Olsalazine
5138402
215570225
2008-05-28T19:59:19Z
ChemNerd
2246483
Quick-adding category "benzoic acids" (using [[WP:HOTCAT|HotCat]])
{{drugbox |
| IUPAC_name = 5 - [(2Z) - 2 - (3 - carboxy - 4 - oxo - 1 - cyclohexa - 2,5 - dienylidene)hydrazinyl] - 2 - hydroxy - benzoic acid
| image = Olsalazine.png
| CAS_number = 15722-48-2
| ATC_prefix = A07
| ATC_suffix = EC03
| PubChem = 6003770
| DrugBank =
| chemical_formula =
| C=14 | H=10 | N=2 | O=6
| molecular_weight = 302.239g/mol
| bioavailability =
| protein_bound = 99%
| metabolism =
| elimination_half-life = 0.9 hours
| excretion =
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
| pregnancy_US = C<!-- A / B / C / D / X -->
| pregnancy_category=
| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 -->
| legal_CA = <!-- / Schedule I, II, III, IV, V, VI, VII, VIII -->
| legal_UK = <!-- GSL / P / POM / CD / Class A, B, C -->
| legal_US = Rx-only<!-- OTC / Rx-only / Schedule I, II, III, IV, V -->
| legal_status =
| routes_of_administration =
}}
'''Olsalazine''' is an anti-inflammatory drug used in the treatment of [[Inflammatory Bowel Disease]] and [[Ulcerative Colitis]]. It is sold under the name Dipentum.
The chemical name is 3,3' -azobis (6-hydroxybenzoate)salicylic acid. It is sold as the disodium salt.
Like [[Balsalazide]], Olsalazine is believed to deliver [[Mesalazine]], or 5-aminosalicylic acid (5-ASA), past the small intestine, directly to the large intestine, which is that active site of disease in ulcerative colitis.
==History==
Olsalazine gained [[Food and Drug Administration]] (FDA) approval in 1990.
==Supply==
The drug is supplied by [[UCB (company)|UCB Pharma]].
==Other indications==
The Australian biotech company [[Giaconda]] has developed a combination therapy for treat constipation-predominant [[Irritable Bowel Syndrome]] that uses olsalazine and the anti-[[gout]] drug [[colchicine]].
==External links==
*[http://www.olsalazine.com/ Olsalazine official site]
*[http://www.medicinenet.com/olsalazine/article.htm Medicine Net]
{{Antidiarrheals, intestinal anti-inflammatory/anti-infective agents}}
[[Category:Gastroenterology]]
[[Category:benzoic acids]]
{{drug-stub}}