Male-limited precocious puberty 3725531 224258281 2008-07-08T01:05:25Z DOI bot 6652755 Citation maintenance. Formatted: pages. Initiated by [[User:Rcej|Rcej]]. You can [[WP:DOI|use this bot]] yourself! Please [[User:DOI_bot/bugs|report any bugs]]. {{Infobox_Disease | Name = {{PAGENAME}} | Image = | Caption = | DiseasesDB = | ICD10 = | ICD9 = | ICDO = | OMIM = 176410 | MedlinePlus = | eMedicineSubj = | eMedicineTopic = | MeshID = }} '''Male-limited precocious puberty''' (also known as '''familial sexual precocity''' and '''gonadotropin-independent testotoxicosis''')<ref name=omim>{{OMIM|176410}}</ref> is a form of [[gonadotropin]]-independent [[precocious puberty]] in which boys experience early onset and progression of [[puberty]].<ref>{{cite journal | author=Traggiai C, Stanhope R | title=Disorders of pubertal development | journal=Best Pract Res Clin Obstet Gynaecol | year=2003 | pages=41–56 | volume=17 | issue=1 | pmid=12758225 | doi=10.1053/ybeog.2003.0360}}</ref> Signs of puberty can develop as early as an age of 1 year. The spinal length in boys may be short due to a rapid advance in epiphyseal maturation. It is an [[autosomal dominant]]<ref name=omim/> condition with a [[mutation]] of the [[LH receptor]]. Treatment is with drugs that suppress gonadal [[steroidogenesis]], such as [[cyproterone acetate]], [[ketoconazole]] or [[spironolactone]] and [[testolactone]].<ref>{{cite journal | author=Reiter EO, Norjavaara E | title=Testotoxicosis: current viewpoint | journal=Pediatr Endocrinol Rev | year=2005 | pages=77–86 | volume=3 | issue=2 | pmid=16361981}}</ref> [[Image:autodominant.jpg|thumb|right|{{PAGENAME}} has an autosomal dominant pattern of [[inheritance]].]] ==References== {{reflist}} [[Category:Genetic disorders]] [[Category:Congenital disorders]] [[Category:Rare diseases]] [[Category:Diseases]] {{genetic-disorder-stub}}