Macrocytosis
2570033
181929156
2008-01-03T19:13:40Z
Jfdwolff
46555
Reverted edits by [[Special:Contributions/Linzhoo2u|Linzhoo2u]] ([[User talk:Linzhoo2u|talk]]) to last version by Sbharris
{{Infobox_Disease |
Name = Macrocytosis |
Image = |
Caption = |
DiseasesDB = 7688 |
ICD10 = {{ICD10|D|75|8|d|70}} |
ICD9 = {{ICD9|289.89}} |
ICDO = |
OMIM = |
MedlinePlus = |
eMedicineSubj = med |
eMedicineTopic = 1381 |
MeshName = |
MeshNumber = |
}}
'''Macrocytosis''' is the enlargement of [[red blood cell]]s with near-constant [[haemoglobin]] concentration, and is defined by a [[mean corpuscular volume]] (MCV) of greater than 100 femtolitres (the precise criterion varies between laboratories).
== Causes ==
Most commonly (especially when the increase in size is mild, and just above normal range) the etiology is [[bone marrow]] [[dysplasia]] primary to [[alcohol abuse]]. Other causes may include:
* [[Megaloblastosis]] ([[Vitamin B12]] or [[folate]] deficiency; or DNA synthesis-inbiting drugs)
* [[hypothyroidism]]
* [[reticulocytosis]] (commonly from hemolysis or a recent history of blood loss).
* [[liver disease]]
* [[myeloproliferative disease]]
== Complications ==
No complications arise from macrocytosis itself and a [[prognosis]] will be determined from its [[aetiology]].
{{pathology-stub}}
[[Category:Hematology]]
[[Category:Clinical pathology]]