4-Methyl-aminorex 3768013 218349461 2008-06-10T06:49:51Z C6541 6629538 {{weasel}} {{Drugbox |IUPAC_name = 4-methyl-5-phenyl-2-amino-oxazoline | image = 4-methylaminorex-2D-skeletal.png | image2 = 4-Methyl-aminorex.gif | CAS_number = 3568-94-3 | CAS_supplemental = 29493-77-4 - (±)-cis isomers | ATC_prefix= | ATC_suffix= | ATC_supplemental= | PubChem= | smiles = C1=CC=CC(=C1)C2C(N=C(O2)N)C | DrugBank= | C=10 | H=12 | N=2 | O=1 | molecular_weight = 176.21 | bioavailability= 62% oral; 79% nasal; 91 - 93.5% smoked; 100% IV | metabolism = [[Hepatic]] | elimination_half-life= 10-19 hours | excretion = [[Renal]] | pregnancy_US = D | legal_US = Schedule I | legal_CA = Schedule III | routes_of_administration= [[Oral]], [[Vaporize]]d, [[Wiktionary:insufflation|Insufflated]], [[Intravenous infusion|Injected]] }} '''4-Methyl-aminorex''' is a [[stimulant]] [[drug]] of the 2-[[amino]]-5-[[aryl]]oxazoline class. Commonly called "Euphoria," "U4EA,", "U4Euh", "Intellex", "4MA", "4-MAR", "4-MAX", or "methylaminorex"; 4-Methylaminorex has also been termed "ice" due to the appearance of pure 4MA as large, white crystals, although the street name "ice" is more commonly used for pure [[crystal]]line [[methamphetamine]]. The [[US Government]], by [[statute]], defines "ice" as [[methamphetamine]] with a [[purity]] of 80% or greater. It is banned in many countries as a [[stimulant]]. 4-Methylaminorex has effects comparable to methamphetamine but with a much longer duration. Some contend it has fewer side effects.{{Fact|date=February 2007}} Users of 4-methylaminorex generally believe it to be a non-addictive stimulant. Some users say that its effects are somewhat similar to [[modafinil]] and [[pemoline]] (which are generally considered to have a low risk of dependence)<ref name="titleEvidence of lack of abuse or dependence following ...[Drug Alcohol Depend. 1986] - PubMed Result">{{cite web |url=http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=3743405&ordinalpos=7&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum |title=Evidence of lack of abuse or dependence following ...[Drug Alcohol Depend. 1986] - PubMed Result |accessdate= |format= |work=}}</ref><ref name="titleModafinil: preclinical, clinical, and post-marketi...[Ann Clin Psychiatry. 2004 Apr-Jun] - PubMed Result">{{cite web |url=http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=15328903&ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum |title=Modafinil: preclinical, clinical, and post-marketi...[Ann Clin Psychiatry. 2004 Apr-Jun] - PubMed Result |accessdate= |format= |work=}}</ref> although 4-methylaminorex is much stronger than those drugs. More detailed user comments can be found on [http://www.erowid.org/chemicals/4_methylaminorex/4_methylaminorex_info1.shtml Erowid]. Contrary to these claims, the results of animal experiments conducted with this drug suggest that it has an abuse liability similar to cocaine and amphetamine. One study found that, "[s]timulus properties of racemic cis, racemic trans, and all four individual optical isomers of 4-methylaminorex were examined in rats trained to discriminate 1 mg/kg of S(+)amphetamine sulfate from saline. The S(+)amphetamine stimulus generalized to all of the agents investigated". <ref name="titleStimulus properties of a new designer drug: 4-meth...[Pharmacol Biochem Behav. 1990] - PubMed Result">{{cite web |url=http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=1971111&dopt=AbstractPlus |title=Stimulus properties of a new designer drug: 4-meth...[Pharmacol Biochem Behav. 1990] - PubMed Result |accessdate= |format= |work=}}</ref> A second study in which rats trained to discriminate either 0.75 mg/kg S(+)-amphetamine or 1.5 mg/kg fenfluramine from saline generalized to aminorex as amphetamine stimulus but not to fenfluramine.<ref name="titleAminorex produces stimulus effects similar to amph...[Pharmacol Biochem Behav. 1992] - PubMed Result">{{cite web |url=http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=1356272&dopt=AbstractPlus |title=Aminorex produces stimulus effects similar to amph...[Pharmacol Biochem Behav. 1992] - PubMed Result |accessdate= |format= |work=}}</ref> Rats trained to discriminate 8 mg/kg cocaine from saline generalized 4-methylaminorex to cocaine-stimulus.<ref name="titleCocaine-stimulus generalization to two new designe...[Pharmacol Biochem Behav. 1993] - PubMed Result">{{cite web |url=http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=8516363&dopt=AbstractPlus |title=Cocaine-stimulus generalization to two new designe...