Purinergic receptor
5665456
219488975
2008-06-15T13:51:19Z
Alaibot
1324179
Robot: sorting stub (based on existing categorisation)
'''Purinergic receptors''' are a family of newly characterized [[plasma membrane]] molecules involved in several and as yet only partially known cellular functions such as vascular reactivity, [[apoptosis]] and [[cytokine]] secretion.
Little is known about the effect extracellular microenvironment has on their function.
[[Fibroblasts]] share several features with [[smooth muscle]] cells and are an important constituent of the [[atherosclerotic]] plaque.
This receptors have their effect of high [[glucose]] concentration on [[Adenosine triphosphate|ATP]]-mediated responses in human fibroblasts.
The members of the family include the following:
{| class="wikitable"
| '''Name''' || '''Activation''' || '''Class'''
|-
| [[P1 receptors]] || [[adenosine]] || [[G protein-coupled receptor|G protein-coupled receptors]]
|-
| [[P2Y receptors]] || [[nucleotide]]s
*[[Adenosine triphosphate|ATP]]
*[[Adenosine diphosphate|ADP]]
*[[Uridine triphosphate|UTP]]
*[[Uridine diphosphate|UDP]]
*[[UDP-glucose]]
|| [[G protein-coupled receptor|G protein-coupled receptors]]
|-
| [[P2X receptors]] || [[adenosine triphosphate|ATP]] || [[ligand-gated ion channel]]
|}
==External links==
*[http://www.iuphar-db.org/GPCR/ChapterMenuForward?chapterID=1273 IUPHAR GPCR Database - Adenosine receptors]
*[http://www.iuphar-db.org/GPCR/ChapterMenuForward?chapterID=1294 IUPHAR GPCR Database - P2Y receptors]
* {{MeshName|Purinergic+Receptors}}
[[Category:G protein coupled receptors]]
[[zh:嘌呤受体]]
{{transmembranereceptor-stub}}
{{Transmembrane receptors}}
{{Ligand-gated ion channels}}
{{G protein-coupled receptors}}