Marginal zone
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Caption = Transverse section of a portion of the [[spleen]]. |
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The '''marginal zone''' is the region at the interface between the non-lymphoid [[red pulp]] and the [[lymphoid]] [[white-pulp]] of the [[spleen]]. (Some sources consider it to be the part of red pulp which borders on the white pulp, while other sources consider it to be neither red pulp nor white pulp.)
==Composition and markers==
It is composed of cells derived primarily from the [[myeloid]] compartment of [[bone marrow]] differentiation. At least three distinct [[cellular markers]] can be used to identify cells of the marginal zone, MOMA-1, ERTR-9 and MARCO.
==Function==
The major role of marginal zone is to trap particulate [[antigen]] from the [[circulation]] and present the antigen to the lymphocytes of the spleen.
Experiments have shown that inert [[latex]] [[beads]] as well as live bacteria such as [[Escherichia coli]] and [[Listeria monocytogenes]] are trapped by the marginal zone. However, only immunogenic substances, ie. [[bacteria]], are trafficked to the T and B cell zones of the white-pulp and are efficiently presented to elicit an immune response.
==Lymphocytes==
Marginal zone [[lymphocytes]] are a type of [[B cell]] ("MZ B cell") created there, capable of binding [[IgM]]-antigen complexes. They are notable for their ability to serve several different roles in the [[immune system]].
==Pathology==
It is associated with three different kinds of [[lymphoma]]:
* [[Splenic marginal zone lymphoma]]
* Extranodal marginal zone B cell lymphoma ([[MALT lymphoma]], or "mucosa-associated lymphoid tissue")
* Nodal marginal zone B cell lymphoma (NMZL)
==See also==
* [[Humoral immunity]]
==External links==
* [http://arjournals.annualreviews.org/doi/abs/10.1146/annurev.immunol.23.021704.115728;jsessionid=iUDdX9W5UAng?cookieSet=1&journalCode=immunol Annual Review of Immunology]
* [http://www.biomedcentral.com/1471-2172/6/8 BioMedCentral]
* [http://www.lymphomation.org/type-mz.htm Marginal zone lymphomas]
* [http://www.jem.org/cgi/content/abstract/198/12/1923 JEM]
* {{cite journal | author = Kraal G | title = Cells in the marginal zone of the spleen. | journal = Int Rev Cytol | volume = 132 | issue = | pages = 31–74 | year = | pmid = 1555921}}
* {{cite journal | author = Kumararatne D, MacLennan I | title = Cells of the marginal zone of the spleen are lymphocytes derived from recirculating precursors. | journal = Eur J Immunol | volume = 11 | issue = 11 | pages = 865–9 | year = 1981 | pmid = 6976895 | doi = 10.1002/eji.1830111104}}
* {{eMedicineDictionary|Marginal+zone}}
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{{Lymphatic system}}