Max Perutz
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{{Infobox_Scientist
|name = Max Ferdinand Perutz
| image = Replace this image male.svg
| imagesize = 180px
|caption = Max Perutz
|birth_date = [[May 19]] [[1914]]
|birth_place = [[Vienna]], [[Austria]]
|nationality = [[Austria]]
|death_date = {{death date and age|2002|2|6|1914|5|19 }}
|death_place = [[Cambridge]], [[England]]
|field = [[Molecular biology]], [[Crystallography]]
|work_institution = [[University of Cambridge]]
|alma_mater = [[University of Cambridge]]
|doctoral_advisor = [[J.D. Bernal]]
|doctoral_students = [[James D. Watson]] [[Image:Nobel prize medal.svg|20px]]<br />[[Francis Crick]] [[Image:Nobel prize medal.svg|20px]]
|known_for = [[Heme]]-containing [[protein]]s
|prizes = [[Image:Nobel prize medal.svg|20px]] [[Nobel Prize for Chemistry]] (1962)
}}
'''Max Ferdinand Perutz''', [[Order of Merit (Commonwealth)|OM]] ([[May 19]] [[1914]], [[Vienna]], [[Austria]] – [[February 6]] [[2002]], [[Cambridge]], [[United Kingdom|UK]]) was an [[Austria]]n-[[United Kingdom|British]] [[molecular biologist]], who was awarded the [[Nobel Prize for Chemistry]] in 1962, shared with [[John Kendrew]] for their studies of the structures of hemoglobin and globular proteins. At Cambridge he supervised the PhD work of [[Francis Crick]] and [[James Watson]] in the [[Cavendish Laboratory]] as they determined the structure of [[DNA]] in 1953.
== The scientist ==
In 1936, after doing a first university degree in Austria, Perutz became a research student at the [[University of Cambridge]]'s [[Cavendish Laboratory]], in a [[crystallography]] research group under the direction of [[J.D. Bernal]].
Perutz was affiliated with Cambridge's [[Peterhouse]] College from his 1936 [[matriculation]] until his death. He was an Honorary Fellow from 1962 to 2002, and was seen at least weekly in the College's halls until just before his death. He took a keen interest in the Junior Members, and was a regular and popular speaker at the Kelvin Club, the College's scientific society. Perutz's contributions to molecular biology in Cambridge are documented in ''The History of the University of Cambridge: Volume 4 (1870 to 1990)'' published by the Cambridge University Press in 1992.
During [[World War II]], Perutz was part of [[Project Habakkuk]], a secret project investigating the recently invented mixture of ice and woodpulp known as [[pykrete]], in the hope of using it to build an [[aircraft carrier]]. He carried out early experiments on pykrete in a secret location underneath [[Smithfield, London|Smithfield Meat Market]] in the [[City of London]].<ref>
{{cite journal
| last = Gratzer
| first = Walter
| title = Max Perutz (1914–2002)
| journal = Current Biology
| volume = 12
| issue = 5
| pages = R152–R154
| date = 2002-03-05
| url = http://download.current-biology.com/pdfs/0960-9822/PIIS0960982202007273.pdf
| doi = 10.1016/S0960-9822(02)00727-3
| accessdate = 2008-01-12
}}</ref><ref>
{{cite journal
| last = Ramaseshan
| first = S
| title = Max Perutz (1914–2002)
| journal = Current Science
| volume = 82
| pages = 586–590
| date = 2002-03-10
| publisher = Indian Academy of Sciences
| issn = 0011-3891
| url = http://hdl.handle.net/2289/728
| accessdate = 2008-01-12
| doi = 10.1016/S0960-9822(02)00727-3
}}</ref><ref>
{{cite journal
| last = Collins
| first = Paul
| title = The Floating Island
| journal = Cabinet Magazine
| issue = 7
| date = 2002
| url = http://www.cabinetmagazine.org/issues/7/floatingisland.php
| accessdate = 2008-01-12
| doi = 10.1016/S0960-9822(02)00727-3
| volume = 12
| pages = R152
}}</ref>
Perutz established the [[Medical Research Council (UK)|MRC Laboratory of Molecular Biology]], [[Cambridge, England]] in 1962 and was its chairman until 1979. He remained active in research to the end of his life.
In 1953, Perutz showed that the diffracted [[X-ray]]s from [[protein]] crystals could be phased by comparing the patterns from crystals of the protein with and without heavy atoms attached. In 1959, he employed this method to determine the molecular structure of the protein [[hemoglobin]], which transports [[oxygen]] in the blood. This work resulting in his sharing with [[John Kendrew]] the 1962 [[Nobel Prize for Chemistry]].
