Michelin tire baby syndrome 4832809 201350943 2008-03-27T16:22:52Z SYSS Mouse 74615 Reverted 1 edit by [[Special:Contributions/204.131.166.50|204.131.166.50]] identified as [[WP:VAND|vandalism]] to last revision by [[User:Tiddly Tom|Tiddly Tom]]. using [[WP:TWINKLE|TW]] '''Michelin Tire Baby Syndrome''', also known as congenital diffuse [[lipomatosis]], is characterized by multiple, symmetric, circumferential skin creases, or bands, on the forearms, lower legs, and often the neck that are present at birth. The creases disappear later in life. They are reminiscent of these of the mascot of the tire manufacturer, [[Michelin]], hence the name of the syndrome. Associated abnormalities vary and may include facial dysmorphism, upslanting palpebral fissures, [[hypertelorism]], [[cleft palate]], genital anomalies, mild developmental delay, [[ureterocele]], smooth muscle hamartoma, nevus lipomatosus, [[Laron syndrome]] (dwarfism with high growth hormone and low [[somatomedin]] activity), and other defects. It was originally described by Ross in 1969. Twenty cases of this [[hamartomatous]] disorder have been reported. ==References== # Ross CM: Generalized folded skin with an underlying lipomatous nevus: "The Michelin tire baby." Arch Dermatol 1969;100:320 # Schnur RE, Herzberg AJ, Spinner N, et al: Variability in the Michelin tire syndrome: A child with multiple anomalies, smooth muscle hamartoma, and familial paracentric inversion of chromosome 7q. J Am Acad Dermatol 1993;28:364 # Schnur RE, Zackai EH: Circumferential ringed creases ("Michelin tire babies") with specific histologic findings and/or karyotype abnormalities: Clues to molecular pathogenesis? (Letter) Am J Med Genet 1997;69:221 # Pivnick EK, Wilroy RS, Martens PR, et al: Hypertrichosis, pigmentary retinopathy, and facial anomalies: A new syndrome? Am J Med Genet 1996;62:386 # Oku T, Iwasaki K, Fujita H: Folded skin with an underlying cutaneous smooth muscle hamartoma. Brit J Dermatol 1993;129:606 ==External links== * {{OMIM|156610}} * [http://www.contemporarypediatrics.com/contpeds/article/articleDetail.jsp?id=111755 Contemporary Pediatrics] * [http://dermatlas.med.jhmi.edu/derm/result.cfm?Diagnosis=-1458134276 DermAtlas images] {{medical-stub}} [[Category:Pediatrics]] [[pl:Zespół dziecka-opony Michelin]]