Podosome
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210937442
2008-05-08T01:21:32Z
TimVickers
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add see also
'''Podosomes''' are the primary sites of [[integrin]] stimulated [[actin]] polymerization in [[leukocytes]] of the monocytic lineage. B cells have also been reported to form podosomes. Podosomes are similar in composition and structure to the [[invadopodia]] found in [[fibroblasts]] transformed with the [[v-Src]] [[oncogene]] which are matrix-degrading and whose formation is associated with increased [[tumor]] [[Cell (biology)|cell]] invasiveness.<ref>{{cite journal |author=Linder S |title=The matrix corroded: podosomes and invadopodia in extracellular matrix degradation |journal=Trends Cell Biol. |volume=17 |issue=3 |pages=107–17 |year=2007 |month=March |pmid=17275303 |doi=10.1016/j.tcb.2007.01.002}}</ref>
In [[myeloid]] cells, podosomes are necessary for directional movement and trans-cellular [[diapedesis]] at sites of inflammation.<ref>{{cite journal |author=Calle Y, Burns S, Thrasher AJ, Jones GE |title=The leukocyte podosome |journal=Eur. J. Cell Biol. |volume=85 |issue=3-4 |pages=151–7 |year=2006 |month=April |pmid=16546557 |doi=10.1016/j.ejcb.2005.09.003}} </ref> In [[osteoclasts]], podosomes are thought to aid in the creation of sealing rings associated with the area of [[bone resorption]].
Unlike focal contacts in fibroblasts and [[epithelial cells]], the formation of podosomes does not require protein synthesis.
==See also==
*[[Lamellipodia]]
==References==
{{reflist}}
==External links==
*[http://topics.scirus.com/Podosomes_and_Invadopodia.html Podosomes and Invadopodia] at Scirus Topic Pages
{{Structures of the cell membrane}}
{{Cell-biology-stub}}
[[Category:Cell anatomy]]
[[Category:Membrane biology]]