Male-limited precocious puberty
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2008-07-08T01:05:25Z
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| OMIM = 176410
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'''Male-limited precocious puberty''' (also known as '''familial sexual precocity''' and '''gonadotropin-independent testotoxicosis''')<ref name=omim>{{OMIM|176410}}</ref> is a form of [[gonadotropin]]-independent [[precocious puberty]] in which boys experience early onset and progression of [[puberty]].<ref>{{cite journal | author=Traggiai C, Stanhope R | title=Disorders of pubertal development | journal=Best Pract Res Clin Obstet Gynaecol | year=2003 | pages=41–56 | volume=17 | issue=1 | pmid=12758225 | doi=10.1053/ybeog.2003.0360}}</ref> Signs of puberty can develop as early as an age of 1 year.
The spinal length in boys may be short due to a rapid advance in epiphyseal maturation. It is an [[autosomal dominant]]<ref name=omim/> condition with a [[mutation]] of the [[LH receptor]]. Treatment is with drugs that suppress gonadal [[steroidogenesis]], such as [[cyproterone acetate]], [[ketoconazole]] or [[spironolactone]] and [[testolactone]].<ref>{{cite journal | author=Reiter EO, Norjavaara E | title=Testotoxicosis: current viewpoint | journal=Pediatr Endocrinol Rev | year=2005 | pages=77–86 | volume=3 | issue=2 | pmid=16361981}}</ref>
[[Image:autodominant.jpg|thumb|right|{{PAGENAME}} has an autosomal dominant pattern of [[inheritance]].]]
==References==
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[[Category:Genetic disorders]]
[[Category:Congenital disorders]]
[[Category:Rare diseases]]
[[Category:Diseases]]
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