Robinson-Gabriel synthesis 3041127 221674520 2008-06-25T15:51:06Z Chem-awb 4806773 [[Category:Name reactions]] using [[Project:AutoWikiBrowser|AWB]] The '''Robinson-Gabriel synthesis''' is a [[chemical reaction]] that forms [[oxazole]]s by [[dehydration reaction|dehydration]] of 2-acylamino-[[ketone]]s. [[Image:Robinson-Gabriel Synthesis Scheme.png|center|400px|The Robinson-Gabriel synthesis]] Historically, the dehydration agent is concentrated [[sulfuric acid]]. Recently, [[phosphorus oxychloride]] is successful with this reaction also. 2-Acylamino-ketones can be synthesized using the [[Dakin-West reaction]]. ==References== *Robinson, R. ''J. Chem. Soc.'' '''1909''', ''95'', 2167. *Gabriel, S. ''[[Ber.]]'' '''1910''', ''43'', 134. *Gabriel, S. ''[[Ber.]]'' '''1910''', ''43'', 1283. [[Category:Intramolecular condensation reactions]] [[Category:Heterocycle forming reactions]] {{reaction-stub}} [[Category:Name reactions]]