Primary progressive aphasia
2540923
220481865
2008-06-20T02:04:43Z
Dendritelady
2888661
/* References*/ updated
'''Primary progressive aphasia (PPA)''' is a gradually worsening disorder of speech with an insidious onset. It was first described by Marsel Mesulam in 1982.
There is considerable controversy over the [[nosology]] of this disorder. Clinical and pathological overlap have led it to being considered as part of the [[frontotemporal lobar degeneration]] (FTLD) spectrum of disorders. In the classical Mesulam criteria for PPA there are 2 variants: a non-fluent type ([[progressive non-fluent aphasia]] or PNFA) and a fluent aphasia. However, recent work has suggested that the underlying cognitive impairment in patients with progressive fluent aphasias is loss of semantic knowledge ([[semantic dementia]] or SD). [http://brain.oxfordjournals.org/cgi/content/full/129/11/3066] In the consensus criteria for FTLD described by Neary et al in 1989, PNFA and SD are the two classifications used.
The San Francisco group have recently suggested that there is a third variant of PPA (so-called logopaenic PPA - Gorno-Tempini et al, 2004). However, there are limited descriptions of this disorder in the medical literature and early reports suggest that it is an atypical form of Alzheimer's disease rather than a disease falling into the frontotemporal lobar degeneration spectrum.
There are no known risk factors for the progressive aphasias. However, one observational study has recently suggested that [[vasectomy]] could be a risk factor for PPA in men. These results have yet to be replicated elsewhere.
== References ==
* Amici S, Ogar J, Brambati SM, Miller BL, Neuhaus J, Dronkers NL, Gorno-Tempini ML. [http://www.ncbi.nlm.nih.gov/pubmed/18091068?ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Performance in specific language tasks correlates with regional volume changes in progressive aphasia]. ''Cognitive & Behavioral Neurology''. 2007;20:203-11.
* Gorno-Tempini ML, Dronkers NF, Rankin KP, Ogar JM, Phengrasamy L, Rosen HJ, Johnson JK, Weiner MW, Miller BL. [http://www.ncbi.nlm.nih.gov/pubmed/14991811?dopt=Abstract Cognition and anatomy in three variants of primary progressive aphasia]. ''Ann Neurol.'' 2004;55(3):335-46.
* Mesulam, MM. Primary progressive aphasia. ''Ann Neurol.'' 2001;49(4):425-32.
* Rosen HJ, Allison SC, Ogar JM, Amici S, Rose K, Dronkers N, Miller BL, Gorno-Tempini ML. [http://www.ncbi.nlm.nih.gov/pubmed/17130406?ordinalpos=12&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Behavioral features in semantic dementia vs other forms of progressive aphasias]. ''Neurology''. 2006;67:1752-6.
* Seeley WW, Matthews BR, Crawford RK, Gorno-Tempini ML, Foti D, Mackenzie IR, Miller BL. [http://www.ncbi.nlm.nih.gov/pubmed/18057074?ordinalpos=5&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Unravelling Boléro: progressive aphasia, transmodal creativity and the right posterior neocortex]. ''Brain''. 2008;131:39-49.
* Weintraub S, Fahey C, Johnson N, Mesulam MM, Gitelman DR, Weitner BB, Rademaker A. Vasectomy in men with primary progressive aphasia. ''Cogn Behav Neurol''. 2006;19(4):190-3. [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17159614&query_hl=3&itool=pubmed_docsum]
==External Links ==
* [http://memory.ucsf.edu/Education/Disease/ftd.html PPA information] from the [[UCSF]] Memory and Aging Center
[[Category:Aphasias]]
[[Category:Cognitive disorders]]
{{med-stub}}