Macrocytosis 2570033 181929156 2008-01-03T19:13:40Z Jfdwolff 46555 Reverted edits by [[Special:Contributions/Linzhoo2u|Linzhoo2u]] ([[User talk:Linzhoo2u|talk]]) to last version by Sbharris {{Infobox_Disease | Name = Macrocytosis | Image = | Caption = | DiseasesDB = 7688 | ICD10 = {{ICD10|D|75|8|d|70}} | ICD9 = {{ICD9|289.89}} | ICDO = | OMIM = | MedlinePlus = | eMedicineSubj = med | eMedicineTopic = 1381 | MeshName = | MeshNumber = | }} '''Macrocytosis''' is the enlargement of [[red blood cell]]s with near-constant [[haemoglobin]] concentration, and is defined by a [[mean corpuscular volume]] (MCV) of greater than 100 femtolitres (the precise criterion varies between laboratories). == Causes == Most commonly (especially when the increase in size is mild, and just above normal range) the etiology is [[bone marrow]] [[dysplasia]] primary to [[alcohol abuse]]. Other causes may include: * [[Megaloblastosis]] ([[Vitamin B12]] or [[folate]] deficiency; or DNA synthesis-inbiting drugs) * [[hypothyroidism]] * [[reticulocytosis]] (commonly from hemolysis or a recent history of blood loss). * [[liver disease]] * [[myeloproliferative disease]] == Complications == No complications arise from macrocytosis itself and a [[prognosis]] will be determined from its [[aetiology]]. {{pathology-stub}} [[Category:Hematology]] [[Category:Clinical pathology]]