[Pharmacol Biochem Behav. 1993] - PubMed Result |accessdate= |format= |work=}}</ref> The reinforcing effects of cis-4-methylaminorex were determined in two models of intravenous drug self-administration in primates. Vehicle or 4-methylaminorex doses were substituted for cocaine. One of the two different doses of 4-methylaminorex maintained self-administration behavior above vehicle control levels.<ref name="titleIntravenous self-administration of 4-methylaminore...[Drug Alcohol Depend. 1990] - PubMed Result">{{cite web |url=http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=2242714&dopt=AbstractPlus |title=Intravenous self-administration of 4-methylaminore...[Drug Alcohol Depend. 1990] - PubMed Result |accessdate= |format= |work=}}</ref> ==Chemistry== 4-methylaminorex exists as four [[stereoisomer]]s - (±)-''cis'' and (±)-''trans''. The (±)-''cis'' isomers are the form used [[Recreational drug|recreationally]]. The (±)-''cis'' isomers are generally synthesized from [[phenylpropanolamine|dl-phenylpropanolamine]] in one step by [[cyclization]] with [[cyanogen bromide]] (sometimes prepared ''[[In situ#Chemistry|in situ]]'' by reacting [[sodium cyanide]] with [[bromine]]). Alternate synthesis routes generally involve more steps, such as replacing cyanogen bromide with sodium or potassium [[cyanate]] to form an intermediate and then reacting it with concentrated [[hydrochloric acid]]. A method reported in microgram replaced the need for a sepeate addition of [[hydrochloric acid]] by starting with the hydrochloride salt of the [[phenylpropanolamine|dl-phenylpropanolamine]] but side-products are noted. The (±)-''trans'' isomers are synthesized in the same manner above but [[norpseudoephedrine|dl-norpseudoephedrine]] is used as the starting material instead. ==Dosage== 4-methylaminorex can be smoked, insufflated or taken orally. As an [[anorectic]], the [[Effective dose|ED50]] is 8.8 mg/kg in rats for the (±)-''cis'' isomers. The (±)-''trans'' isomers are slightly more potent at 7.0 mg/kg. As a [[recreational drug]], the effective dosage ranges from 5 to 25 mg.<ref name="titleErowid 4-methylaminorex Vault : Dosage">{{cite web |url=http://www.erowid.org/chemicals/4_methylaminorex/4_methylaminorex_dose.shtml |title=Erowid 4-methylaminorex Vault : Dosage |accessdate= |format= |work=}}</ref> In 1970s McNeil Laboratories, Inc was trying to bring 4-methylaminorex to drug market as a sympathomimetic (most commonly used as asthma-medicines), research name was McN-822, they mention that human dose would have been 0.25 mg/kg of body weight. They mention also LD50: 17mg/kg p.o for mice <ref name="titleSystem Timed Out (Library of Congress Online Catalog)">{{cite web |url=http://catalog.loc.gov/cgi-bin/Pwebrecon.cgi?v1=1&ti=1,1&Search%5FArg=Psychotropic%20drugs%20and%20related%20compounds&Search%5FCode=TALL&CNT=25&PID=22167&SEQ=20070902171132&SID=1 |title=System Timed Out (Library of Congress Online Catalog) |accessdate= |format= |work=}}</ref> There is a patent about the use of 4-methylaminorex "as a nasal decongestant which, when administered orally, does not produce adverse central nervous system stimulant effects as experienced with other decongestants and anorexiants." Dose mentioned is 0.25 mg/kg of body weight.<ref name="titleMethod of decongesting the nose ... - Google Patents">{{cite web |url=http://www.google.com/patents?id=XtgbAAAAEBAJ |title=Method of decongesting the nose ... - Google Patents |accessdate= |format= |work=}}</ref> ==Effects== It produces long-lasting effects, generally up to 16 hours in duration if taken orally and up to 12 hours if smoked or [[insufflated]]. Large doses have been reported anecdotally to last up to 36 hours. The effects are [[stimulant]] in nature, producing [[Euphoria (emotion)|euphoria]], an increase in attention, and increased [[cognition]]. Anecdotally, it has been reported to produce effects similar to [[nootropic]]s, however, there is no research to support the claim that it is any different or more effective than other psychostimulants in this respect. Moreover, 4-methylaminorex does not have the established safety profile of widely-used clinical psychostimulants such as [[methylphenidate]], [[dextroamphetamine]] and [[modafinil]]. There has been one reported death due to 4-methylaminorex and diazepam. Concentrations of 4-methylaminorex were: in blood 21.3 mg/L; in urine 12.3 mg/L. Diazepam concentration in blood was 0.8 mg/L.