Paget's disease of the breast 726615 223659803 2008-07-05T03:31:43Z Arcadian 104523 nav {{Infobox_Disease | Name = {{PAGENAME}} | Image = | Caption = | DiseasesDB = 9500 | ICD10 = {{ICD10|C|50||c|50}} | ICD9 = {{ICD9|174}} | ICDO = M8540/3 | OMIM = | MedlinePlus = | eMedicineSubj = derm | eMedicineTopic = 305 | MeshID = D010144 | }} '''Paget's disease of the [[breast]]''', also known as '''Paget's disease of the [[nipple]]''', is a condition that outwardly may have the appearance of [[eczema]] - with skin changes involving the nipple of the breast. Because of its seemingly innocuous and surface appearance, it often presents late, but it is a condition that may be fatal. [[Extramammary Paget's disease]] (EMPD) has the same histologic features as Paget's disease of the breast but different locations. ==Symptoms== The first symptom is usually an eczema-like rash, usually only affecting one nipple. The skin of the [[nipple]] and [[areola]] may be red and inflamed. Some women have an itching or burning sensation. Fluid (discharge) may leak from the abnormal area of cells. The nipple may turn inwards (be inverted). There may or may not be a lump in the breast, and there may be redness, oozing and crusting, and a sore that does not heal. ==Diagnosis== Recommended tests are a [[mammogram]] and a [[biopsy]] to confirm the diagnosis, and [[cytology]] may also be helpful. ==Treatment== Paget's disease of the breast is a type of cancer of the breast. Treatment usually involves some kind of [[mastectomy]] to surgically remove the tumour. [[Chemotherapy]] and/or [[radiotherapy]] may be necessary. ==History== The condition is named after Sir [[James Paget]], an English [[surgery|surgeon]] who first described it in [[1874]]. ==External links== *[http://www.cancer.gov/cancertopics/factsheet/Sites-Types/pagets-breast National Cancer Institute fact sheet] * [http://www.snopes.com/medical/disease/paget.asp Snopes] * [http://www.mayoclinic.com/health/pagets-disease-of-the-breast/DS00771 Overview at mayoclinic.com] * [http://etmd.medctr.ucla.edu/ETMD%2Fmd%20info%2Fphotos%2Fpaget.html Image at medctr.ucla.edu] {{Epithelial neoplasms}} {{Breast cancer/urogenital neoplasia}} [[Category:Dermatology]] [[Category:Types of cancer]] [[Category:Breast]] [[bs:Pagetov karcinom bradavice]] [[es:Enfermedad de Paget de seno]] [[it:Malattia di Paget del capezzolo]] [[nl:Ziekte van Paget (huid)]] [[pl:Rak Pageta]] [[sl:Pagetova bolezen dojke]] [[fi:Pagetin maitorauhastauti]]