Lyssavirus
780034
211737744
2008-05-11T21:46:55Z
Gaius Cornelius
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{{otheruses4|the rabiform virus|the [[hemorrhagic fever]]-causing Lassa virus|Lassa fever}}
{{Taxobox
<!-- Color parameter is not needed -- automatically assigned -->
| name = ''Lyssavirus
| virus_group = v
| ordo = ''[[Mononegavirales]]''
| familia = ''[[Rhabdoviridae]]''
| genus = '''''Lyssavirus'''''
| type_species = ''[[Rabies virus]]''
| subdivision_ranks = Species
| subdivision = ''[[Aravan virus]]''<br>
''[[Australian bat lyssavirus]]''<br>
''[[Duvenhage virus]]''<br>
''[[European bat lyssavirus 1]]''<br>
''[[European bat lyssavirus 2]]''<br>
''[[Irkut virus]]''<br>
''[[Khujand virus]]''<br>
''[[Lagos bat virus]]''<br>
''[[Mokola virus]]''<br>
''[[West Caucasian bat virus]]''
}}
'''Lyssavirus''' (from a word meaning ''frenzy'') is a genus of [[virus]]es belonging to the family ''[[Rhabdoviridae]]'', in the order ''[[Mononegavirales]]''.
This group of [[RNA virus]]es includes the ''[[Rabies virus]]'' traditionally associated with the disease.
Viruses typically have either helical or cubic symmetry. Lyssaviruses have helical symmetry, so their infectious particles are approximately cylindrical in shape. This is typical of plant-infecting viruses. Human-infecting viruses more commonly have cubic symmetry and take shapes approximating [[regular polyhedron|regular polyhedra]].
== Lyssavirus Genome ==
Lyssavirus [[genome]]s consist of a negative-sense, single-stranded [[RNA]] molecule that codes for five different viral proteins, which include [[polymerase]] L, matrix [[protein]] M, [[phosphoprotein]] P, [[nucleoprotein]] N, and [[glycoprotein]] G.
== Lyssavirus structure ==
The structure consists of a spiked outer [[envelope (biology)|envelope]], a middle region consisting of protein M, and an inner ribonucleocapsid complex region, consisting of the genome associated with other proteins.
== Lyssavirus Genotypes ==
Based on recent evidence, Lyssaviruses are categorized into seven major [[genotype]]s. In addition, there have been four genotypes recently discovered, and these are West Caucasian Bat virus, Aravan Virus, Khujand virus, and Irkut virus. The major genotypes include [[Rabies virus]] (genotype 1), [[Lagos bat virus]] (2), [[Mokola virus]] (3), Duvenhage virus (4), European Bat lyssaviruses 1 and 2 (5 and 6), and [[Australian bat lyssavirus]] (7). Based on biological properties of the [[virus]]es, these genotypes are further subdivided into phylogroups 1 and 2. Phylogroup 1 includes genotypes 1, 4, 5, 6, and 7, while phylogroup 2 includes genotypes 2 and 3. The nucleocapsid region of lyssavirus is fairly highly conserved from genotype to genotype across both phylogroups; however, experimental data has shown that lyssavirus strains used in vaccinations are only from the first genotype of the first phylogroup.
== Animal Vectors for Lyssaviruses ==
Genotype 1, classic [[rabies]], is prevalent throughout the world and can be carried by domesticated or wild animals. The other genotypes (types 2 through 7) have much less diversity in carriers. Only select [[host (biology)|host]]s can carry each of the genotypes. Also, these other genotypes are particular only to a specific geographic area.
Bats are known to be an animal [[vector (biology)|vector]] for all but one of the seven genotypes, the one being Mokola virus.
== References ==
{{Cite web
| title = World Health Organization Expert Consultation on Rabies
| url = http://www.who.int/rabies/ExpertConsultationOnRabies.pdf
| accessdate = 2007-03-04 }}
==External links==
* [http://patric.vbi.vt.edu/organism/overview.php?organismId=8 Lyssavirus] (from [http://patric.vbi.vt.edu/ PATRIC] the PathoSystems Resource Integration Center, a [http://www3.niaid.nih.gov/ NIAID] Bioinformatics Resource Center)
*[http://www.cdc.gov/ncidod/EID/vol9no3/02-0252.htm Arai YT, Kuzmin IV, Kameoka Y, Botvinkin AD. New lyssavirus genotype from the lesser mouse-eared bat (Myotis blythi), Kyrghyzstan. Emerg Infect Dis 2003 Mar.]
*[http://www.cdc.gov/ncidod/EID/vol9no12/03-0374.htm Botvinkin AD, Poleschuk EM, Kuzmin IV, Borisoa TI, Gazaryan SV, Yager P, et al. Novel lyssaviruses isolated from bats in Russia. Emerg Infect Dis 2003 Dec.]
[[Category:Mononegavirales]]
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[[fr:Lyssavirus]]