Lucey-Driscoll syndrome 5237839 214251117 2008-05-22T19:15:34Z Arcadian 104523 nav {{unreferenced|date=January 2008}} {{Infobox_Disease | Name = {{PAGENAME}} | Image = | Caption = | DiseasesDB = 32677 | ICD10 = | ICD9 = {{ICD9|774.30}} | ICDO = | OMIM = | MedlinePlus = | eMedicineSubj = | eMedicineTopic = | MeshID = | }} '''Lucey-Driscoll syndrome''' is an [[autosomal recessive]] metabolic disorder affecting enzymes involved in [[bilirubin]] metabolism. It is one of several disorders classified as a transient familial neonatal unconjugated [[hyperbilirubinemia]]. ==Cause== The common cause is congenital, but it can also be caused by maternal [[steroids]] passed on through [[breast milk]] to the [[newborn]]. It is different from breast milk jaundice (breast-fed infants have higher bilirubine levels than formula-fed ones). ==Genetics== [[Image:autorecessive.jpg|thumb|right|{{PAGENAME}} has an autosomal recessive pattern of inheritance.]] A defect in the [[UGT1A1]]-gene, also linked to [[Crigler-Najjar syndrome]] and [[Gilbert's syndrome]], is responsible for the congenital form of Lucey-Driscoll syndrome. ==External links== * {{OMIM|237900}} - transient familial neonatal hyperbilirubinemia, breast feeding jaundice included *{{eMedicine|med|1066}} - Unconjugated hyperbilirubinemia {{Heme metabolism disorders}} [[Category:Hepatology]] [[Category:Genetic disorders]] [[Category:Autosomal recessive disorders]] [[Category:Syndromes]] {{disease-stub}}