Pancreatic lipase
1663427
220802876
2008-06-21T17:28:14Z
Fvasconcellos
1051513
/* Diagnostic Importance */ [[MoS:T]]
{{Protein
|Name={{PAGENAME}}
|image=Pancreatic lipase–colipase complex with inhibitor 1LPB.png
|caption=Cartoon diagram of human pancreatic lipase (colored by [[secondary structure]]: [[alpha helix|alpha helices]] in red, [[beta sheet]]s in yellow, and [[random coil]] in green) in complex with [[pig]] [[colipase]] (colored blue) and a [[small molecule]] [[enzyme inhibitor|inhibitor]] (upper left). From {{PDB|1LPB}}.
|Symbol=PNLIP
|AltSymbols=
|HGNCid=9155
|Chromosome=10
|Arm=q
|Band=26
|LocusSupplementaryData=.1
|ECnumber=3.1.1.3
|OMIM=246600
|EntrezGene=5406
|RefSeq=NM_000936
|UniProt=P16233
|PDB=
}}
'''Pancreatic lipase''' is an [[enzyme]] (more specifically, a [[lipase]]) secreted from the [[pancreas]] that uses [[hydrolysis]] to break apart [[fat]] [[molecules]]. [[Bile salts]] secreted from the [[liver]] and stored in [[gallbladder]] are released into the [[duodenum]] where they coat and emulsify large fat droplets into smaller droplets, thus increasing the overall [[surface area]] of the fat, which allows the lipase to break apart the fat more effectively. The resulting [[monomers]] are then moved by way of [[peristalsis]] along the [[small intestine]] to be absorbed into the [[lymphatic system]] by a specialized vessel called a [[lacteal]]. This protein belongs to [[pancreatic lipase family]].
Unlike some pancreatic enzymes like [[trypsin]] which are first secreted in the inactive form (e.g. [[trypsinogen]]), pancreatic lipase is secreted as the active enzyme.
== Diagnostic importance ==
Pancreatic lipase is secreted into the [[duodenum]] through the duct system of the pancreas. Normally its concentration of serum is very low. The basic pancreatic lipase used to digest the fat droplets is Streapsin, found in the intestinal lumen. Under extreme disruption of pancreatic function, such as [[pancreatitis]] or [[pancreatic cancer|pancreatic adenocarcinoma]], the pancreas may begin to [[autolysis|autolyse]] and release pancreatic enzymes into serum. Thus, through measurement of serum concentration of pancreatic lipase, pancreatitis can be diagnosed.
==See also==
* [[Orlistat]]
{{hydrolase-stub}}
{{Esterases}}
[[Category:Enzymes]]
[[Category:EC 3.1.1]]
[[pt:Lípase pancreática]]
[[ru:Панкреатическая липаза]]
[[ru:Панкреатическая липаза]]