Olsalazine 5138402 215570225 2008-05-28T19:59:19Z ChemNerd 2246483 Quick-adding category "benzoic acids" (using [[WP:HOTCAT|HotCat]]) {{drugbox | | IUPAC_name = 5 - [(2Z) - 2 - (3 - carboxy - 4 - oxo - 1 - cyclohexa - 2,5 - dienylidene)hydrazinyl] - 2 - hydroxy - benzoic acid | image = Olsalazine.png | CAS_number = 15722-48-2 | ATC_prefix = A07 | ATC_suffix = EC03 | PubChem = 6003770 | DrugBank = | chemical_formula = | C=14 | H=10 | N=2 | O=6 | molecular_weight = 302.239g/mol | bioavailability = | protein_bound = 99% | metabolism = | elimination_half-life = 0.9 hours | excretion = | pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --> | pregnancy_US = C<!-- A / B / C / D / X --> | pregnancy_category= | legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 --> | legal_CA = <!-- / Schedule I, II, III, IV, V, VI, VII, VIII --> | legal_UK = <!-- GSL / P / POM / CD / Class A, B, C --> | legal_US = Rx-only<!-- OTC / Rx-only / Schedule I, II, III, IV, V --> | legal_status = | routes_of_administration = }} '''Olsalazine''' is an anti-inflammatory drug used in the treatment of [[Inflammatory Bowel Disease]] and [[Ulcerative Colitis]]. It is sold under the name Dipentum. The chemical name is 3,3' -azobis (6-hydroxybenzoate)salicylic acid. It is sold as the disodium salt. Like [[Balsalazide]], Olsalazine is believed to deliver [[Mesalazine]], or 5-aminosalicylic acid (5-ASA), past the small intestine, directly to the large intestine, which is that active site of disease in ulcerative colitis. ==History== Olsalazine gained [[Food and Drug Administration]] (FDA) approval in 1990. ==Supply== The drug is supplied by [[UCB (company)|UCB Pharma]]. ==Other indications== The Australian biotech company [[Giaconda]] has developed a combination therapy for treat constipation-predominant [[Irritable Bowel Syndrome]] that uses olsalazine and the anti-[[gout]] drug [[colchicine]]. ==External links== *[http://www.olsalazine.com/ Olsalazine official site] *[http://www.medicinenet.com/olsalazine/article.htm Medicine Net] {{Antidiarrheals, intestinal anti-inflammatory/anti-infective agents}} [[Category:Gastroenterology]] [[Category:benzoic acids]] {{drug-stub}}