Perkin reaction
1544082
221673724
2008-06-25T15:47:00Z
Chem-awb
4806773
[[Category:Name reactions]] using [[Project:AutoWikiBrowser|AWB]]
The '''Perkin reaction''' is an [[organic reaction]] developed by [[Sir William Henry Perkin|William Henry Perkin]] that can be used to make [[cinnamic acid]]s by the [[aldol condensation]] of [[aromatic]] [[aldehydes]] and [[acid anhydride]]s in the presence of an alkali salt of the acid.<ref>Perkin, W. H.; ''[[J. Chem. Soc.]]'' '''1868''', ''21'', 53, 181.</ref><ref>Perkin, W. H.; ''[[J. Chem. Soc.]]'' '''1877''', ''31'', 388.</ref>
[[Image:Perkin_Reaction_Scheme.png|center|650px|The Perkin reaction]]
Several reviews have been written.<ref>Johnson, J. R.; ''Org. React.'' '''1942''', ''1'', 210. (Review)</ref><ref>House, H. O. ''Modern Synthetic Reactions'' (W. A. Benjamin, Menlo Park, California, 2nd ed, 1972) pp 660-663.</ref><ref>Rosen, T.; ''Comp. Org. Syn.'' '''1991''', ''2'', 395-408. (Review)</ref>
The above mechanism is not universally accepted, as several versions exist, including decarboxylation without acetic group transfer {{Fact|date=November 2007}}.
==References==
{{reflist}}
==See also==
*[[Erlenmeyer-Plöchl azlactone and amino acid synthesis]]
*[[Stobbe condensation]]
[[Category:Condensation reactions]]
[[de:Perkin-Reaktion]]
[[ja:パーキン反応]]
[[it:Reazione di Perkin]]
[[ru:Реакция Перкина]]
[[pl:Kondensacja Perkina]]
[[Category:Name reactions]]