Malonate 570556 224663772 2008-07-09T21:37:03Z TimVickers 1635280 ref [[Image:Malonate.png|thumb|Chemical structure of the malonate ion.]] The '''malonate''' or '''propanedioate''' [[ion]] is [[Carbon|C]][[Hydrogen|H]]<sub>2</sub>(C[[Oxygen|O]]O)<sub>2</sub><sup>2&minus;</sup> ([[malonic acid]] minus two [[hydrogen ion]]s). Malonate [[chemical compound|compounds]] include [[salt]]s and [[ester]]s of malonic acid, such as: * [[Diethyl malonate]], (C<sub>2</sub>H<sub>5</sub>)<sub>2</sub>(C<sub>3</sub>H<sub>2</sub>O<sub>4</sub>) * [[Dimethyl malonate]], (CH<sub>3</sub>)<sub>2</sub>(C<sub>3</sub>H<sub>2</sub>O<sub>4</sub>) * [[Disodium malonate]], [[Sodium|Na]]<sub>2</sub>(C<sub>3</sub>H<sub>2</sub>O<sub>4</sub>) Malonate is a [[enzyme inhibition|inhibitor]] of [[cellular respiration]], because it binds to the [[active site]] of the [[succinate dehydrogenase]] in the [[citric acid cycle]] but does not react, thereby competing with [[succinate]]. For the [[oxidative phosphorylation]] reaction, Malonate is an inhibitor for [[complex II]] which, again, contains [[succinate dehydrogenase]].<ref>{{cite journal |author=Dervartanian DV, Veeger C. |title=Studies on succinate dehydrogenase. I. Spectral properties of the purified enzyme and formation of enzyme-competitive inhibitor complexes |journal=Biochim. Biophys. Acta |volume=92 |issue= |pages=233–47 |year=1964 |month=November |pmid=14249115}}</ref> ==See also== * [[Malonate ester synthesis]] ==References== {{reflist}} [[Category:Carboxylate anions]] [[Category:Malonates|*]] {{organic-compound-stub}}