Mitochondrial myopathy 2858614 210464648 2008-05-06T01:03:03Z Rjwilmsi 203434 accessdate compliance to [[Template:Cite_web#Required_parameters|Template:Cite_web]], Replaced: accessdate = 8 February 2008 → accessdate = 2008-02-08 using [[Project:AutoWikiBrowser|AWB]] {{Refimprove|date=February 2008}} {{Infobox_Disease | Name = {{PAGENAME}} | Image = Diagram of an animal mitochondrion.svg | Caption = Simplified structure of a typical mitochondrion | DiseasesDB = | ICD10 = {{ICD10|G|71|3|g|70}} | ICD9 = | ICDO = | OMIM = | MedlinePlus = | eMedicineSubj = | eMedicineTopic = | MeshID = D017240 | }} '''Mitochondrial myopathy''' are a type of [[myopathy]] associated with [[mitochondrial disease]]. ==Treatment== Although no cure currently exists, there is some hope for a treatment for this whole class of [[hereditary disease]]s with the use of an [[embryotic]] mitochindrial transplant. <ref Name="BBC_5_February_2008">{{cite web | title =Three-parent embryo formed in lab | work =Scientists believe they have made a potential breakthrough in the treatment of serious disease by creating a human embryo with three separate parents. | publisher = BBC News | date = Tuesday, 5 February 2008, 11:13 GMT | url =http://news.bbc.co.uk/2/hi/health/7227861.stm | format =web | doi = | accessdate = 2008-02-08 }}</ref> ==Examples== Examples of Mitochondrial myopathy include: * [[Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like syndrome]] (MELAS) ** varying degrees of cognitive impairment and dementia ** [[lactic acidosis]] ** [[stroke]]s ** [[transient ischemic attack]]s ** hearing loss ** [[dysmotility]] ** weight loss * [[Myoclonic epilepsy and ragged-red fibers]] (MERRF) ** progressive myoclonic epilepsy ** clumps of diseased mitochondria accumulate in the subsarcolemmal region of the muscle fiber and appear as "ragged-red fibers" when muscle is stained with modified Gomori trichrome stain ** short stature * [[Kearns-Sayre syndrome]] (KSS) ** external [[ophthalmoplegia]] ** cardiac conduction defects ** sensory-neural hearing loss * [[Progressive external ophthalmoplegia]] (PEO) ** progressive [[ophthalmoparesis]] is the cardinal feature ** symptomatic overlap with many other mitochondrial myopathies ==References== {{reflist}} {{PNS diseases of the nervous system}} {{Mitochondrial diseases}} [[Category:Muscular disorders]] [[Category:Mitochondrial diseases]]