Phenyltoloxamine
2096931
224260849
2008-07-08T01:23:54Z
HellDragon
1758175
/* Common use */
{{Drugbox|
|IUPAC_name = 2-(2-benzylphenoxy)-''N'',''N''-dimethylethanamine
| image = Phenyltoloxamine.png
| width= 220
| CAS_number= 92-12-6
| ATC_prefix=
| ATC_suffix=
| ATC_supplemental=
| PubChem= 7077
| DrugBank=
| C=17 | H=21 | N=1 | O=1
| molecular_weight = 255.359
| bioavailability=
| metabolism =
| elimination_half-life=
| excretion =
| pregnancy_category =
| legal_US = OTC
| routes_of_administration= oral
}}
'''Phenyltoloxamine''' is an [[antihistamine]] with [[sedative]] and [[analgesic]] effects. It is a member of the [[ethanolamine]] class of [[antihistaminergic]] agents and a potent [[anticholinergic]], with 55 per cent of the anti-muscarinic potency of atropine.
==Common use==
Phenyltoloxamine is widely used in preparations as an enhancing [[agent]] for some analgesics and antitussives ([[acetaminophen]], [[codeine]], [[hydrocodone]]). It is widely used in certain parts of the world as [[cough suppressant]] usually with codeine.
It is also used to discourage [[abuse]] in certain [[opiate]] analgesics due its unpleasant side effects at high doses. While therapeutic doses of phenyltoloxamine can generate mild euphoria as can many of its chemical relatives, much higher doses have a side effect profile similar to that of [[atropine]], which is also used in this fashion for tablets of [[diphenoxylate]] and [[morphine]] for oral administration.
==Adverse effects==
Common [[adverse effects]] are those associated with most anticholinergics, effects are more pronounced in children and the elderly.
{{seealso|anticholinergic}}
==Availability==
Phenyltoloxamine is available in most countries, though it is rare in several [[western countries]] it remains widely used around the world, particularly in the [[developing world]].
It is not a [[controlled substance]]; however some preparations contain opiates such as codeine or hydrocodone and are controlled, when used in preparations with [[acetaminophen]] is generally [[over the counter]].
Phenyltoloxamine is sold under wide variety of preparations, brand names and dosages around the world:
*'''Ed-Flex''', '''Dologesic''', '''Flextra-650''', '''Novagesic''', '''Phenylgesic''' - North America
*'''Codipront''' - Europe/South America
{{Antihistamines}}
[[Category:Antihistamines]]