Rebound effect
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219166661
2008-06-13T21:44:16Z
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{{otheruses4|the [[pharmacology|pharmacological]] term|for the [[energy conservation]] and [[marketing]] effect|Rebound effect (conservation)}}
'''Rebound effect''' is the tendency of a [[medication]] to, when discontinued, or when the recommended dose is exceeded, cause a return of the [[symptom]]s being treated in the first place. The symptoms might even be more severe than before. Medications with a known rebound effect can be withdrawn gradually or in conjunction with another medication which does not exhibit a rebound effect. In extreme cases, the symptom will be more pronounced after the medication is withdrawn than before it was used.
==Examples==
An example is the use of highly potent [[corticosteroid]]s, such as [[Clobetasol propionate|Clobetasol]] for [[psoriasis]]. Abrupt withdrawal can cause a much more severe case of the psoriasis to develop. Therefore, withdrawal should be gradual, diluting the medication with lotion perhaps, until very little actual medication is being applied.
Another example of [[pharmaceutical]] rebound is a [[rebound headache]].
Continuous usage of [[topical decongestant]]s (''[[nasal spray]]s'') can lead to constant [[nasal congestion]], known as [[Rhinitis medicamentosa]].
Several [[anxiolytic]]s have a rebound effect: For example, [[benzodiazepine withdrawal]] can cause severe [[anxiety]] and [[insomnia]]. Many [[antidepressant]]s, such as [[Selective serotonin reuptake inhibitor|SSRI]]s, can cause [[Clinical depression|depression]] when discontinued.
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