Peter C. Doherty 1157592 223512383 2008-07-04T11:37:07Z DOI bot 6652755 Citation maintenance. Formatted: doi. You can [[WP:DOI|use this bot]] yourself! Please [[User:DOI_bot/bugs|report any bugs]]. {{redirect|Peter Doherty}} {{Infobox Scientist |name = {{PAGENAME}} |box_width = |image =Replace_this_image_male.svg |image_size =150px |caption = {{PAGENAME}} |birth_date = [[15 October]] [[1940]] |birth_place = [[Brisbane]] |death_date = |death_place = |residence = |citizenship = |nationality = [[Australia]] |ethnicity = |field = [[medicine]]<br/>[[immunology]] |work_institutions = [[John Curtin School of Medical Research]] |alma_mater = [[University of Edinburgh]] |doctoral_advisor = |doctoral_students = |known_for = [[major histocompatibility complex]] |author_abbrev_bot = |author_abbrev_zoo = |influences = |influenced = |prizes = [[Image:Nobel prize medal.svg|20px]][[Nobel Prize in Physiology or Medicine]] in 1996 |religion = |footnotes = |signature = }} '''Peter Charles Doherty''', [[Order of Australia|AC]] (born [[15 October]] [[1940]]) is an [[Australia]]n [[Veterinary Surgeon]] and researcher in the field of [[medicine]]. He received the [[Albert Lasker Award for Basic Medical Research]] in 1995, the [[Nobel Prize in Physiology or Medicine]] in 1996, and was named [[Australian of the Year]] in 1997. Doherty's research focuses on the [[immune system]], and his Nobel work described how the body's immune cells protect against viruses. He and [[Rolf M. Zinkernagel]], the co-recipient of the 1996 Nobel Prize in Physiology or Medicine, discovered how [[T cell]]s recognize their target antigens in combination with [[major histocompatibility complex]] (MHC) proteins. Viruses infect host cells and reproduce inside them. Killer T-cells destroy those infected cells so that the viruses can't reproduce. Zinkernagel and Doherty discovered that, in order for killer T cells to recognize infected cells, they had to recognize two molecules on the surface of the cell &ndash; not only the virus antigen, but also a molecule of the [[major histocompatibility complex]] (MHC). This recognition was done by a T-cell receptor on the surface of the T cell. The MHC was previously identified as being responsible for the rejection of incompatible tissues during transplantation. Zinkernagel and Doherty discovered that the MHC was responsible for the body fighting meningitis viruses too.<ref>[http://nobelprize.org/nobel_prizes/medicine/laureates/1996/illpres/experiment.html The Nobel Prize in Physiology or Medicine 1996 &ndash; Illustrated Presentation]</ref> Doherty was born in [[Brisbane]], Queensland, where he attended [[Indooroopilly State High School]]. He received his bachelor's degree in veterinary science in 1962 and his master's degree in veterinary science in 1966 from the [[University of Queensland]]. After obtaining his PhD in 1970 from the [[University of Edinburgh]], [[Scotland]], he returned to Australia to perform his Nobel Prize-winning research at the [[John Curtin School of Medical Research]] in [[Canberra]]. Doherty currently spends three months of the year conducting research at [[St. Jude Children's Research Hospital]] in [[Memphis, Tennessee|Memphis]], [[Tennessee]], where he is a faculty member at the [[University of Tennessee Health Science Center]].[http://www.utmem.edu/pathology/our_faculty.htm] For the other 9 months of the year he resides at the [[University of Melbourne]], Victoria. His semi-autobiographical book, ''The Beginner's Guide to Winning the Nobel Prize'', was published by The Miegunyah Press, an imprint of Melbourne University Publishing Ltd, Melbourne in 2005. ==References== <references/> *{{cite journal | quotes = yes |last=Locke |first=Richard David |authorlink= |year=|month=. |title=Peter Charles Doherty |journal=[[Scalpel & tongs : American journal of medical philately]] |volume=47 |issue=1 |pages=2–3 | publisher = | location = | issn = | pmid = 12793421 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }} *{{cite journal | quotes = yes |last=Doherty |first=P C |authorlink= |year=[[1997]]|month=Dec. |title=The Nobel Lectures in Immunology. The Nobel Prize for Physiology or Medicine, 1996. Cell mediated immunity in virus infections |journal=[[Scand. J. Immunol.]] |volume=46 |issue=6 |pages=527–40 | publisher = | location = | issn = | pmid = 9420614 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }} *{{cite journal | quotes = yes |last=Zinkernagel |first=R M |authorlink= |year=[[1997]]|month=Nov. |title=The