Perkin reaction 1544082 221673724 2008-06-25T15:47:00Z Chem-awb 4806773 [[Category:Name reactions]] using [[Project:AutoWikiBrowser|AWB]] The '''Perkin reaction''' is an [[organic reaction]] developed by [[Sir William Henry Perkin|William Henry Perkin]] that can be used to make [[cinnamic acid]]s by the [[aldol condensation]] of [[aromatic]] [[aldehydes]] and [[acid anhydride]]s in the presence of an alkali salt of the acid.<ref>Perkin, W. H.; ''[[J. Chem. Soc.]]'' '''1868''', ''21'', 53, 181.</ref><ref>Perkin, W. H.; ''[[J. Chem. Soc.]]'' '''1877''', ''31'', 388.</ref> [[Image:Perkin_Reaction_Scheme.png|center|650px|The Perkin reaction]] Several reviews have been written.<ref>Johnson, J. R.; ''Org. React.'' '''1942''', ''1'', 210. (Review)</ref><ref>House, H. O. ''Modern Synthetic Reactions'' (W. A. Benjamin, Menlo Park, California, 2nd ed, 1972) pp 660-663.</ref><ref>Rosen, T.; ''Comp. Org. Syn.'' '''1991''', ''2'', 395-408. (Review)</ref> The above mechanism is not universally accepted, as several versions exist, including decarboxylation without acetic group transfer {{Fact|date=November 2007}}. ==References== {{reflist}} ==See also== *[[Erlenmeyer-Plöchl azlactone and amino acid synthesis]] *[[Stobbe condensation]] [[Category:Condensation reactions]] [[de:Perkin-Reaktion]] [[ja:パーキン反応]] [[it:Reazione di Perkin]] [[ru:Реакция Перкина]] [[pl:Kondensacja Perkina]] [[Category:Name reactions]]