Lucey-Driscoll syndrome
5237839
214251117
2008-05-22T19:15:34Z
Arcadian
104523
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{{unreferenced|date=January 2008}}
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ICD9 = {{ICD9|774.30}} |
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'''Lucey-Driscoll syndrome''' is an [[autosomal recessive]] metabolic disorder affecting enzymes involved in [[bilirubin]] metabolism.
It is one of several disorders classified as a transient familial neonatal unconjugated [[hyperbilirubinemia]].
==Cause==
The common cause is congenital, but it can also be caused by maternal [[steroids]] passed on through [[breast milk]] to the [[newborn]]. It is different from breast milk jaundice (breast-fed infants have higher bilirubine levels than formula-fed ones).
==Genetics==
[[Image:autorecessive.jpg|thumb|right|{{PAGENAME}} has an autosomal recessive pattern of inheritance.]]
A defect in the [[UGT1A1]]-gene, also linked to [[Crigler-Najjar syndrome]] and [[Gilbert's syndrome]], is responsible for the congenital form of Lucey-Driscoll syndrome.
==External links==
* {{OMIM|237900}} - transient familial neonatal hyperbilirubinemia, breast feeding jaundice included
*{{eMedicine|med|1066}} - Unconjugated hyperbilirubinemia
{{Heme metabolism disorders}}
[[Category:Hepatology]]
[[Category:Genetic disorders]]
[[Category:Autosomal recessive disorders]]
[[Category:Syndromes]]
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