biology/fundamentals/lipids.html Science aid: Lipids] - Resource for students * [http://www.fos.su.se/~sasha/Lipid_membranes.html Molecular Computer Simulations] - Modeling of Lipid Membranes * [http://www.biochemweb.org/lipids_membranes.shtml Lipids, Membranes and Vesicle Trafficking] - The Virtual Library of Biochemistry and Cell Biology '''Classification''' * [http://www.lipidmaps.org/ LIPID MAPS] - LIPID Metabolites And Pathways Strategy '''Nomenclature''' * [http://www.chem.qmul.ac.uk/iupac/lipid/ IUPAC nomenclature of lipids] * [http://www.chem.qmul.ac.uk/iupac/class/lipid.html IUPAC glossary entry for the lipid class of molecules] '''Databases''' * [http://www.lipidmaps.org/ LIPID MAPS] - Comprehensive lipid and lipid-associated gene/protein databases. * [http://lipidbank.jp/ LipidBank] - Japanese database of lipids and related properties, spectral data and references. * [http://www.lipidat.ul.ie// LIPIDAT] - Database composed mainly of phospholipids and associated thermodynamic data. '''General''' * [http://www.apollolipids.org/ ApolloLipids] - Provides dyslipidemia and cardiovascular disease prevention and treatment information as well as continuing medical education programs * [http://www.lipid.org/ National Lipid Association] - Professional medical education organization for health care professionals who seek to prevent morbidity and mortality stemming from dyslipidemias and other cholesterol-related disorders. {{metabolism}} {{Food chemistry}} {{Lipids}} {{Lipoproteins}} {{Phospholipids}} {{Sphingolipids}} [[Category:Lipids|*]] {{Link FA|de}} [[ar:ليبيدات]] [[bg:Липид]] [[ca:Lípid]] [[cs:Lipidy]] [[da:Lipid]] [[de:Lipide]] [[es:Lípido]] [[eo:Lipido]] [[eu:Lipido]] [[fa:لیپید]] [[fr:Lipide]] [[ga:Lipidí]] [[ko:지질]] [[hr:Lipidi]] [[id:Lipid]] [[is:Fita]] [[it:Lipidi]] [[he:ליפיד]] [[pam:Lipid]] [[lv:Lipīdi]] [[lb:Lipid]] [[lt:Lipidai]] [[mk:Липид]] [[nl:Lipide]] [[ja:脂質]] [[no:Lipid]] [[pl:Lipidy]] [[pt:Lípido]] [[ro:Lipide]] [[ru:Липиды]] [[simple:Lipid]] [[sk:Lipid]] [[sl:Lipid]] [[sr:Липиди]] [[sh:Lipidi]] [[su:Lipid]] [[fi:Lipidi]] [[sv:Lipid]] [[th:ลิพิด]] [[te:కొవ్వు పదార్ధాలు]] [[vi:Lipit]] [[tr:Lipit]] [[uk:Ліпіди]] [[zh:脂類]]