Pyoderma gangrenosum
3114537
217808959
2008-06-07T19:52:15Z
Arcadian
104523
mesh
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{{Infobox_Disease |
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ICD10 = {{ICD10|L|88||l|80}} |
ICD9 = {{ICD9|686.01}} |
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MeshID = D017511 |
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'''Pyoderma gangrenosum''' is a disease that causes [[tissue (biology)|tissue]] to become [[necrosis|necrotic]], causing deep [[ulcer]]s that usually occur on the legs. When they occur, they can lead to [[chronic wound]]s. Ulcers usually initially look like small bug bites or [[papule]]s, and they progress to larger ulcers. Though the [[wound]]s rarely lead to death, they can cause [[pain]] and [[scar]]ring.
The disease was identified in 1930. It affects approximately 1 person in 100,000 in the population. Though it can affect people of any age, it mostly affects people in their 40s and 50s.<ref name="Jackson and Callen">Jackson JM and Callen JP. 2006. [http://www.emedicine.com/DERM/topic367.htm Emedicine: Pyoderma Gangrenosum.] Retrieved on [[January 23]], [[2007]].</ref>
==Types==
[[Image:Pyoderma gangrenosum 01.jpg|right|thumb|200px|Pyoderma gangrenosum]]
There are two main types of pyoderma gangrenosum:<ref name="Jackson and Callen"/>
* the normal ulcerative form, which occurs in the legs
* an 'atypical' form that is more superficial and occurs in the hands and other parts of the body
Other variations are<ref name="pmid16858047">{{cite journal |author=Brooklyn T, Dunnill G, Probert C |title=Diagnosis and treatment of pyoderma gangrenosum |journal=BMJ |volume=333 |issue=7560 |pages=181–4 |year=2006 |pmid=16858047 |doi=10.1136/bmj.333.7560.181}}</ref>:
* Peristomal pyoderma gangrenosum is 15% of all cases of pyoderma
* Bullous pyoderma gangrenosum
* Pustular pyoderma gangrenosum<ref name="pmid14616824">{{cite journal |author=Shankar S, Sterling JC, Rytina E |title=Pustular pyoderma gangrenosum |journal=Clin. Exp. Dermatol. |volume=28 |issue=6 |pages=600–3 |year=2003 |pmid=14616824 |doi=10.1046/j.1365-2230.2003.01418.x }}</ref>
* Vegetative pyoderma gangrenosum<ref name="pmid16101860">{{cite journal |author=Langan SM, Powell FC |title=Vegetative pyoderma gangrenosum: a report of two new cases and a review of the literature |journal=Int. J. Dermatol. |volume=44 |issue=8 |pages=623–9 |year=2005 |pmid=16101860 |doi=10.1111/j.1365-4632.2005.02591.x}}</ref>
==Causes==
Though the [[etiology]] is not well understood, the disease is thought to be due to [[immune system]] dysfunction, and particularly improper functioning of [[neutrophil]]s. At least half of all pyoderma gangrenosum patients also suffer from illnesses that affect their systemic function.<ref name="Jackson and Callen"/> For instance, [[ulcerative colitis]], [[Crohn's disease]], [[rheumatoid arthritis]], [[myeloma]] sufferers have the condition.
==Associations==
The common conditions associated with pyoderma gangrenosum are:
*Inflammatory bowel disease:
**Chronic ulcerative colitis
**Crohn's disease
*Arthritides:
**Rheumatoid arthritis
**Seronegative symmetrical polyarthritis
*Haematological disease:
**Myelocytic leukaemia
**Hairy cell leukaemia
**Myelofibrosis
**Myeloid metaplasia
**Monoclonal gammopathy (IgA)<ref>http://www.gpnotebook.com/simplepage.cfm?ID=-771358647&linkID=28508&cook=no</ref>
==Treatment==
A number of treatment options exist.<ref name="pmid16021123">{{cite journal |author=Reichrath J, Bens G, Bonowitz A, Tilgen W |title=Treatment recommendations for pyoderma gangrenosum: an evidence-based review of the literature based on more than 350 patients |journal=J. Am. Acad. Dermatol. |volume=53 |issue=2 |pages=273–83 |year=2005 |pmid=16021123 |doi=10.1016/j.jaad.2004.10.006}}</ref>
==References==
{{reflist}}
==External links==
* {{DermNet|reactions/pyoderma-gangrenosum}}
{{Diseases of the skin and subcutaneous tissue}}
[[Category:Skin diseases]]
[[Category:Rare diseases]]
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[[pl:Piodermia zgorzelinowa]]