Liver disease 865271 225271451 2008-07-12T20:31:00Z 24.141.23.116 /* Symptoms of a diseased liver */ {{Infobox_Disease | Name = {{PAGENAME}} | Image = | Caption = | DiseasesDB = | ICD10 = | ICD9 = | ICDO = | OMIM = | MedlinePlus = | eMedicineSubj = | eMedicineTopic = | MeshID = D008107 | }} '''Liver disease''' is a broad term describing any number of [[disease]]s affecting the [[liver]]. Many are accompanied by [[jaundice]] caused by increased levels of [[bilirubin]] in the system. The bilirubin results from the breakup of the [[hemoglobin]] of dead [[red blood cell]]s; normally, the liver removes bilirubin from the blood and excretes it through bile. * [[Hepatitis]], inflammation of the liver, caused mainly by various [[virus]]es but also by some poisons, autoimmunity or hereditary conditions. * [[Cirrhosis]] is the formation of fibrous tissue in the liver, replacing dead liver cells. The death of the liver cells can for example be caused by viral hepatitis, [[alcoholism]] or contact with other liver-toxic chemicals. * [[Haemochromatosis]], a hereditary disease causing the accumulation of [[iron]] in the body, eventually leading to liver damage. * [[Cancer]] of the liver (primary [[hepatocellular carcinoma]] or [[cholangiocarcinoma]] and metastatic cancers, usually from other parts of the [[gastrointestinal tract]]). * [[Wilson's disease]], a [[hereditary disease]] which causes the body to retain [[copper]]. * [[Primary sclerosing cholangitis]], an [[inflammation|inflammatory]] disease of the [[bile duct]], likely autoimmune in nature. * [[Primary biliary cirrhosis]], autoimmune disease of small bile ducts. * [[Budd-Chiari syndrome]], obstruction of the hepatic vein. * [[Gilbert's syndrome]], a genetic disorder of [[bilirubin]] metabolism, found in about 5% of the population. * [[Glycogen storage disease type II]],The build-up of glycogen causes progressive muscle weakness (myopathy) throughout the body and affects various body tissues, particularly in the heart, skeletal muscles, liver and nervous system. There are also many pediatric liver disease, including [[biliary atresia]], [[alpha-1 antitrypsin deficiency]], [[alagille syndrome]], and [[progressive familial intrahepatic cholestasis]], to name but a few. A number of [[liver function tests]] are available to test the proper function of the liver. These test for the presence of enzymes in blood that are normally most abundant in liver tissue, metabolites or products. ====Symptoms of a diseased liver==== The external signs include a coated tongue, bad breath, skin rashes, itchy skin, excessive sweating, offensive body odour, dark circles under the eyes, red swollen and itchy eyes, acne [[rosacea]], brownish spots and blemishes on the skin, flushed facial appearance or excessive facial blood vessels.<ref>[http://www.liverdoctor.com/index.php?page=symptoms Dr Sandra Cabot - The Liver Doctor]</ref> Other symptoms include jaundice, dark urine, pale stool, bone loss, easy bleeding, itching, small, spider-like blood vessels visible in the skin, enlarged spleen, fluid in the abdominal cavity, chills, pain from the biliary tract or pancrea, and an enlarged gallbladder.<ref>[http://www.umm.edu/liver/common.htm University of Maryland - Symptoms of Liver Disease]</ref> The symptoms related to liver dysfunction include both physical signs and a variety of symptoms related to digestive problems, blood sugar problems, immune disorders, abnormal absorption of fats, and metabolism problems.<ref>[http://www.liverdoctor.com/index.php?page=symptoms Dr Sandra Cabot - The Liver Doctor]</ref> The malabsorption of fats may lead to symptoms that include indigestion, reflux, hemorhoids, gall stones, intolerance to fatty foods, intolerance to alcohol, nausea and vomiting attacks, abdominal bloating, and constipation. Nervous system disorders include depression, mood changes, especially anger and irritability, poor concentration and "[[foggy brain]]", overheating of the body, especially the face and torso, and recurrent headaches (including migraine) associated with nausea. The blood sugar problems include a craving for sugar, hypoglycaemia and unstable blood sugar levels, and the onset of diabetes (Type 2). Abnormalities in the level of fats in the blood stream include elevated LDL cholesterol, reduced HDL cholesterol, elevated triglycerides, clogged arteries leading to high blood pressure heart attacks and strokes, build up of fat in other body organs (fatty degeneration of organs), lumps of fat in the skin (lipomas and other fatty tumors), excessive weight gain (which may lead to obesity), inability to lose weight even while dieting, sluggish metabolism, protuberant abdomen (pot belly), cellulite, fatty liver, and a roll of fat around the upper abdomen (liver roll).<ref>[http://www.liverdoctor.com/index.php?page=symptoms Dr Sandra Cabot - The Liver Doctor]</ref> ==References== {{reflist}} {{Digestive system diseases}} {{Congenital malformations and deformations of digestive system}} [[Category:Digestive system]] [[Category:Hepatology]] [[it:Epatopatia]]