Molybdopterin 4789591 220311031 2008-06-19T06:46:27Z Stone 13976 {{Chembox new |ImageFile=Molybdopterin.svg |ImageSize=300px |ImageFile2=Molybdopterin 3D.png |ImageSize2=300px |IUPACName= |OtherNames= |Section1= {{Chembox Identifiers | CASNo=73508-07-3 | PubChem=459 | SMILES= | MeSHName=molybdopterin }} |Section2= {{Chembox Properties | Formula=C<sub>10</sub>H<sub>14</sub>N<sub>5</sub>O<sub>6</sub>PS<sub>2</sub> | MolarMass=395.354 g/mol | Appearance= | Density= | MeltingPt= | BoilingPt= | Solubility= }} |Section3= {{Chembox Hazards | MainHazards= | FlashPt= | Autoignition= }} }} '''Molybdopterins''' are a class of [[cofactor (biochemistry)|biochemical cofactors]] that are used in many different enzymes. The simplest structure of molybdopterin contains a [[pyranopterin]] coordinated to [[molybdenum]]. The [[pyranopterin]] structure is a fused ring system containing a [[pyran]] fused to [[pterin]]. In addition, the pyran ring is substituted with two [[thiol]]s and an alkyl [[phosphate]]. In molybdopterin, the thiols coordinate to molybdenum. In some cases, the alkyl phosphate group is replaced by an alkyl diphosphate [[nucleotide]]. There are several enzymes whose function depends on the molybdopterin cofactor. Some of these include [[xanthine oxidase]], [[DMSO reductase]], [[sulfite oxidase]], and [[nitrate reductase]]. Some effort has been placed into modeling the active sites of enzymes containing Molybdopterin using a class of ligands known as [[dithiolene|Dithiolenes]]. ==References== *{{cite journal | author = Kisker, C.; Schindelin, H.; Baas, D.; Rétey, J.; Meckenstock, R.U.; Kroneck, P.M.H. | title = A structural comparison of molybdenum cofactor-containing enzymes | journal = FEMS Microbiol. Rev. | year = 1999 | volume = 22 | pages = 503–521 | doi = 10.1111/j.1574-6976.1998.tb00384.x }} {{PMID|9990727}} {{Enzyme cofactors}} [[Category:Molybdenum compounds]] [[Category:Cofactors]] [[Category:Organometallic compounds]]