Manganism 1587653 211449185 2008-05-10T12:02:24Z McM.bot 3453363 robot Adding: [[pl:Zatrucie manganem]] {{Infobox_Disease | Name = {{PAGENAME}} | Image = | Caption = | DiseasesDB = | ICD10 = {{ICD10|T|57|2|t|51}} | ICD9 = {{ICD9|985.2}} | ICDO = | OMIM = | MedlinePlus = | eMedicineSubj = | eMedicineTopic = | MeshID = D020149 }} '''Manganism''' or '''manganese [[poisoning]]''' is a [[toxic]] condition resulting from chronic exposure to [[manganese]] and first identified in 1837 by [[James Couper]]. In initial stages of manganism, neurological symptoms consist of reduced response speed, irritability, mood changes, and compulsive behaviors.<ref name="pmid16629164">{{cite journal |author=Roth JA |title=Homeostatic and toxic mechanisms regulating manganese uptake, retention, and elimination |journal=Biol. Res. |volume=39 |issue=1 |pages=45–57 |year=2006 |pmid=16629164 |doi=}}</ref> Upon protracted exposure symptoms are more prominent and resemble those of [[idiopathic]] [[Parkinson's disease]], which it is often misdiagnosed as, although there are particular differences in both the symptoms (nature of tremors, for example), response to drugs such as [[L-DOPA|Levadopa]], and affected portion of the [[basal ganglia]]. Symptoms are also similar to [[Motor neurone disease|Lou Gehrig's disease]] and [[multiple sclerosis]]. Manganism has become an active issue in [[occupational safety and health|workplace safety]] as it has been the subject of numerous [[product liability]] lawsuits against manufacturers of [[arc welding]] supplies. In these lawsuits, welders have accused the manufacturers of failing to provide adequate warning that their products could cause welding fumes to contain dangerously high manganese concentrations that could lead welders to develop manganism. ==References== {{reflist}} ==External references== *[http://www.bio.unipd.it/~zatta/metals/mangan.htm Lucchini et al., "Metals and Neurodegeneration"] - Research paper on [[heavy metals]] poisoning *[http://journalsonline.tandf.co.uk/openurl.asp?genre=article&issn=1040-8444&volume=33&issue=1&spage=61 Antonini., "Health Effects of Welding"] - Critical review including manganese discussion from National Institute of Occupational Safety and Health ([[NIOSH]]) *[http://www.ibew.org/articles/03journal/030708/p8.htm Welding and Manganese Poisoning] - Safety Corner column in IBEW Journal regarding manganese and welding. *[http://www.aws.org/duke_study/index.html AWS Study on Welding and Exposure to Manganese] - Report of an independent study commissioned by the American Welding Society *[http://www.welding-rod-litigation.com/ Welding Fume Product Liability] - Viewpoint of plaintiffs on welding rod litigation *[http://www.weldinginfonetwork.com/ Welding Rod Litigation Information Network] - Viewpoint of defense on welding rod litigation [[Category:Neurological disorders]] [[Category:Manganese]] {{Poisoning and toxicity}} [[ko:망간중독]] [[nl:Manganisme]] [[pl:Zatrucie manganem]]