Lymecycline
4116120
174910036
2007-11-30T20:40:56Z
77.100.24.54
/* Formulation */
{{drugbox |
|width=198
|IUPAC_name = 2-(amino-hydroxy-methylidene)- 7-chloro-4-dimethylamino- 6,10,11,12a- tetrahydroxy-6-
methyl- 4,4a,5,5a-tetrahydrotetracene-1 ,3,12-trione
|CAS_number = 992-21-2
| ATC_prefix=J01
| ATC_suffix=AA04
| PubChem=23649
| DrugBank=APRD00565
| C=22 | H=23 | C=1 | N=2 | O=8
|molecular_weight = 478.879
|bioavailability = 100% (oral)
|metabolism = ?
|elimination_half-life = ?
|excretion = [[renal]]
|pregnancy_category = ? ([[Australia|Aust]])
|legal_status = Schedule 4 ([[Australia|Aust]])
|routes_of_administration = oral
}}
'''Lymecycline''' is a [[tetracycline antibiotics|tetracycline]] [[broad-spectrum antibiotic]] marketed by the pharmeceutical company Galderma[http://www.galderma.com]. It is approximately 5000 times more [[soluble]] than [[tetracycline]] base and is unique amongst tetracyclines in that it is [[Absorption (chemistry)|absorbed]] by the "active transport" process across the intestinal wall, making use of the same fast and efficient mechanism by which [[carbohydrate]]s are absorbed.{{ref|NZdrugdata}}
The greater absorption of Lymecycline allows for lower dosages to be used; the standard dose of 408 mg is equivalent to 300 mg tetracycline base, and in its action to 500 mg tetracycline hydrochloride. Lymecycline, unlike tetracycline hydrochloride, is soluble at all [[physiological]] [[pH]] values.
==History==
Lymecycline was released onto the pharmaceutical market in [[1963]].
==Indications==
Lymecycline, like other Tetracyclines, is used to treat a range of infections (see [[Tetracycline antibiotics]] group). Its better absorption profile makes it preferable to tetracycline for moderately severe [[Acne vulgaris|acne]] and typically prescribed for 8 weeks at a time, but alternatives should be sought if no improvement occurs by 3 months.{{ref|BNF}}
==Dosage==
The standard dose is 408mg (one capsule) twelve hourly by mouth. In particularly severe infections this dose may be increased to 1.224-1.632mg (three or four capsules) daily.
The 408mg once daily dosage for acne aids good [[Compliance (medicine)|drug compliance]].
[[Image:Tetralysal.jpg|thumb|250px|Lymecycline capsules]]
== Formulation ==
Capsules containing 408mg of Lymecycline (brand name '''Tetralysal 300).
==References==
#{{note|NZdrugdata}} [[New Zealand]] [http://www.medsafe.govt.nz/profs/Datasheet/t/Tetralysalcap.htm Datasheet] August 2003
#{{note|BNF}} [[British National Formulary]] ''45'' March 2003
==See also==
[[Timeline of antibiotics]]
{{TetracyclineAntiBiotics}}
[[Category:Tetracycline antibiotics]]
[[es:Limeciclina]]
[[hu:Limeciklin]]
[[th:ไลมีซัยคลิน]]