PROSITE
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2008-05-28T19:27:21Z
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'''PROSITE''' is a database of [[protein]] families and [[protein domains|domains]]. It consists of documentation entries describing protein domains, [[Protein family|families]] and functional sites as well as associated patterns and profiles to identify them. These are manually curated by a team of the [[Swiss Institute of Bioinformatics]] and tightly integrated into [[Swiss-Prot]] protein annotation. PROSITE was created in 1988 by [[Amos Bairoch]].
[[Image:Prosite.png|right]]
Its uses include identifying possible functions of newly-discovered proteins and analysis of known proteins for previously undetermined activity. PROSITE offers tools for sequence analysis and motif detection (see [[sequence motif]]). It is part of the [[ExPASy]] [[proteomics]] analysis servers.
The database '''ProRule''' builds on the domain descriptions of PROSITE. It provides additional information about functionally and/or structurally critical amino acids. The rules contain information about biologically meaningful residues, like active sites, binding sites, post-translational modification sites or disulfide bonds, to help function determination. These can automatically generate annotation based on PROSITE motifs.
==See also==
* [[Uniprot]] the universal protein database, a central resource on protein information - PROSITE adds data to it.
* [[InterPro]] a centralized database, grouping data from databases of protein families, domains and functional sites - part of the data come from PROSITE.
* [[Protein subcellular localization prediction]] another example of use of PROSITE.
==References==
* {{cite journal|title=[http://nar.oxfordjournals.org/cgi/screenpdf/gkm977v1 The 20 years of PROSITE.]| author=Hulo N., Bairoch A., Bulliard V., Cerutti L., Cuche B., De Castro E., Lachaize C., Langendijk-Genevaux P.S., Sigrist C.J.A. | journal=Nucleic Acids Res.|year=2007| pmid=18003654}}
* {{cite journal|title=[http://nar.oxfordjournals.org/cgi/screenpdf/34/suppl_2/W362 ScanProsite: detection of PROSITE signature matches and ProRule-associated functional and structural residues in proteins.] | author=De Castro E., Sigrist C.J.A., Gattiker A., Bulliard V., Langendijk-Genevaux P.S., Gasteiger E., Bairoch A., Hulo N. | journal=Nucleic Acids Res.|year=2006|volume=34(Web Server issue)|pages=W362–365 | pmid=16845026}}
* {{cite journal|title=[http://bioinformatics.oxfordjournals.org/cgi/reprint/21/21/4060 ProRule: a new database containing functional and structural information on PROSITE profiles.] | author=Sigrist CJ, De Castro E, Langendijk-Genevaux PS, Le Saux V, Bairoch A, Hulo N. | journal=Bioinformatics. |year=2005|volume=21(21)|pages=4060–4066 | pmid=16091411|doi=10.1093/bioinformatics/bti614}}
==External links==
*http://www.expasy.org/prosite/
*[http://www.expasy.org/prosite/prorule.html ProRule] - Database of rules based on PROSITE predictors
[[Category:Bioinformatics databases]]
[[Category:Bioinformatics]]
[[Category:Proteomics]]
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