Quaternium-15
1688737
193299625
2008-02-22T16:59:06Z
Rifleman 82
1255637
/* Safety concerns */ remove tag
{{Chembox new
| ImageFile = Quaternium-15.png
| ImageSize = 169
| IUPACName =
| OtherNames =
| Section1 = {{Chembox Identifiers
| CASNo = 4080-31-3
| PubChem = 5475987
| SMILES = Cl\C=C/C[N+]23CN1CN(C3)CN(C2)C1.[Cl-]
}}
| Section2 = {{Chembox Properties
| Formula = C<sub>9</sub>H<sub>16</sub>Cl<sub>2</sub>N<sub>4</sub>
| MolarMass = 251.156 g/mol
| Appearance =
| Density =
| MeltingPt =
| BoilingPt =
| Solubility =
}}
| Section3 = {{Chembox Hazards
| ExternalMSDS = [http://ptcl.chem.ox.ac.uk/MSDS/HE/hexamethylenetetramine_cis-chloroallyl_chloride.html External MSDS]
| EUClass = Harmful '''XN'''; Highly flammable '''F+'''
| MainHazards =
| FlashPt =
| Autoignition =
| RPhrases = {{R11}} {{R22}}
| SPhrases = {{S16}} {{S36}} }}
}}
'''Quaternium-15''' is a [[quaternary ammonium salt]] used as a [[preservative]] in many cosmetics and industrial substances. It acts as a [[formaldehyde releaser]]. It can cause [[contact dermatitis]], a symptom of an [[allergic reaction]], especially in those with [[sensitive skin]], on an infant's skin, or on sensitive areas such as the genitals.
It can be found under a variety of names, including: Dowicil 75; Dowicil 100; Dowco 184; Dowicide Q; 1-(3-Chloroallyl)-3,5,7-triaza-1-azoniaadamantane chloride; N-(3-chloroallyl) hexaminium chloride; hexamethylenetetramine chloroallyl chloride; 3,5,7-triaza-1-azoniaadamantane; 1-(3-chloroallyl)-chloride.
==Safety concerns==
Quaternium-15 is an [[allergen]], and can cause [[contact dermatitis]] in susceptible individuals.<ref name="CahillJ">Cahill J, Nixon R. Allergic contact dermatitis to quaternium 15 in a moisturizing lotion. ''Australas J Dermatol.'' 2005 Nov;46(4):284-5. PMID 16197434</ref> Many of those with an allergy to quaternium-15 are also allergic to formaldehyde. Allergic sensitivity to quaternium-15 can be detected using a [[patch test]].<ref>{{cite web|url=http://dermnetnz.org/dermatitis/quaternium-allergy.html|title=Quaternium-15 contact allergy|work=DermNet NZ|author=New Zealand Dermatological Society|accessdate=2007-05-31}}</ref>
It is the single most often found cause of allergic contact dermatitis of the hands (16.5% in 959 cases)<ref>E. Warshaw, '''''et al.''''' Contact dermatitis of the hands: Cross-sectional analyses of North American Contact Dermatitis Group Data, 1994-2004. Journal of the American Academy of Dermatology, Volume 57, Issue 2, Pages 301-314</ref>
==References==
<div class="references-small"><references/></div>
==External links==
*{{DermNet|dermatitis/quaternium-allergy}}
*[http://householdproducts.nlm.nih.gov/cgi-bin/household/brands?tbl=chem&id=138 National Institute of Health Household Products Database - Quaternium-15]
*[http://hazmap.nlm.nih.gov/cgi-bin/hazmap_generic?tbl=TblAgents&id=843 Occupational Hazards - Quaternium-15]
[[Category:Cosmetic chemicals]]
[[Category:Preservatives]]
[[Category:Quaternary ammonium compounds]]