Molybdopterin
4789591
220311031
2008-06-19T06:46:27Z
Stone
13976
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|ImageFile=Molybdopterin.svg
|ImageSize=300px
|ImageFile2=Molybdopterin 3D.png
|ImageSize2=300px
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|Section1= {{Chembox Identifiers
| CASNo=73508-07-3
| PubChem=459
| SMILES=
| MeSHName=molybdopterin
}}
|Section2= {{Chembox Properties
| Formula=C<sub>10</sub>H<sub>14</sub>N<sub>5</sub>O<sub>6</sub>PS<sub>2</sub>
| MolarMass=395.354 g/mol
| Appearance=
| Density=
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}}
|Section3= {{Chembox Hazards
| MainHazards=
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| Autoignition=
}}
}}
'''Molybdopterins''' are a class of [[cofactor (biochemistry)|biochemical cofactors]] that are used in many different enzymes. The simplest structure of molybdopterin contains a [[pyranopterin]] coordinated to [[molybdenum]]. The [[pyranopterin]] structure is a fused ring system containing a [[pyran]] fused to [[pterin]]. In addition, the pyran ring is substituted with two [[thiol]]s and an alkyl [[phosphate]]. In molybdopterin, the thiols coordinate to molybdenum. In some cases, the alkyl phosphate group is replaced by an alkyl diphosphate [[nucleotide]].
There are several enzymes whose function depends on the molybdopterin cofactor. Some of these include [[xanthine oxidase]], [[DMSO reductase]], [[sulfite oxidase]], and [[nitrate reductase]].
Some effort has been placed into modeling the active sites of enzymes containing Molybdopterin using a class of ligands known as [[dithiolene|Dithiolenes]].
==References==
*{{cite journal
| author = Kisker, C.; Schindelin, H.; Baas, D.; Rétey, J.; Meckenstock, R.U.; Kroneck, P.M.H.
| title = A structural comparison of molybdenum cofactor-containing enzymes
| journal = FEMS Microbiol. Rev.
| year = 1999
| volume = 22
| pages = 503–521
| doi = 10.1111/j.1574-6976.1998.tb00384.x
}} {{PMID|9990727}}
{{Enzyme cofactors}}
[[Category:Molybdenum compounds]]
[[Category:Cofactors]]
[[Category:Organometallic compounds]]