List of recombinant proteins
3016399
220201000
2008-06-18T19:12:07Z
167.206.144.30
/* Human recombinants that largely replaced animal or harvested from human types */
Since human recombinants have replaced the animal version in human therapeutics, the prefix of "rh" for "human recombinant" appears less and less in the literature
==Human recombinants that largely replaced animal or harvested from human types==
*[[Growth hormone|Human growth hormone]] (rhGH) Humatrope from [[Eli Lilly and Company|Lilly]] and Serostim from [[Serono]] replaced [[cadaver]] harvested human growth hormone
*[[Insulin|Human insulin]] (rhI) Humulin from [[Eli Lilly and Company|Lilly]] and Novolin from [[Novo Nordisk]] among others; largely replaced bovine and porcine insulin for human therapy. Some prefer to continue using the animal-sourced preparations, as there is some evidence that synthetic insulin varieties are more likely to induce [[Diabetic hypoglycemia#Hypoglycemic_unawareness|hypoglycemia unawareness]]. Remaining manufacturers of highly-purified animal-sourced insulin include the U.K.'s Wockhardt Ltd. (headquartered in India), Poland's Polfa Tarchomin S.A., Argentina's Laboratorios Beta S.A., and China's Wanbang Biopharma Co.
*[[Follicle-stimulating hormone]] FSH replaced [[Serono]]'s [[Pergonal]] which was previously isolated from post-menopausal female urine
*[[Factor VIII]] Kogenate from [[Bayer]] replaced [[blood]] harvested factor VIII
==Human recombinants with recombination as only source==
*[[Erythropoietin]] (EPO) Epogen from [[Amgen]]
*[[Granulocyte colony-stimulating factor]] (G-CSF) filgrastim sold as Neupogen from [[Amgen]]; pegfilgrastim sold as Neulasta
*[[alpha-glactosidase A]] Fabrazyme by [[Genzyme]]
*[[alpha-L-iduronidase]] (rhIDU; laronidase) Aldurazyme by [[BioMarin Pharmaceutical]] and [[Genzyme]]
*[[N-acetylgalactosamine-4-sulfatase]] (rhASB; galsulfase) Naglazyme (TM) by [[BioMarin Pharmaceutical]]
*[[DNAse]] Pulmozyme by [[Genentech]]
*[[Tissue plasminogen activator]] (TPA) Activase by [[Genentech]]
*[[Glucocerebrosidase]] Ceredase by [[Genzyme]]
*[[Interferon]] (IF) Interferon-beta-1a as Avonex from Biogen Idec; Rebif from [[Serono]]; Interferon beta-1b as Betaseron from [[Schering]]
*[[Insulin-like growth factor 1]] (IGF-1)
==Animal recombinants==
*[[Bovine somatotropin]] (bST)
*[[Porcine somatotropin]] (pST)
*[[Bovine Chymosin]]
==Viral recombinants==
*Envelope protein of the [[hepatitis B]] virus marketed as Engerix-B by [[SmithKline Beecham]]
[[Category:Proteins| ]]
[[Category:Peptide hormones]]