Myopathy 1531683 217708935 2008-06-07T08:22:23Z PipepBot 4984067 robot Adding: [[it:Miopatia]] {{Infobox_Disease | Name = {{PAGENAME}} | Image = | Caption = | DiseasesDB = 8723 | ICD10 = {{ICD10|G|71||g|70}} - {{ICD10|G|72||g|70}} | ICD9 = {{ICD9|359.4}} - {{ICD9|359.9}} | ICDO = | OMIM = | MedlinePlus = | eMedicineSubj = emerg | eMedicineTopic = 328 | MeshID = D009135 | }} In [[medicine]], a '''myopathy''' is a neuromuscular [[disease]] in which the [[muscle fiber]]s do not function for any one of many reasons, resulting in [[muscular weakness]]. "Myopathy" simply means muscle disease (myo- [[Greek language|Greek]] μυσ "muscle" + [[pathy|-pathy]] [[Greek language|Greek]] "suffering"). This meaning implies that the primary defect is within the muscle, as opposed to the nerves ("[[neuropathies]]" or "[[neurogenic]]" disorders) or elsewhere (e.g., the brain etc.). [[Muscle cramp]]s, [[stiffness]], and [[spasm]] can also be associated with myopathy. ==Classes== Because myopathy is such a general term, there are several classes of myopathy.... ([[ICD|ICD-10]] codes are provided where available.) * (G71.0) [[muscular dystrophies|Dystrophies]] (or muscular dystrophies) are a subgroup of myopathies characterized by muscle degeneration and regeneration. Clinically, muscular dystrophies are typically progressive, because the muscles' ability to regenerate is eventually lost, leading to progressive weakness, often leading to use of a [[wheelchair]], and eventually death, usually related to [[respiratory weakness]]. **Examples include duchenne muscular dystrophy, an x-linked condition affecting the dystrophin gene (Xp 21). Duchenne muscular dystrophy is characterised by promixal muscle weakness, seen most commonly by difficulty walking, using gower's manouvre to stand, and hypertrophy of the calf muscles. It is typically found around the age of 4, and sufferers are wheelchair bound by the age of 10. It severely limits lifespan, as most patients die in their early twenties of respiratory complications. ** other congential muscular dystrophies include - Limb-girdle dystrophy, myotonic dystrophy, fascio-scapular-humeral dystrophy, and distal. * (G71.1) [[Myotonia]] ** [[Neuromyotonia]] * (G71.2) The [[congenital myopathy|congenital myopathies]] do not show evidence for either a progressive dystrophic process (i.e., muscle death) or inflammation, but instead characteristic microscopic changes are seen in association with reduced contractile ability of the muscles. Among others, different congenital myopathies include: ** (G71.2) [[nemaline myopathy]] (characterized by presence of "nemaline rods" in the muscle), ** (G71.2) [[multi/minicore myopathy]] (characterized by multiple small "cores" or areas of disruption in the muscle fibers), ** (G71.2) [[Centronuclear myopathy (including myotubular myopathy)|centronuclear myopathy]] (or [[Centronuclear myopathy (including myotubular myopathy)|myotubular myopathy]]) (in which the [[cell nucleus|nuclei]] are abnormally found in the center of the muscle fibers) is a rare muscle [[wasting]] disorder that occurs in three forms: *** The most severe form is [[congenital|present at birth]], which is inherited as an [[X-linked]] genetic trait, and can cause severe respiratory muscle weakness. This is the form of [[Centronuclear myopathy (including myotubular myopathy)|centronuclear myopathy]] currently referred to as [[Centronuclear myopathy (including myotubular myopathy)|myotubular myopathy]]. *** A less severe form of [[Centronuclear myopathy (including myotubular myopathy)|centronuclear myopathy]] that may present itself at birth or in early childhood progresses slowly and is inherited as an [[autosomal recessive]] genetic trait. *** The least severe of the three forms of [[Centronuclear myopathy (including myotubular myopathy)|centronuclear myopathy]] first appears during the second and third decades of life and is slowly progressive; it is inherited as an [[autosomal dominant]] genetic trait. * (G71.3) [[Mitochondrial myopathies]] are due to defects in [[mitochondria]], which provide a critical source of energy for muscle. * (G72.3) [[Familial periodic paralysis]] * (G72.4) [[inflammatory myopathy|Inflammatory myopathies]] are caused by problems with the immune system attacking components of the muscle, leading to signs of [[inflammation]] in the muscle. * (G73.6) [[Metabolic myopathy|Metabolic myopathies]] result from defects in biochemical metabolism that primarily affect muscle ** (G73.6/E74.0) [[Glycogen storage disease]]s may affect muscle ** (G73.6/E75) [[Lipid storage disorder]] * (M33.0-M33.1) **[[Dermatomyositis]]is the same as polymyositis, but also shows skin changes - a violaceous periorbital rash, facial erythema, blue or red patches on the knuckles, ragged nail folds and dilated nail capilliaries. (M33.2) **[[polymyositis]] which has tender, weak muscles, a mild normocytic anaemia, raised creatinine kinase and inflammatory markers and shows short polyphasic action potentials on EMG. it is treated by immunosupressants like corticosteroids or azathioprine. **[[inclusion body myositis]], and related myopathies * (M61) [[Myositis ossificans]] * (M62.89) [[Rhabdomyolysis]] and (R82.1) [[myoglobinuria]]s *Common muscle (R25.2) [[cramps]] and (M25.6) [[stiffness]], and (R29.0) [[tetany (medical sign)|tetany]] ==Treatments== Because different types of myopathies are caused by many different pathways, there is no single treatment for myopathy. Treatments range from treatment of the symptoms to very specific cause-targeting treatments. [[Drug therapy]], [[physical therapy]], bracing for support, [[surgery]], and even [[acupuncture]] are current treatments for a variety of myopathies. {{PNS diseases of the nervous system}} [[Category:Muscular disorders]] [[de:Myopathie]] [[es:Miopatía]] [[fr:Myopathie]] [[it:Miopatia]]