Lymecycline 4116120 174910036 2007-11-30T20:40:56Z 77.100.24.54 /* Formulation */ {{drugbox | |width=198 |IUPAC_name = 2-(amino-hydroxy-methylidene)- 7-chloro-4-dimethylamino- 6,10,11,12a- tetrahydroxy-6- methyl- 4,4a,5,5a-tetrahydrotetracene-1 ,3,12-trione |CAS_number = 992-21-2 | ATC_prefix=J01 | ATC_suffix=AA04 | PubChem=23649 | DrugBank=APRD00565 | C=22 | H=23 | C=1 | N=2 | O=8 |molecular_weight = 478.879 |bioavailability = 100% (oral) |metabolism = ? |elimination_half-life = ? |excretion = [[renal]] |pregnancy_category = ? ([[Australia|Aust]]) |legal_status = Schedule 4 ([[Australia|Aust]]) |routes_of_administration = oral }} '''Lymecycline''' is a [[tetracycline antibiotics|tetracycline]] [[broad-spectrum antibiotic]] marketed by the pharmeceutical company Galderma[http://www.galderma.com]. It is approximately 5000 times more [[soluble]] than [[tetracycline]] base and is unique amongst tetracyclines in that it is [[Absorption (chemistry)|absorbed]] by the "active transport" process across the intestinal wall, making use of the same fast and efficient mechanism by which [[carbohydrate]]s are absorbed.{{ref|NZdrugdata}} The greater absorption of Lymecycline allows for lower dosages to be used; the standard dose of 408 mg is equivalent to 300 mg tetracycline base, and in its action to 500 mg tetracycline hydrochloride. Lymecycline, unlike tetracycline hydrochloride, is soluble at all [[physiological]] [[pH]] values. ==History== Lymecycline was released onto the pharmaceutical market in [[1963]]. ==Indications== Lymecycline, like other Tetracyclines, is used to treat a range of infections (see [[Tetracycline antibiotics]] group). Its better absorption profile makes it preferable to tetracycline for moderately severe [[Acne vulgaris|acne]] and typically prescribed for 8 weeks at a time, but alternatives should be sought if no improvement occurs by 3 months.{{ref|BNF}} ==Dosage== The standard dose is 408mg (one capsule) twelve hourly by mouth. In particularly severe infections this dose may be increased to 1.224-1.632mg (three or four capsules) daily. The 408mg once daily dosage for acne aids good [[Compliance (medicine)|drug compliance]]. [[Image:Tetralysal.jpg|thumb|250px|Lymecycline capsules]] == Formulation == Capsules containing 408mg of Lymecycline (brand name '''Tetralysal 300). ==References== #{{note|NZdrugdata}} [[New Zealand]] [http://www.medsafe.govt.nz/profs/Datasheet/t/Tetralysalcap.htm Datasheet] August 2003 #{{note|BNF}} [[British National Formulary]] ''45'' March 2003 ==See also== [[Timeline of antibiotics]] {{TetracyclineAntiBiotics}} [[Category:Tetracycline antibiotics]] [[es:Limeciclina]] [[hu:Limeciklin]] [[th:ไลมีซัยคลิน]]