Phosphorylase 1043015 224016819 2008-07-06T23:13:54Z SieBot 4005189 robot Adding: [[ms:Fosforilase]] {{Expert-verify|date=February 2007}} '''Phosphorylase''' is a family of [[Allosteric regulation|allosteric]] [[enzyme]]s that [[catalysis|catalyze]] the production of [[glucose-1-phosphate]] from a polyglucose such as [[glycogen]], [[starch]] or [[maltodextrin]]. ==Function== More generally, phosphorylases are enzymes that catalyze the addition of a phosphate group from an inorganic phosphate (phosphate+hydrogen) to an acceptor. Do not confuse this enzyme with a [[phosphatase]] or a [[kinase]]. A phosphatase removes a phosphate group from a donor, while a kinase transfers a phosphate group from a donor (usually ATP) to an acceptor. ==Types== The phosphorylases are named by prepending the name of the substrate, e.g. [[glycogen phosphorylase]], [[starch phosphorylase]], [[maltodextrin phosphorylase]]. All '''known''' phosphorylases share catalytic and structural properties [http://www.expasy.org/cgi-bin/nicedoc.pl?PDOC00095]. ==Activation== '''Phosphorylase a''' is the active form of glycogen phosphorylase that is derived from the phosphorylation of the inactive form, '''phosphorylase b'''. ==Pathology== Some disorders are related to phosphorylases: * [[Glycogen storage disease type V]] - muscle glycogen * [[Glycogen storage disease type VI]] - liver glycogen ==External links== * {{MeshName|Phosphorylases}} {{transferase-stub}} {{Glycosyltransferases}} [[Category:Transferases]] [[Category:EC 2.4.1]] [[ms:Fosforilase]]