Pharmacogenomics
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2008-07-07T10:18:52Z
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Reverted edits by [[Special:Contributions/203.87.207.226|203.87.207.226]] ([[User talk:203.87.207.226|talk]]) to last version by Thijs!bot
'''Pharmacogenomics''' is the branch of [[pharmacology]] which deals with the influence of [[genetics|genetic]] variation on drug response in patients by correlating [[gene expression]] or [[single-nucleotide polymorphism]]s with a drug's [[efficacy]] or [[toxicity]]. By doing so, pharmacogenomics aims to develop rational means to optimise drug therapy, with respect to the patients' [[genotype]], to ensure maximum efficacy with minimal [[adverse effect (medicine)|adverse effects]]. Such approaches promise the advent of "[[personalized medicine]]", in which drugs and drug combinations are optimised for each individual's unique genetic makeup.
Pharmacogenomics is the whole [[genome]] application of [[pharmacogenetics]], which examines the single gene interactions with drugs.
==See also==
* [[Genomics]]
** [[Chemogenomics]]
** [[Structural genomics]]
** [[Pharmacogenetics]]
** [[Toxicogenomics]]
** [[Clinomics]]
*[[Pharmaceutical company]]
==External links==
*[http://www.fda.gov/cder/genomics Genomics @ FDA] FDA's resource on genomics
*[http://astore.amazon.com/pharmacologyd-20/detail/1588298876/102-8665168-3357719 Pharmacogenomics in Drug Discovery and Development], a book on pharmacogenomics, diseases, and therapeutics
*[http://www.nature.com/omics/subjects/pharmacogenomics/index.html Nature '''pharmacogenomics''' gateway]
* [http://www.pharmgkb.org PharmGKB] The Pharmacogenetics and Pharmacogenomics Knowledge Base, an online free tool for Pharmacogenomics research
* [http://www.ncbi.nlm.nih.gov/About/primer/pharm.html NCBI Primer on Pharmacogenomics], a quick introduction to the promise of customised drugs.
* [http://gslc.genetics.utah.edu/units/pharma/ Pharmacogenomics: Drugs Designed for You], an accessible and comprehensive look at pharmacogenomics research, from the University of Utah's Genetic Science Learning Center
* [http://www.sciam.com/article.cfm?chanID=sa004&articleID=0006C064-7701-12ED-B70183414B7F0000 A Drug to Call One's Own : Will medicine finally get personal?] - Scientific American Magazine (August 2005)
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[[Category:Genomics]]
[[Category:Pharmacology]]
[[Category:Pharmacy]]
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