[[Robin Perutz]], the son of Max and Gisela Perutz, is a professor of chemistry at the [[University of York]] in [[England]]. Their daughter Vivien has edited a selection of Max's letters for publication by the Cold Spring Harbor Laboratory Press.
=== DNA structure and Rosalind Franklin ===
During the early 1950s, Perutz supervised [[James D. Watson]] and [[Francis Crick]] while they were determining the structure of [[deoxyribonucleic acid]] (DNA). Watson and Crick made use of unpublished [[X-ray diffraction]] images taken by [[Rosalind Franklin]], shown at meetings and shared with them by [[Maurice Wilkins]], and of Franklin's preliminary account of her detailed analysis of the X-ray images included in an unpublished 1952 progress report for the [[King's College]] laboratory of Sir [[John Randall]]. Randall and others eventually criticized the manner in which Perutz gave a copy of this report to Watson and Crick.
It is debatable whether Watson and Crick should have been granted access to Franklin's results without her knowledge or permission, and before she had a chance to publish a detailed analysis of the content of her unpublished progress report. It is also not clear how important the content of that report had been for Watson and Crick's modeling. In an effort to clarify this issue, Perutz later published the report, arguing that it included nothing that Franklin had not said in a talk she gave in late 1951 and that Watson attended. Perutz also added that the report was addressed to an MRC committee created in order to "establish contact between the different groups of people working for the Council". Randall's and Perutz's labs were both funded by the MRC.
== The author ==
In his later years, Perutz was a regular reviewer/essayist for ''[[The New York Review of Books]]'' on biomedical subjects. Many of these essays are reprinted in his 1998 book ''I wish I had made you angry earlier''.<ref>[http://www.nature.com/nsmb/journal/v9/n4/full/nsb0402-245.html Max Ferdinand Perutz OM FRS - Nature Structural & Molecular Biology<!-- Bot generated title -->]</ref> Perutz's flair for writing was a late development. His relative [[Leo Perutz]], a distinguished writer, told Max when he was a boy that he would never be a writer. Thus Max highly cherished his having been awarded the [[Lewis Thomas Prize|Lewis Thomas Prize for Writing about Science]] in 1997.
==The scientist-citizen==
Within days after September 11, 2001, Perutz wrote to British Prime Minister Tony Blair, appealing to him not to respond with military force: "I am alarmed by the American cries for vengeance and concerned that President Bush's retaliation will lead to the death of thousands more innocent people, driving us into a world of escalating terror and counter-terror. I do hope that you can use your restraining influence to prevent this happening."<ref>Max Perutz and the Secret of Life, By Georgina Ferry. 352 pp., illustrated. Cold Spring Harbor, NY, Cold Spring Harbor Laboratory Press, 2008 ISBN 978-0-87969-785-3.</ref>
== References ==
{{reflist}}
== External links ==
{{wikiquote}}
*Fersht, Alan R., 2002, "[http://www.nature.com/nsmb/journal/v9/n4/full/nsb0402-245.html Max Ferdinand Perutz OM FRS,]" ''Nature Structural Biology 9'': 245-46.
* [http://www2.mrc-lmb.cam.ac.uk/Max_Perutz.html By his colleagues] at the MRC Laboratory of Molecular Biology.
**[http://physicsweb.org/article/news/6/2/4 PhysicsWeb.]
* [http://www.nobel.se/chemistry/laureates/1962/perutz-bio.html Nobel website biography.]
* [http://www.vega.org.uk/series/facetoface/perutz/index.php Online video interview with Max Perutz,] provided by the Vega Science Trust. (~40 mins.)
{{Nobel Prize in Chemistry Laureates 1951-1975}}
{{Persondata<!-- Metadata: see [[Wikipedia:Persondata]] -->
|NAME= Perutz, Max Ferdinand
|ALTERNATIVE NAMES=
|SHORT DESCRIPTION= [[Molecular biology]], [[Crystallography]]
|DATE OF BIRTH= [[May 19]] [[1914]]
|PLACE OF BIRTH= [[Vienna]], [[Austria]]
|DATE OF DEATH= 2002-2-6
|PLACE OF DEATH= [[Cambridge]], [[England]]
}}
{{DEFAULTSORT:Perutz, Max}}
[[Category:1914 births]]
[[Category:2002 deaths]]
[[Category:Alumni of Peterhouse, Cambridge]]
[[Category:Austrian Jews]]
[[Category:Austrian biologists]]
[[Category:Biophysicists]]
[[Category:British Jews]]
[[Category:British biologists]]
[[Category:Fellows of Darwin College, Cambridge]]
[[Category:Jewish scientists]]
[[Category:Members of the Order of Merit]]
[[Category:Members of the Pontifical Academy of Sciences]]
[[Category:Molecular biologists]]
[[Category:Nobel laureates in Chemistry]]
[[Category:People from Vienna]]
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