Robinson-Gabriel synthesis
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The '''Robinson-Gabriel synthesis''' is a [[chemical reaction]] that forms [[oxazole]]s by [[dehydration reaction|dehydration]] of 2-acylamino-[[ketone]]s.
[[Image:Robinson-Gabriel Synthesis Scheme.png|center|400px|The Robinson-Gabriel synthesis]]
Historically, the dehydration agent is concentrated [[sulfuric acid]]. Recently, [[phosphorus oxychloride]] is successful with this reaction also.
2-Acylamino-ketones can be synthesized using the [[Dakin-West reaction]].
==References==
*Robinson, R. ''J. Chem. Soc.'' '''1909''', ''95'', 2167.
*Gabriel, S. ''[[Ber.]]'' '''1910''', ''43'', 134.
*Gabriel, S. ''[[Ber.]]'' '''1910''', ''43'', 1283.
[[Category:Intramolecular condensation reactions]]
[[Category:Heterocycle forming reactions]]
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[[Category:Name reactions]]