Mangafodipir 5438189 207592532 2008-04-23T12:48:18Z MOwhOw 6920901 {{drugbox | IUPAC_name = | image = Mangafodipir 3D sticks.png | CAS_number = 119797-12-5 | ATC_prefix = V08 | ATC_suffix = CA05 | PubChem = 107732 | DrugBank = | C=22|H=28|Mn=1|N=4|O=14|P=2 | molecular_weight = 689.362 g/mol | bioavailability = NA | protein_bound = 27% (manganese)<br>Negligible (DPDP) | metabolism = | elimination_half-life = 20 minutes (manganese)<br>50 minutes (DPDP) | excretion = [[Kidney|Renal]] and fecal (manganese)<br>Renal (DPDP) | pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --> | pregnancy_US = <!-- A / B / C / D / X --> | pregnancy_category= Not to be used | legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 --> | legal_CA = <!-- / Schedule I, II, III, IV, V, VI, VII, VIII --> | legal_UK = <!-- GSL / P / POM / CD / Class A, B, C --> | legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V --> | legal_status = | routes_of_administration = [[Intravenous therapy|Intravenous infusion]] }} '''Mangafodipir''' (sold under the brand name '''Teslascan''' as mangafodipir trisodium) is a [[contrast agent]] delivered [[intravenous]]ly to enhance contrast in [[magnetic resonance imaging]] (MRI) of the liver. It has two parts, [[paramagnetism|paramagnetic]] manganese (II) ions and the [[chelation|chelating]] agent fodipir (dipyridoxyl diphosphate, DPDP). Normal liver tissue absorbs the manganese more than abnormal or cancerous tissue. The manganese shortens the [[Relaxation (NMR)|longitudinal relaxation]] time (T1), making the normal tissue appear brighter in MRIs. This enhanced contrast allows lesions to be more easily identified. ==References== *[http://www.teslascan.com Teslascan.com] *[http://www.nlm.nih.gov/medlineplus/druginfo/uspdi/203456.html MedlinePlus data sheet] *[http://www.medsafe.govt.nz/Profs/Datasheet/t/Teslascaninj.htm Medsafe data sheet] {{drug-stub}} [[Category:Manganese compounds]] [[Category:Radiocontrast agents]]