Pyoderma gangrenosum 3114537 217808959 2008-06-07T19:52:15Z Arcadian 104523 mesh __NOTOC__ {{Infobox_Disease | Name = {{PAGENAME}} | Image = | Caption = | DiseasesDB = | ICD10 = {{ICD10|L|88||l|80}} | ICD9 = {{ICD9|686.01}} | ICDO = | OMIM = | MedlinePlus = | eMedicineSubj = | eMedicineTopic = | MeshID = D017511 | }} '''Pyoderma gangrenosum''' is a disease that causes [[tissue (biology)|tissue]] to become [[necrosis|necrotic]], causing deep [[ulcer]]s that usually occur on the legs. When they occur, they can lead to [[chronic wound]]s. Ulcers usually initially look like small bug bites or [[papule]]s, and they progress to larger ulcers. Though the [[wound]]s rarely lead to death, they can cause [[pain]] and [[scar]]ring. The disease was identified in 1930. It affects approximately 1 person in 100,000 in the population. Though it can affect people of any age, it mostly affects people in their 40s and 50s.<ref name="Jackson and Callen">Jackson JM and Callen JP. 2006. [http://www.emedicine.com/DERM/topic367.htm Emedicine: Pyoderma Gangrenosum.] Retrieved on [[January 23]], [[2007]].</ref> ==Types== [[Image:Pyoderma gangrenosum 01.jpg|right|thumb|200px|Pyoderma gangrenosum]] There are two main types of pyoderma gangrenosum:<ref name="Jackson and Callen"/> * the normal ulcerative form, which occurs in the legs * an 'atypical' form that is more superficial and occurs in the hands and other parts of the body Other variations are<ref name="pmid16858047">{{cite journal |author=Brooklyn T, Dunnill G, Probert C |title=Diagnosis and treatment of pyoderma gangrenosum |journal=BMJ |volume=333 |issue=7560 |pages=181–4 |year=2006 |pmid=16858047 |doi=10.1136/bmj.333.7560.181}}</ref>: * Peristomal pyoderma gangrenosum is 15% of all cases of pyoderma * Bullous pyoderma gangrenosum * Pustular pyoderma gangrenosum<ref name="pmid14616824">{{cite journal |author=Shankar S, Sterling JC, Rytina E |title=Pustular pyoderma gangrenosum |journal=Clin. Exp. Dermatol. |volume=28 |issue=6 |pages=600–3 |year=2003 |pmid=14616824 |doi=10.1046/j.1365-2230.2003.01418.x }}</ref> * Vegetative pyoderma gangrenosum<ref name="pmid16101860">{{cite journal |author=Langan SM, Powell FC |title=Vegetative pyoderma gangrenosum: a report of two new cases and a review of the literature |journal=Int. J. Dermatol. |volume=44 |issue=8 |pages=623–9 |year=2005 |pmid=16101860 |doi=10.1111/j.1365-4632.2005.02591.x}}</ref> ==Causes== Though the [[etiology]] is not well understood, the disease is thought to be due to [[immune system]] dysfunction, and particularly improper functioning of [[neutrophil]]s. At least half of all pyoderma gangrenosum patients also suffer from illnesses that affect their systemic function.<ref name="Jackson and Callen"/> For instance, [[ulcerative colitis]], [[Crohn's disease]], [[rheumatoid arthritis]], [[myeloma]] sufferers have the condition. ==Associations== The common conditions associated with pyoderma gangrenosum are: *Inflammatory bowel disease: **Chronic ulcerative colitis **Crohn's disease *Arthritides: **Rheumatoid arthritis **Seronegative symmetrical polyarthritis *Haematological disease: **Myelocytic leukaemia **Hairy cell leukaemia **Myelofibrosis **Myeloid metaplasia **Monoclonal gammopathy (IgA)<ref>http://www.gpnotebook.com/simplepage.cfm?ID=-771358647&linkID=28508&cook=no</ref> ==Treatment== A number of treatment options exist.<ref name="pmid16021123">{{cite journal |author=Reichrath J, Bens G, Bonowitz A, Tilgen W |title=Treatment recommendations for pyoderma gangrenosum: an evidence-based review of the literature based on more than 350 patients |journal=J. Am. Acad. Dermatol. |volume=53 |issue=2 |pages=273–83 |year=2005 |pmid=16021123 |doi=10.1016/j.jaad.2004.10.006}}</ref> ==References== {{reflist}} ==External links== * {{DermNet|reactions/pyoderma-gangrenosum}} {{Diseases of the skin and subcutaneous tissue}} [[Category:Skin diseases]] [[Category:Rare diseases]] {{dermatology-stub}} {{disease-stub}} [[de:Pyoderma gangraenosum]] [[nl:Pyoderma gangrenosum]] [[pl:Piodermia zgorzelinowa]]