Macroglossia 1965394 216645873 2008-06-02T16:03:01Z AnjaManix 5964318 {{Infobox_Disease | Name = {{PAGENAME}} | Image = | Caption = | DiseasesDB = 7689 | ICD10 = {{ICD10|Q|38|2|q|38}} | ICD9 = {{ICD9|529.8}} | ICDO = | OMIM = 153630 | MedlinePlus = | eMedicineSubj = ent | eMedicineTopic = 746 | MeshID = D008260 | }} '''Macroglossia''' is the medical term for unusual enlargement ([[Organ hypertrophy|hypertrophy]]) of the [[tongue]]. Severe enlargement of the tongue can cause cosmetic and functional difficulties including in speaking, eating, swallowing and sleeping. Macroglossia is common in primary and myeloma-related [[amyloidosis]]. Amyloidosis is an accumulation of insoluble proteins in tissues that impedes normal function. (Merck Manual 17th Ed.) Macroglossia is also a clinical feature in [[congenital hypothyroidism]], rare genetic syndromes such as [[Beckwith-Wiedemann syndrome]] and [[immunodeficiency, centromere instability and facial anomalies syndrome]], [[acromegaly]] and [[Hurler syndrome]]. ==External links== *[http://www.bcm.edu/oto/grand/52892.html Grand Rounds Site] {{med-sign-stub}} {{Congenital malformations and deformations of digestive system}} [[de:Makroglossie]] [[it:Macroglossia]] [[pl:Makroglosja]]