Malonate
570556
224663772
2008-07-09T21:37:03Z
TimVickers
1635280
ref
[[Image:Malonate.png|thumb|Chemical structure of the malonate ion.]]
The '''malonate''' or '''propanedioate''' [[ion]] is [[Carbon|C]][[Hydrogen|H]]<sub>2</sub>(C[[Oxygen|O]]O)<sub>2</sub><sup>2−</sup> ([[malonic acid]] minus two [[hydrogen ion]]s). Malonate [[chemical compound|compounds]] include [[salt]]s and [[ester]]s of malonic acid, such as:
* [[Diethyl malonate]], (C<sub>2</sub>H<sub>5</sub>)<sub>2</sub>(C<sub>3</sub>H<sub>2</sub>O<sub>4</sub>)
* [[Dimethyl malonate]], (CH<sub>3</sub>)<sub>2</sub>(C<sub>3</sub>H<sub>2</sub>O<sub>4</sub>)
* [[Disodium malonate]], [[Sodium|Na]]<sub>2</sub>(C<sub>3</sub>H<sub>2</sub>O<sub>4</sub>)
Malonate is a [[enzyme inhibition|inhibitor]] of [[cellular respiration]], because it binds to the [[active site]] of the [[succinate dehydrogenase]] in the [[citric acid cycle]] but does not react, thereby competing with [[succinate]].
For the [[oxidative phosphorylation]] reaction, Malonate is an inhibitor for [[complex II]] which, again, contains [[succinate dehydrogenase]].<ref>{{cite journal |author=Dervartanian DV, Veeger C. |title=Studies on succinate dehydrogenase. I. Spectral properties of the purified enzyme and formation of enzyme-competitive inhibitor complexes |journal=Biochim. Biophys. Acta |volume=92 |issue= |pages=233–47 |year=1964 |month=November |pmid=14249115}}</ref>
==See also==
* [[Malonate ester synthesis]]
==References==
{{reflist}}
[[Category:Carboxylate anions]]
[[Category:Malonates|*]]
{{organic-compound-stub}}