<ref name="titleA fatality involving U4Euh, a cyclic derivative of...[J Forensic Sci. 1988] - PubMed Result">{{cite web |url=http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=3373171&dopt=AbstractPlus |title=A fatality involving U4Euh, a cyclic derivative of...[J Forensic Sci. 1988] - PubMed Result |accessdate= |format= |work=}}</ref> One rat study<ref name="titleDetection and assay of cis- and trans-isomers of 4...[Forensic Sci Int. 2001] - PubMed Result">{{cite web |url=http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=11516888&dopt=AbstractPlus |title=Detection and assay of cis- and trans-isomers of 4...[Forensic Sci Int. 2001] - PubMed Result |accessdate= |format= |work=}}</ref> has studied excretion of 4-methylaminorex in urine: "The concentration of trans-4-methylaminorex in rat urine following four injections of the trans-4S,5S isomer (5 mg/kg i.p each, at intervals of 12 h in 2 days, as measured quantitatively by GC/MS" {| class="wikitable" |- ! Time (h) ! Concentration of 4-methylaminorex in urine (µg/ml) |- | 0-6 | 45 |- | 6-24 | 1.0 |- | 24-36 | 0.1 |- | 36-48 | not detected |} Also an another study has studied pharmacokinetics and tissue distribution of the stereoisomers of 4-methylaminorex in rats.<ref name="titlePharmacokinetics and tissue distribution of the st...[J Pharmacol Exp Ther. 2004] - PubMed Result">{{cite web |url=http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=14742748&dopt=AbstractPlus |title=Pharmacokinetics and tissue distribution of the st...[J Pharmacol Exp Ther. 2004] - PubMed Result |accessdate= |format= |work=}}</ref> "Pulmonary hypertension has been associated with ingestion of the appetite suppressant aminorex. A similar compound, 4-methylaminorex was discovered on the property of three individuals with diagnoses of pulmonary hypertension."<ref name="titleRecreational use of aminorex and pulmonary hyperte...[Chest. 2000] - PubMed Result">{{cite web |url=http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=11083709&dopt=AbstractPlus |title=Recreational use of aminorex and pulmonary hyperte...[Chest. 2000] - PubMed Result |accessdate= |format= |work=}}</ref> There have been three studies studying possible neurotoxicity of 4-methylaminorex. First study<ref name="titleNeurochemical effects of an acute treatment with 4...[Eur J Pharmacol. 1990] - PubMed Result">{{cite web |url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=1973111 |title=Neurochemical effects of an acute treatment with 4...[Eur J Pharmacol. 1990] - PubMed Result |accessdate= |format= |work=}}</ref> using quite high doses (highest dose caused clonic seizures and some rats died) in rats and studying short term effects (rats were killed 30 min to 18 h after injection of 5, 10 or 20 mg/kg of racemic cis-4-methylaminorex) suggested reduction in tryptophan hydroxylase (TPH) activity (a possible marker for serotonin neurotoxicity) but citing study: "No change in TPH activity was observed 30 min after injection; by 8 h the activity of this enzyme appeared to be recovering." and "this agent is significantly less neurotoxic than METH or MDMA." Study<ref name="titleResponse of monoaminergic and neuropeptide systems...[Eur J Pharmacol. 1992] - PubMed Result">{{cite web |url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=1358636 |title=Response of monoaminergic and neuropeptide systems...[Eur J Pharmacol. 1992] - PubMed Result |accessdate= |format= |work=}}</ref> published 2 years later than first one also suggested reduction in tryptophan hydroxylase activity, they used quite high dose too (10mg/kg of cis-4-methylaminorex) and studied also long term effects (rats were killed 3 h, 18 h or 7 days after injection), they found reduction of 20-40% of tryptophan hydroxylase (TPH) activity and "recovery of TPH activity occurred 18 h after treatment, but was significantly decreased again by 7 days." but "It is noteworthy that, unlike the other analogs, the striatal levels of 5-HT did not decline with TPH activity following multiple 4-methylaminorex treatment" Latest study<ref name="titleThe effects of aminorex and related compounds on b...[J Pharm Pharmacol. 1997] - PubMed Result">{{cite web |url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9120777 |title=The effects of aminorex and related compounds on b...[J Pharm Pharmacol. 