Phenyltoloxamine 2096931 224260849 2008-07-08T01:23:54Z HellDragon 1758175 /* Common use */ {{Drugbox| |IUPAC_name = 2-(2-benzylphenoxy)-''N'',''N''-dimethylethanamine | image = Phenyltoloxamine.png | width= 220 | CAS_number= 92-12-6 | ATC_prefix= | ATC_suffix= | ATC_supplemental= | PubChem= 7077 | DrugBank= | C=17 | H=21 | N=1 | O=1 | molecular_weight = 255.359 | bioavailability= | metabolism = | elimination_half-life= | excretion = | pregnancy_category = | legal_US = OTC | routes_of_administration= oral }} '''Phenyltoloxamine''' is an [[antihistamine]] with [[sedative]] and [[analgesic]] effects. It is a member of the [[ethanolamine]] class of [[antihistaminergic]] agents and a potent [[anticholinergic]], with 55 per cent of the anti-muscarinic potency of atropine. ==Common use== Phenyltoloxamine is widely used in preparations as an enhancing [[agent]] for some analgesics and antitussives ([[acetaminophen]], [[codeine]], [[hydrocodone]]). It is widely used in certain parts of the world as [[cough suppressant]] usually with codeine. It is also used to discourage [[abuse]] in certain [[opiate]] analgesics due its unpleasant side effects at high doses. While therapeutic doses of phenyltoloxamine can generate mild euphoria as can many of its chemical relatives, much higher doses have a side effect profile similar to that of [[atropine]], which is also used in this fashion for tablets of [[diphenoxylate]] and [[morphine]] for oral administration. ==Adverse effects== Common [[adverse effects]] are those associated with most anticholinergics, effects are more pronounced in children and the elderly. {{seealso|anticholinergic}} ==Availability== Phenyltoloxamine is available in most countries, though it is rare in several [[western countries]] it remains widely used around the world, particularly in the [[developing world]]. It is not a [[controlled substance]]; however some preparations contain opiates such as codeine or hydrocodone and are controlled, when used in preparations with [[acetaminophen]] is generally [[over the counter]]. Phenyltoloxamine is sold under wide variety of preparations, brand names and dosages around the world: *'''Ed-Flex''', '''Dologesic''', '''Flextra-650''', '''Novagesic''', '''Phenylgesic''' - North America *'''Codipront''' - Europe/South America {{Antihistamines}} [[Category:Antihistamines]]