Nobel Lectures in Immunology. The Nobel Prize for Physiology or Medicine, 1996. Cellular immune recognition and the biological role of major transplantation antigens |journal=[[Scand. J. Immunol.]] |volume=46 |issue=5 |pages=421–36 | publisher = | location = | issn = | pmid = 9393624 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = | doi = 10.1046/j.1365-3083.1997.d01-149.x }} *{{cite journal | quotes = yes |last=Kuśnierczyk |first=P |authorlink= |year=[[1997]]|month=. |title=[Better late than never: discovery of MHC restriction awarded with the Nobel Prize after 22 years (Nobel Prize for physiology or medicine in 1996)] |journal=[[Postepy Biochem.]] |volume=43 |issue=2 |pages=66–72 | publisher = | location = | issn = | pmid = 9411434 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }} *{{cite journal | quotes = yes |last=Rennie |first=J |authorlink= |coauthors=Wallich P, Yam P |year=[[1997]]|month=Jan. |title=The 1996 Nobel prizes in science. Unveiling an antiviral defense |journal=[[Sci. Am.]] |volume=276 |issue=1 |pages=16, 18 | publisher = | location = | issn = | pmid = 8972615 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }} *{{cite journal | quotes = yes |last=ten Berge |first=R J |authorlink= |coauthors=Melief C J |year=[[1996]]|month=Dec. |title=[The Nobel Prize Medicine 1996 for the discovery of MHC restriction] |journal=[[Nederlands tijdschrift voor geneeskunde]] |volume=140 |issue=52 |pages=2607–10 | publisher = | location = | issn = | pmid = 9026737 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }} *{{cite journal | quotes = yes |last=Klareskog |first=L |authorlink= |coauthors=Kärre K, Möller E, Wigzell H |year=[[1996]]|month=Dec. |title=[Nobel Prize for discovery of the cell-mediated immune defence] |journal=[[Ugeskr. Laeg.]] |volume=158 |issue=51 |pages=7379–83 | publisher = | location = | issn = | pmid = 9012053 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }} *{{cite journal | quotes = yes |last=Thorsby |first=E |authorlink= |year=[[1996]]|month=Dec. |title=The Nobel Prize in medicine 1996 |journal=[[Scand. J. Immunol.]] |volume=44 |issue=6 |pages=541–3 | publisher = | location = | issn = | pmid = 8972732 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1046/j.1365-3083.1996.d01-361.x }} *{{cite journal | quotes = yes |last=Klareskog |first=L |authorlink= |coauthors=Kärre K, Möller E, Wigzell H |year=[[1996]]|month=Oct. |title=[The Nobel Prize for discovery of the cell-mediated immune defense. Significance for clinical medicine] |journal=[[Lakartidningen]] |volume=93 |issue=42 |pages=3714–7 | publisher = | location = | issn = | pmid = 8965536 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }} *{{cite journal | quotes = yes |last=Masood |first=E |authorlink= |coauthors=Weiss U |year=[[1996]]|month=Oct. |title=Nobel goes to T-cell pioneers whose work 'changed face of immunology' |journal=[[Nature (journal)|Nature]] |volume=383 |issue=6600 |pages=465 | publisher = | location = | issn = | pmid = 8849707 |doi = 10.1038/383465a0 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }} ==External links== *[http://www.stjude.org/faculty/0,2512,407_2030_3859,00.html Webpage at St. Jude] *[http://nobelprize.org/medicine/laureates/1996/doherty-autobio.html Nobel Biography] *[http://www.twis.org/audio/2006/09/05/ Radio Interview] from [[This Week in Science]] [[September 5]], [[2005]] broadcast *[http://www.cosmosmagazine.com/node/719 "Winning a Nobel: easy as wrestling a pig"], by Margaret Wertheim, ''Cosmos'' magazine, October 2006 {{start box}} {{Australian_of_the_Year_Award | before=Dr. [[John Yu]] | after=[[Cathy Freeman]]| year=1997}} {{end box}} {{Nobel Prize in Physiology or Medicine Laureates 1976-2000}} {{DEFAULTSORT:Doherty, Peter}} [[Category:1940 births|Doherty, Peter]] [[Category:Members of the National Academy of Sciences]] [[Category:Living people|Doherty, Peter]] [[Category:Nobel laureates in Physiology or Medicine|Doherty, Peter]] [[Category:Australian immunologists|Doherty, Peter]] [[Category:Veterinarians|Doherty, Peter]] [[Category:People from Brisbane|Doherty, Peter]] [[Category:Fellows of the Australian Academy of Science|Doherty]] [[Category:University of Queensland alumni]] {{Australia-scientist-stub}} [[ca:Peter Charles Doherty]] [[de:Peter Doherty]] [[es:Peter C. Doherty]] [[hr:Peter C. Doherty]] [[id:Peter Charles Doherty]] [[ja:ピーター・ドハーティー]] [[pl:Peter Doherty]] [[pt:Peter C. Doherty]] [[ru:Доэрти, Питер]] [[fi:Peter Doherty]] [[sv:Peter C. Doherty]]