1997] - PubMed Result |accessdate= |format= |work=}}</ref> (using mice) was not able to find any long term effects suggesting neurotoxicity and they found instead ''increase'' in serotonin levels, they used quite high doses too(15 mg/kg of each isomers studied) "The dosages used in the present experiments are about 6-10 times than the effective doses of aminorex and stereoisomers inhibition of food intake." Doses were repeated 3 times a day and mice were killed 7 days after last dose. "Since a long-lasting depletion of dopamine or 5-HT appears to be a good predictor of dopamine or 5-HT neurotoxicity (Wagner et al 1980; Ricaurte et al 1985), the results suggest that the aminorex compounds except 4S,SS-dimethylaminorex, unlike MDMA or fenfluramine, are not toxic to either dopamine or 5-HT neurotransmitter systems in CBA mice. It was reported that although multiple doses of 4-methylaminorex caused long-term (7 days) declines in striatal tryptophan hydroxylase activity in SD rats, no changes were found in 5-HT and 5-HIAA levels (Hanson et al 1992). <ref name="titleRecreational use of aminorex and pulmonary hyperte...[Chest. 2000] - PubMed Result">{{cite web |url=http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=11083709&dopt=AbstractPlus |title=Recreational use of aminorex and pulmonary hyperte...[Chest. 2000] - PubMed Result |accessdate= |format= |work=}}</ref> That first study [11] also suggested reduced dopamine (DA) levels (a possible marker for dopamine neurotoxicity), but citing study: "However, 8 h after drug administration no differences from control values were seen in DA, DOPAC or HVA levels." and again later studies [12-13] didn't find any long term reduction. ==Legal Status== In the [[Netherlands]], 4-Methylaminorex is a List I drug of the [[Opium Law]]. It is no approved by the CBG, and so it is designated as lacking any medical use. In the US, (±)-''cis''-4-methylaminorex was placed in Schedule I of the [[Controlled Substances Act]] shortly after its emergence as a recreational drug in the mid 1980s. Manufacturing the ''trans'' isomer required a different process that those encountered when the substance was first scheduled, and was believed less potent than the ''cis'' isomer with a much lower abuse potential.<sup>2</sup> However, studies revealing the abuse potential of the 'trans' isomer, coupled with the development of new clandestine synthetic methods that would produce the ''trans'' created a potential loophole in the law, which covered only the 'cis' isomer. To clarify the situation, the US [[Drug Enforcement Administration]] published a paper in its DEA Microgram Journal, regarding interpretation of the relevant statutory law as it relates to the status of ''trans''-4-methylaminorex. In summary, according to this non-legally binding decision, ''trans''-4-methylaminorex is not currently a controlled substance, but a potential analog. In fact, the report explicitly states: "''The United States [Drug Enforcment Administration] has the following opinion on the legality of the positional isomer "trans"-4-methylaminorex, which, unlike its 'cis' isomer was never placed in any schedule under the [[Controlled Substances Act]].''" However, the opinion does say that the agency considers the substance a potential [[controlled substance analog]], making the substance identical to a Schedule I substance if intended for human consumption, according to the [[analog act]] In fact, the report gives an account of a successful conviction under the [[analog act]] of an offense involving the 'trans' isomer. The full text, very detailed, sound legalistic interpretation, along with advances in clandestine chemistry that increases the production of the ''trans'' isomer can be read on the [[DEA Microgram]] 2005, Vol. 3 <ref name="Synthesis of trans-4-Methylaminorex from Norephedrine and Potassium Cyanate>{{cite web |url=www.dea.gov/programs/forensicsci/microgram/journal_v3_num34/journal_v3_num34_pg6.html |title=Synthesis of trans-4-Methylaminorex from Norephedrine and Potassium Cyanate |accessdate= |format= |work=}}</ref> ==See also== * [[Aminorex]] * [[Pemoline]] ==References== {{reflist}} ==External links== * [https://erowid.org/chemicals/4_methylaminorex/4_methylaminorex.shtml Erowid's 4-methylaminorex Vault] * [https://erowid.org/archive/rhodium/chemistry/u4euh.notes.txt Compiled Notes of U4Euh] * [http://www.dea.gov/programs/forensicsci/microgram/journal_v3_num34/journal_v3_num34_pg6.html Synthesis of trans-4-Methylaminorex from Norephedrine and Potassium Cyanate] {{stimulants}} {{DEFAULTSORT:Methyl-aminorex, 4-}} [[Category:Stimulants]] [[de:Euphoria (Droge)]] [[pl:4-Metylaminoreks]]