Mangafodipir
5438189
207592532
2008-04-23T12:48:18Z
MOwhOw
6920901
{{drugbox
| IUPAC_name =
| image = Mangafodipir 3D sticks.png
| CAS_number = 119797-12-5
| ATC_prefix = V08
| ATC_suffix = CA05
| PubChem = 107732
| DrugBank =
| C=22|H=28|Mn=1|N=4|O=14|P=2
| molecular_weight = 689.362 g/mol
| bioavailability = NA
| protein_bound = 27% (manganese)<br>Negligible (DPDP)
| metabolism =
| elimination_half-life = 20 minutes (manganese)<br>50 minutes (DPDP)
| excretion = [[Kidney|Renal]] and fecal (manganese)<br>Renal (DPDP)
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
| pregnancy_US = <!-- A / B / C / D / X -->
| pregnancy_category= Not to be used
| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 -->
| legal_CA = <!-- / Schedule I, II, III, IV, V, VI, VII, VIII -->
| legal_UK = <!-- GSL / P / POM / CD / Class A, B, C -->
| legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V -->
| legal_status =
| routes_of_administration = [[Intravenous therapy|Intravenous infusion]]
}}
'''Mangafodipir''' (sold under the brand name '''Teslascan''' as mangafodipir trisodium) is a [[contrast agent]] delivered [[intravenous]]ly to enhance contrast in [[magnetic resonance imaging]] (MRI) of the liver. It has two parts, [[paramagnetism|paramagnetic]] manganese (II) ions and the [[chelation|chelating]] agent fodipir (dipyridoxyl diphosphate, DPDP). Normal liver tissue absorbs the manganese more than abnormal or cancerous tissue. The manganese shortens the [[Relaxation (NMR)|longitudinal relaxation]] time (T1), making the normal tissue appear brighter in MRIs. This enhanced contrast allows lesions to be more easily identified.
==References==
*[http://www.teslascan.com Teslascan.com]
*[http://www.nlm.nih.gov/medlineplus/druginfo/uspdi/203456.html MedlinePlus data sheet]
*[http://www.medsafe.govt.nz/Profs/Datasheet/t/Teslascaninj.htm Medsafe data sheet]
{{drug-stub}}
[[Category:Manganese compounds]]
[[Category:Radiocontrast agents]]